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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processDNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:PEPE_0469
OrganismiPediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
Proteomesi
  • UP000000773 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000099241 – 230Uracil-DNA glycosylaseAdd BLAST230

Interactioni

Protein-protein interaction databases

STRINGi278197.PEPE_0469.

Structurei

3D structure databases

ProteinModelPortaliQ03GV8.
SMRiQ03GV8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
KOiK03648.
OMAiQANGLCF.
OrthoDBiPOG091H03VL.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiView protein in InterPro
IPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
IPR036895. Uracil-DNA_glycosylase-like_sf.
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiView protein in Pfam
PF03167. UDG. 1 hit.
SMARTiView protein in SMART
SM00986. UDG. 1 hit.
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiView protein in PROSITE
PS00130. U_DNA_GLYCOSYLASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03GV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKIIHNDWQ DVLQGEFEQA YYAKLHEFLK HEYATQNIHP DMYHIFQAFE
60 70 80 90 100
WTPFSKVKVV ILGQDPYHGQ NQAHGLSFSV QPGVQVPPSL QNIYKELQSD
110 120 130 140 150
LGIAPVQHGY LKKWADQGVL LLNSVLTVRD GQAYSHQGHG WERLTDTAIQ
160 170 180 190 200
ALSEREQPVV FILWGKAARD KIKLIDQSRN IIIQSAHPSP LSAYRGFFGS
210 220 230
KPFSKTNEAL EAMGETPIDW QLPTEVLEEK
Length:230
Mass (Da):26,275
Last modified:November 14, 2006 - v1
Checksum:iB549AC50577DE5F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000422 Genomic DNA. Translation: ABJ67564.1.
RefSeqiWP_002834055.1. NC_008525.1.

Genome annotation databases

EnsemblBacteriaiABJ67564; ABJ67564; PEPE_0469.
GeneIDi33063060.
KEGGippe:PEPE_0469.

Similar proteinsi

Entry informationi

Entry nameiUNG_PEDPA
AccessioniPrimary (citable) accession number: Q03GV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 25, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families