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Q03GM6

- THIM_PEDPA

UniProt

Q03GM6 - THIM_PEDPA

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei41 – 411Substrate; via amide nitrogenUniRule annotation
    Binding sitei117 – 1171ATPUniRule annotation
    Binding sitei163 – 1631ATPUniRule annotation
    Binding sitei190 – 1901Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPEN278197:GI4Y-558-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:PEPE_0558
    OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
    Taxonomic identifieri278197 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
    ProteomesiUP000000773: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 265265Hydroxyethylthiazole kinasePRO_1000021524Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi278197.PEPE_0558.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03GM6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    OMAiTISESTY.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.
    TIGRFAMsiTIGR00694. thiM. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q03GM6-1 [UniParc]FASTAAdd to Basket

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    MNLQDIAKIR EVNPVVVNYA NFVTPFLVAN GLNAVGASPI MSDEVSEAEE    50
    LVQLASAVVI NAGASRKESW PLMNKLCEAA NQYQKPLVLD PVAVGATQYR 100
    KALNLMLLEK YHFDVIRGNI GEIAVLAGID WQTRGIDAGN GTGDMSAVVQ 150
    ACAQKFKNVV IASGEVDYIS DGQQVITVHN NTKLLPAIVG SGDLLSSIVG 200
    AFSAVAENTL DAAVTASLVL SCAGERAAAQ LDQQNRPGSF LSYLLDELAN 250
    ITPEQVQDLM KIGEA 265
    Length:265
    Mass (Da):28,099
    Last modified:November 14, 2006 - v1
    Checksum:i1D366A5C6998E1B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000422 Genomic DNA. Translation: ABJ67646.1.
    RefSeqiWP_011673144.1. NC_008525.1.
    YP_804088.1. NC_008525.1.

    Genome annotation databases

    EnsemblBacteriaiABJ67646; ABJ67646; PEPE_0558.
    GeneIDi4418248.
    KEGGippe:PEPE_0558.
    PATRICi22874474. VBIPedPen34213_0549.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000422 Genomic DNA. Translation: ABJ67646.1 .
    RefSeqi WP_011673144.1. NC_008525.1.
    YP_804088.1. NC_008525.1.

    3D structure databases

    ProteinModelPortali Q03GM6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 278197.PEPE_0558.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ67646 ; ABJ67646 ; PEPE_0558 .
    GeneIDi 4418248.
    KEGGi ppe:PEPE_0558.
    PATRICi 22874474. VBIPedPen34213_0549.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    OMAi TISESTY.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci PPEN278197:GI4Y-558-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    TIGRFAMsi TIGR00694. thiM. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25745 / 183-1w.

    Entry informationi

    Entry nameiTHIM_PEDPA
    AccessioniPrimary (citable) accession number: Q03GM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3