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Q03GG4

- SYL_PEDPA

UniProt

Q03GG4 - SYL_PEDPA

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Protein
Leucine--tRNA ligase
Gene
leuS, PEPE_0645
Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei580 – 5801ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPEN278197:GI4Y-645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:PEPE_0645
OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
ProteomesiUP000000773: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligaseUniRule annotation
PRO_1000009386Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi278197.PEPE_0645.

Structurei

3D structure databases

ProteinModelPortaliQ03GG4.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionUniRule annotation
Add
BLAST
Motifi577 – 5815"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03GG4-1 [UniParc]FASTAAdd to Basket

« Hide

MAYNHKDIEQ KWQQFWSDNE TFKTVEDADK PKYYALDMFP YPSGQGLHVG    50
HPEGYTATDI MSRMKRMQGY KVLHPMGWDA FGLPAEQYAM KTGNNPRDFT 100
AKNIQNFKRQ IQSLGFSYDW SREVNTTDPA YYKWTQWIFE QLYKKGLAYE 150
KETLVNWAPD LMGGTVVANE EVVDGKTERG GFPVYRKPMK QWILKITAYA 200
DRLIDDLDLV DWPDSIKEMQ KNWIGRSVGA SVFFNVEDSE KQIEVFTTRP 250
DTLFGATYLV ISPEHDLVDQ ITTPESKAAV EEYKKAVATK SDLERTDLNK 300
DKTGVFTGAY AVNPVNGKKI PVWISDYVLA SYGTGAVMAV PAHDGRDYEF 350
AKKFKIDMVP VYEGGNLEDG VLDSEGGLIN SGFLDGMDKQ TAIDTMISWL 400
EEHGVGHKKV NYRLRDWVFS RQRYWGEPIP VIHWEDGETT LIPEDELPLR 450
LPAATDIRPS GTGESPLANL DDWVNVVDEN GRKGRRETNT MPQWAGSSWY 500
FLRYVDPKND QKIADEDLLK EWLPVDLYVG GAEHAVLHLL YARFWHKVLY 550
DLGVVPTKEP FQKLVNQGMI LGSNHEKMSK SKGNVVNPDD IVERFGADTL 600
RLYEMFMGPL TESVAWSEDG LNGSRKWIDR VWRLMIDDEN QLRDHIVTEN 650
DGSLDMIYNQ TVKKVTDDYE NMRFNTAISQ MMVFVNEAYK ADKLPAVYME 700
GLVKMLAPII PHVAEELWSL LGHEGGISYA EWPTYDESKL VEATVQVILQ 750
VNGKVRSKIT VDKDIAKEEL EKLALADAKI QQWTADKTVR KVIVIPNKIV 800
NIVVG 805
Length:805
Mass (Da):91,896
Last modified:November 14, 2006 - v1
Checksum:iA74E606D0D908330
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ67708.1.
RefSeqiYP_804150.1. NC_008525.1.

Genome annotation databases

EnsemblBacteriaiABJ67708; ABJ67708; PEPE_0645.
GeneIDi4418531.
KEGGippe:PEPE_0645.
PATRICi22874648. VBIPedPen34213_0611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ67708.1 .
RefSeqi YP_804150.1. NC_008525.1.

3D structure databases

ProteinModelPortali Q03GG4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 278197.PEPE_0645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ67708 ; ABJ67708 ; PEPE_0645 .
GeneIDi 4418531.
KEGGi ppe:PEPE_0645.
PATRICi 22874648. VBIPedPen34213_0611.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PPEN278197:GI4Y-645-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25745 / 183-1w.

Entry informationi

Entry nameiSYL_PEDPA
AccessioniPrimary (citable) accession number: Q03GG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi