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Q03GG4

- SYL_PEDPA

UniProt

Q03GG4 - SYL_PEDPA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei580 – 5801ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPEN278197:GI4Y-645-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:PEPE_0645
    OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
    Taxonomic identifieri278197 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
    ProteomesiUP000000773: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 805805Leucine--tRNA ligasePRO_1000009386Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi278197.PEPE_0645.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03GG4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi577 – 5815"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiDKPKYYA.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03GG4-1 [UniParc]FASTAAdd to Basket

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    MAYNHKDIEQ KWQQFWSDNE TFKTVEDADK PKYYALDMFP YPSGQGLHVG    50
    HPEGYTATDI MSRMKRMQGY KVLHPMGWDA FGLPAEQYAM KTGNNPRDFT 100
    AKNIQNFKRQ IQSLGFSYDW SREVNTTDPA YYKWTQWIFE QLYKKGLAYE 150
    KETLVNWAPD LMGGTVVANE EVVDGKTERG GFPVYRKPMK QWILKITAYA 200
    DRLIDDLDLV DWPDSIKEMQ KNWIGRSVGA SVFFNVEDSE KQIEVFTTRP 250
    DTLFGATYLV ISPEHDLVDQ ITTPESKAAV EEYKKAVATK SDLERTDLNK 300
    DKTGVFTGAY AVNPVNGKKI PVWISDYVLA SYGTGAVMAV PAHDGRDYEF 350
    AKKFKIDMVP VYEGGNLEDG VLDSEGGLIN SGFLDGMDKQ TAIDTMISWL 400
    EEHGVGHKKV NYRLRDWVFS RQRYWGEPIP VIHWEDGETT LIPEDELPLR 450
    LPAATDIRPS GTGESPLANL DDWVNVVDEN GRKGRRETNT MPQWAGSSWY 500
    FLRYVDPKND QKIADEDLLK EWLPVDLYVG GAEHAVLHLL YARFWHKVLY 550
    DLGVVPTKEP FQKLVNQGMI LGSNHEKMSK SKGNVVNPDD IVERFGADTL 600
    RLYEMFMGPL TESVAWSEDG LNGSRKWIDR VWRLMIDDEN QLRDHIVTEN 650
    DGSLDMIYNQ TVKKVTDDYE NMRFNTAISQ MMVFVNEAYK ADKLPAVYME 700
    GLVKMLAPII PHVAEELWSL LGHEGGISYA EWPTYDESKL VEATVQVILQ 750
    VNGKVRSKIT VDKDIAKEEL EKLALADAKI QQWTADKTVR KVIVIPNKIV 800
    NIVVG 805
    Length:805
    Mass (Da):91,896
    Last modified:November 14, 2006 - v1
    Checksum:iA74E606D0D908330
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000422 Genomic DNA. Translation: ABJ67708.1.
    RefSeqiYP_804150.1. NC_008525.1.

    Genome annotation databases

    EnsemblBacteriaiABJ67708; ABJ67708; PEPE_0645.
    GeneIDi4418531.
    KEGGippe:PEPE_0645.
    PATRICi22874648. VBIPedPen34213_0611.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000422 Genomic DNA. Translation: ABJ67708.1 .
    RefSeqi YP_804150.1. NC_008525.1.

    3D structure databases

    ProteinModelPortali Q03GG4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 278197.PEPE_0645.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ67708 ; ABJ67708 ; PEPE_0645 .
    GeneIDi 4418531.
    KEGGi ppe:PEPE_0645.
    PATRICi 22874648. VBIPedPen34213_0611.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi DKPKYYA.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci PPEN278197:GI4Y-645-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25745 / 183-1w.

    Entry informationi

    Entry nameiSYL_PEDPA
    AccessioniPrimary (citable) accession number: Q03GG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3