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Q03FM6 (FTHS_PEDPA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:PEPE_0939
OrganismPediococcus pentosaceus (strain ATCC 25745 / 183-1w) [Complete proteome] [HAMAP]
Taxonomic identifier278197 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293051

Regions

Nucleotide binding62 – 698ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03FM6 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 804DB52259F21793

FASTA55359,599
        10         20         30         40         50         60 
MNDIEISQNA EMLPIQTIAK QAGFDEKVVE PYGHYKAKID IFSEKPNTQL GKLVLVTSIN 

        70         80         90        100        110        120 
PTPAGEGKST VTVGLGDALN DLTGSAMIAL REPSQGPVMG MKGGATGGGY SQVIPMDDIN 

       130        140        150        160        170        180 
LHFTGDMHAL TAANNTLAAL IDNHLQQGNE LNIDPRTIVW RRCLDINDRA LRNIVIGLGG 

       190        200        210        220        230        240 
RFSGVPREDK FDITVASELM AILCLAQDLK DLKERINRIL IANNYDGQPI FVKDLHVGGA 

       250        260        270        280        290        300 
IATLLKDAIK PNLVQTLGHT PAIIHGGPFA NIAHGCNSVL ATKTALRHAK YTVTEAGFGA 

       310        320        330        340        350        360 
DLGAEKFLDI KTPVLGKQPD AIVIVATVRA LKYNGGAKLA DLKIEDVEAL QKGYINLQRH 

       370        380        390        400        410        420 
IKNMQRYNIP VTVSINHFIS DTDQEVNTLV KLIEAEGISA IVTDAWAKGG AGSKDLANEV 

       430        440        450        460        470        480 
IALADTNQGP MTKLYDNNGR IEDKIKTIVQ KIYGGSDVEY SPQALKKIKE CVANGWDHLP 

       490        500        510        520        530        540 
ICMAKSQYSF SDDPKQLGAP SDFVMHVNDI NIRLGAGFLV VQTGKVLTMP GLPKHPAALD 

       550 
IDIDSKGEIT GLF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000422 Genomic DNA. Translation: ABJ67996.1.
RefSeqYP_804438.1. NC_008525.1.

3D structure databases

ProteinModelPortalQ03FM6.
SMRQ03FM6. Positions 3-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING278197.PEPE_0939.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ67996; ABJ67996; PEPE_0939.
GeneID4417751.
KEGGppe:PEPE_0939.
PATRIC22875214. VBIPedPen34213_0891.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMACGEIMTM.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycPPEN278197:GI4Y-939-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_PEDPA
AccessionPrimary (citable) accession number: Q03FM6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways