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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPEN278197:GI4Y-939-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:PEPE_0939
OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
ProteomesiUP000000773 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_0000293051Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi278197.PEPE_0939.

Structurei

3D structure databases

ProteinModelPortaliQ03FM6.
SMRiQ03FM6. Positions 3-551.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03FM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDIEISQNA EMLPIQTIAK QAGFDEKVVE PYGHYKAKID IFSEKPNTQL
60 70 80 90 100
GKLVLVTSIN PTPAGEGKST VTVGLGDALN DLTGSAMIAL REPSQGPVMG
110 120 130 140 150
MKGGATGGGY SQVIPMDDIN LHFTGDMHAL TAANNTLAAL IDNHLQQGNE
160 170 180 190 200
LNIDPRTIVW RRCLDINDRA LRNIVIGLGG RFSGVPREDK FDITVASELM
210 220 230 240 250
AILCLAQDLK DLKERINRIL IANNYDGQPI FVKDLHVGGA IATLLKDAIK
260 270 280 290 300
PNLVQTLGHT PAIIHGGPFA NIAHGCNSVL ATKTALRHAK YTVTEAGFGA
310 320 330 340 350
DLGAEKFLDI KTPVLGKQPD AIVIVATVRA LKYNGGAKLA DLKIEDVEAL
360 370 380 390 400
QKGYINLQRH IKNMQRYNIP VTVSINHFIS DTDQEVNTLV KLIEAEGISA
410 420 430 440 450
IVTDAWAKGG AGSKDLANEV IALADTNQGP MTKLYDNNGR IEDKIKTIVQ
460 470 480 490 500
KIYGGSDVEY SPQALKKIKE CVANGWDHLP ICMAKSQYSF SDDPKQLGAP
510 520 530 540 550
SDFVMHVNDI NIRLGAGFLV VQTGKVLTMP GLPKHPAALD IDIDSKGEIT

GLF
Length:553
Mass (Da):59,599
Last modified:November 14, 2006 - v1
Checksum:i804DB52259F21793
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000422 Genomic DNA. Translation: ABJ67996.1.
RefSeqiWP_011673357.1. NC_008525.1.
YP_804438.1. NC_008525.1.

Genome annotation databases

EnsemblBacteriaiABJ67996; ABJ67996; PEPE_0939.
KEGGippe:PEPE_0939.
PATRICi22875214. VBIPedPen34213_0891.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000422 Genomic DNA. Translation: ABJ67996.1.
RefSeqiWP_011673357.1. NC_008525.1.
YP_804438.1. NC_008525.1.

3D structure databases

ProteinModelPortaliQ03FM6.
SMRiQ03FM6. Positions 3-551.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi278197.PEPE_0939.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ67996; ABJ67996; PEPE_0939.
KEGGippe:PEPE_0939.
PATRICi22875214. VBIPedPen34213_0891.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciPPEN278197:GI4Y-939-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25745 / 183-1w.

Entry informationi

Entry nameiFTHS_PEDPA
AccessioniPrimary (citable) accession number: Q03FM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: April 1, 2015
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.