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Q03GG4 (SYL_PEDPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:PEPE_0645
OrganismPediococcus pentosaceus (strain ATCC 25745 / 183-1w) [Complete proteome] [HAMAP]
Taxonomic identifier278197 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus

Protein attributes

Sequence length805 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processleucyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

aminoacyl-tRNA editing activity

Inferred from electronic annotation. Source: InterPro

leucine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 805805Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_1000009386

Regions

Motif40 – 5112"HIGH" region HAMAP-Rule MF_00049
Motif577 – 5815"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site5801ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03GG4 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: A74E606D0D908330

FASTA80591,896
        10         20         30         40         50         60 
MAYNHKDIEQ KWQQFWSDNE TFKTVEDADK PKYYALDMFP YPSGQGLHVG HPEGYTATDI 

        70         80         90        100        110        120 
MSRMKRMQGY KVLHPMGWDA FGLPAEQYAM KTGNNPRDFT AKNIQNFKRQ IQSLGFSYDW 

       130        140        150        160        170        180 
SREVNTTDPA YYKWTQWIFE QLYKKGLAYE KETLVNWAPD LMGGTVVANE EVVDGKTERG 

       190        200        210        220        230        240 
GFPVYRKPMK QWILKITAYA DRLIDDLDLV DWPDSIKEMQ KNWIGRSVGA SVFFNVEDSE 

       250        260        270        280        290        300 
KQIEVFTTRP DTLFGATYLV ISPEHDLVDQ ITTPESKAAV EEYKKAVATK SDLERTDLNK 

       310        320        330        340        350        360 
DKTGVFTGAY AVNPVNGKKI PVWISDYVLA SYGTGAVMAV PAHDGRDYEF AKKFKIDMVP 

       370        380        390        400        410        420 
VYEGGNLEDG VLDSEGGLIN SGFLDGMDKQ TAIDTMISWL EEHGVGHKKV NYRLRDWVFS 

       430        440        450        460        470        480 
RQRYWGEPIP VIHWEDGETT LIPEDELPLR LPAATDIRPS GTGESPLANL DDWVNVVDEN 

       490        500        510        520        530        540 
GRKGRRETNT MPQWAGSSWY FLRYVDPKND QKIADEDLLK EWLPVDLYVG GAEHAVLHLL 

       550        560        570        580        590        600 
YARFWHKVLY DLGVVPTKEP FQKLVNQGMI LGSNHEKMSK SKGNVVNPDD IVERFGADTL 

       610        620        630        640        650        660 
RLYEMFMGPL TESVAWSEDG LNGSRKWIDR VWRLMIDDEN QLRDHIVTEN DGSLDMIYNQ 

       670        680        690        700        710        720 
TVKKVTDDYE NMRFNTAISQ MMVFVNEAYK ADKLPAVYME GLVKMLAPII PHVAEELWSL 

       730        740        750        760        770        780 
LGHEGGISYA EWPTYDESKL VEATVQVILQ VNGKVRSKIT VDKDIAKEEL EKLALADAKI 

       790        800 
QQWTADKTVR KVIVIPNKIV NIVVG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000422 Genomic DNA. Translation: ABJ67708.1.
RefSeqYP_804150.1. NC_008525.1.

3D structure databases

ProteinModelPortalQ03GG4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING278197.PEPE_0645.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ67708; ABJ67708; PEPE_0645.
GeneID4418531.
KEGGppe:PEPE_0645.
PATRIC22874648. VBIPedPen34213_0611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0495.
HOGENOMHOG000200748.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Enzyme and pathway databases

BioCycPPEN278197:GI4Y-645-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_PEDPA
AccessionPrimary (citable) accession number: Q03GG4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries