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Q03HT2 (DAPA_PEDPA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydrodipicolinate synthase
Short name=DHDPS
EC=4.2.1.52
Gene names
Name:dapA
Ordered Locus Names:PEPE_0133
OrganismPediococcus pentosaceus (strain ATCC 25745 / 183-1w) [Complete proteome] [HAMAP]
Taxonomic identifier278197 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Pediococcus

Protein attributes

Sequence length299 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O. HAMAP MF_00418

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4. HAMAP MF_00418

Subunit structure

Homotetramer By similarity. HAMAP MF_00418

Subcellular location

Cytoplasm By similarity HAMAP MF_00418.

Sequence similarities

Belongs to the DHDPS family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Diaminopimelate biosynthesis
Lysine biosynthesis
   Cellular componentCytoplasm
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdiaminopimelate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiondihydrodipicolinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 299299Dihydrodipicolinate synthase HAMAP MF_00418
PRO_0000340975

Regions

Region50 – 512Pyruvate binding By similarity

Sites

Active site1641Schiff-base intermediate with substrate By similarity
Binding site1091Pyruvate By similarity
Site1361Involved in proton transfer during cleavage By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03HT2 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 039CCC690C3FE4F3

FASTA29932,534
        10         20         30         40         50         60 
MLENVDLISA IITPFDDQLK INFTALERLT NHLIETGNTG FIIGGTTGET PTLTHAEKLG 

        70         80         90        100        110        120 
LYTRFAEIVA GRVPIIAGTG SNNTQATIDF TKEVRQIDGI IAALVVTPYY NKPNQRGMVA 

       130        140        150        160        170        180 
HFKTVARQAD FPIMMYNIPG RTGVQMENAT IVELSQEPNI IGIKQCTNLN DIGFLVENTP 

       190        200        210        220        230        240 
NDFAVYTGND PETLGAVALG ANGVASVASH IYGYQIRALL DAVKHGDLLK AGKLQRELTP 

       250        260        270        280        290 
KMEALFLYPS PAPVKAVLNA QNWSVGSPRL PILPLNQKEK LNLAHQLGVN HLADVQLHY

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000422 Genomic DNA. Translation: ABJ67240.1.
RefSeqYP_803682.1. NC_008525.1.

3D structure databases

ProteinModelPortalQ03HT2.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ03HT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4417131.
GenomeReviewsGene locus PEPE_0133 in contig CP000422_GR.
KEGGppe:PEPE_0133.
NMPDRfig|278197.10.peg.117.
PATRIC22873620. VBIPedPen34213_0127.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0329.
HOGENOMHBG358848.
OMARTDLAYY.
ProtClustDBPRK03170.

Enzyme and pathway databases

BioCycPPEN278197:PEPE_0133-MONOMER.

Family and domain databases

HAMAPMF_00418. DapA.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR002220. Dihydrodipicolinate_synth-like.
IPR020625. Dihydrodipicolinate_synth_AS.
IPR005263. Dihydrodipicolinate_synth_DapA.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KOK01714.
PANTHERPTHR12128. DHDPS. 1 hit.
PfamPF00701. DHDPS. 1 hit.
[Graphical view]
PIRSFPIRSF001365. DHDPS. 1 hit.
PRINTSPR00146. DHPICSNTHASE.
TIGRFAMsTIGR00674. DapA. 1 hit.
PROSITEPS00665. DHDPS_1. False negative.
PS00666. DHDPS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPA_PEDPA
AccessionPrimary (citable) accession number: Q03HT2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 14, 2006
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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