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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase

Gene

dapH

Organism
Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate.UniRule annotation

Catalytic activityi

Acetyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + L-2-acetamido-6-oxoheptanedioate.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase (dapH)
  2. no protein annotated in this organism
  3. N-acetyldiaminopimelate deacetylase (PEPE_0134)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesis, Lysine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00034; UER00022.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferaseUniRule annotation (EC:2.3.1.89UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-acetyltransferaseUniRule annotation
Short name:
THP acetyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate acetylaseUniRule annotation
Gene namesi
Name:dapHUniRule annotation
Ordered Locus Names:PEPE_0135
OrganismiPediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
Proteomesi
  • UP000000773 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003766841 – 2362,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferaseAdd BLAST236

Interactioni

Protein-protein interaction databases

STRINGi278197.PEPE_0135.

Structurei

3D structure databases

ProteinModelPortaliQ03HT0.
SMRiQ03HT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. DapH subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105DMJ. Bacteria.
COG2171. LUCA.
HOGENOMiHOG000040257.
KOiK00674.
OMAiNNAVIMM.
OrthoDBiPOG091H0G02.

Family and domain databases

Gene3Di3.30.70.250. 1 hit.
HAMAPiMF_01691. DapH. 1 hit.
InterProiView protein in InterPro
IPR019873. DapH.
IPR013710. DapH_N.
IPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR011004. Trimer_LpxA-like_sf.
PfamiView protein in Pfam
PF08503. DapH_N. 1 hit.
PF00132. Hexapep. 2 hits.
PF14602. Hexapep_2. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR03532. DapD_Ac. 1 hit.
PROSITEiView protein in PROSITE
PS00101. HEXAPEP_TRANSFERASES. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03HT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLDTQSII NTISNSKKQT PVRVFIAGEK LYQLQIPNEI EAFISPTSGT
60 70 80 90 100
LFGEWKYVKA LLESSSQITH YRVENDSRNS AVPLLDKKEV NARIEPGAII
110 120 130 140 150
RDQVLIGNNA VIMMGAIINI GAEIGAETMI DMGVVLGGRA LVGRHCHIGA
160 170 180 190 200
GAVLAGVIEP ASAQPVQIDD HVLIGANAVV VEGVHVGTGA VVAAGAVVTK
210 220 230
DVPAHTVVAG VPAQIIKRVD NTTSQKTALE DGLRNL
Length:236
Mass (Da):24,824
Last modified:November 14, 2006 - v1
Checksum:i3A3D6F73F0B64DE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000422 Genomic DNA. Translation: ABJ67242.1.
RefSeqiWP_011672866.1. NC_008525.1.

Genome annotation databases

EnsemblBacteriaiABJ67242; ABJ67242; PEPE_0135.
GeneIDi33062087.
KEGGippe:PEPE_0135.

Similar proteinsi

Entry informationi

Entry nameiDAPH_PEDPA
AccessioniPrimary (citable) accession number: Q03HT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: November 14, 2006
Last modified: November 22, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families