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Q03GG4

- SYL_PEDPA

UniProt

Q03GG4 - SYL_PEDPA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei580 – 5801ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPEN278197:GI4Y-645-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:PEPE_0645
OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
ProteomesiUP000000773: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligasePRO_1000009386Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi278197.PEPE_0645.

Structurei

3D structure databases

ProteinModelPortaliQ03GG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi577 – 5815"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03GG4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYNHKDIEQ KWQQFWSDNE TFKTVEDADK PKYYALDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI MSRMKRMQGY KVLHPMGWDA FGLPAEQYAM KTGNNPRDFT
110 120 130 140 150
AKNIQNFKRQ IQSLGFSYDW SREVNTTDPA YYKWTQWIFE QLYKKGLAYE
160 170 180 190 200
KETLVNWAPD LMGGTVVANE EVVDGKTERG GFPVYRKPMK QWILKITAYA
210 220 230 240 250
DRLIDDLDLV DWPDSIKEMQ KNWIGRSVGA SVFFNVEDSE KQIEVFTTRP
260 270 280 290 300
DTLFGATYLV ISPEHDLVDQ ITTPESKAAV EEYKKAVATK SDLERTDLNK
310 320 330 340 350
DKTGVFTGAY AVNPVNGKKI PVWISDYVLA SYGTGAVMAV PAHDGRDYEF
360 370 380 390 400
AKKFKIDMVP VYEGGNLEDG VLDSEGGLIN SGFLDGMDKQ TAIDTMISWL
410 420 430 440 450
EEHGVGHKKV NYRLRDWVFS RQRYWGEPIP VIHWEDGETT LIPEDELPLR
460 470 480 490 500
LPAATDIRPS GTGESPLANL DDWVNVVDEN GRKGRRETNT MPQWAGSSWY
510 520 530 540 550
FLRYVDPKND QKIADEDLLK EWLPVDLYVG GAEHAVLHLL YARFWHKVLY
560 570 580 590 600
DLGVVPTKEP FQKLVNQGMI LGSNHEKMSK SKGNVVNPDD IVERFGADTL
610 620 630 640 650
RLYEMFMGPL TESVAWSEDG LNGSRKWIDR VWRLMIDDEN QLRDHIVTEN
660 670 680 690 700
DGSLDMIYNQ TVKKVTDDYE NMRFNTAISQ MMVFVNEAYK ADKLPAVYME
710 720 730 740 750
GLVKMLAPII PHVAEELWSL LGHEGGISYA EWPTYDESKL VEATVQVILQ
760 770 780 790 800
VNGKVRSKIT VDKDIAKEEL EKLALADAKI QQWTADKTVR KVIVIPNKIV

NIVVG
Length:805
Mass (Da):91,896
Last modified:November 14, 2006 - v1
Checksum:iA74E606D0D908330
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ67708.1.
RefSeqiYP_804150.1. NC_008525.1.

Genome annotation databases

EnsemblBacteriaiABJ67708; ABJ67708; PEPE_0645.
GeneIDi4418531.
KEGGippe:PEPE_0645.
PATRICi22874648. VBIPedPen34213_0611.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ67708.1 .
RefSeqi YP_804150.1. NC_008525.1.

3D structure databases

ProteinModelPortali Q03GG4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 278197.PEPE_0645.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ67708 ; ABJ67708 ; PEPE_0645 .
GeneIDi 4418531.
KEGGi ppe:PEPE_0645.
PATRICi 22874648. VBIPedPen34213_0611.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PPEN278197:GI4Y-645-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25745 / 183-1w.

Entry informationi

Entry nameiSYL_PEDPA
AccessioniPrimary (citable) accession number: Q03GG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3