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Q03FM6

- FTHS_PEDPA

UniProt

Q03FM6 - FTHS_PEDPA

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi62 – 698ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciPPEN278197:GI4Y-939-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:PEPE_0939
    OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
    Taxonomic identifieri278197 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
    ProteomesiUP000000773: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Formate--tetrahydrofolate ligasePRO_0000293051Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi278197.PEPE_0939.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03FM6.
    SMRiQ03FM6. Positions 3-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03FM6-1 [UniParc]FASTAAdd to Basket

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    MNDIEISQNA EMLPIQTIAK QAGFDEKVVE PYGHYKAKID IFSEKPNTQL    50
    GKLVLVTSIN PTPAGEGKST VTVGLGDALN DLTGSAMIAL REPSQGPVMG 100
    MKGGATGGGY SQVIPMDDIN LHFTGDMHAL TAANNTLAAL IDNHLQQGNE 150
    LNIDPRTIVW RRCLDINDRA LRNIVIGLGG RFSGVPREDK FDITVASELM 200
    AILCLAQDLK DLKERINRIL IANNYDGQPI FVKDLHVGGA IATLLKDAIK 250
    PNLVQTLGHT PAIIHGGPFA NIAHGCNSVL ATKTALRHAK YTVTEAGFGA 300
    DLGAEKFLDI KTPVLGKQPD AIVIVATVRA LKYNGGAKLA DLKIEDVEAL 350
    QKGYINLQRH IKNMQRYNIP VTVSINHFIS DTDQEVNTLV KLIEAEGISA 400
    IVTDAWAKGG AGSKDLANEV IALADTNQGP MTKLYDNNGR IEDKIKTIVQ 450
    KIYGGSDVEY SPQALKKIKE CVANGWDHLP ICMAKSQYSF SDDPKQLGAP 500
    SDFVMHVNDI NIRLGAGFLV VQTGKVLTMP GLPKHPAALD IDIDSKGEIT 550
    GLF 553
    Length:553
    Mass (Da):59,599
    Last modified:November 14, 2006 - v1
    Checksum:i804DB52259F21793
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000422 Genomic DNA. Translation: ABJ67996.1.
    RefSeqiYP_804438.1. NC_008525.1.

    Genome annotation databases

    EnsemblBacteriaiABJ67996; ABJ67996; PEPE_0939.
    GeneIDi4417751.
    KEGGippe:PEPE_0939.
    PATRICi22875214. VBIPedPen34213_0891.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000422 Genomic DNA. Translation: ABJ67996.1 .
    RefSeqi YP_804438.1. NC_008525.1.

    3D structure databases

    ProteinModelPortali Q03FM6.
    SMRi Q03FM6. Positions 3-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 278197.PEPE_0939.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ67996 ; ABJ67996 ; PEPE_0939 .
    GeneIDi 4417751.
    KEGGi ppe:PEPE_0939.
    PATRICi 22875214. VBIPedPen34213_0891.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci PPEN278197:GI4Y-939-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 25745 / 183-1w.

    Entry informationi

    Entry nameiFTHS_PEDPA
    AccessioniPrimary (citable) accession number: Q03FM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3