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Protein

NAD kinase

Gene

nadK

Organism
Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei147NADUniRule annotation1
Binding sitei149NADUniRule annotation1
Binding sitei184NAD; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi121 – 122NADUniRule annotation2
Nucleotide bindingi160 – 165NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciPPEN278197:G1G70-1177-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:PEPE_1202
OrganismiPediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
Proteomesi
  • UP000000773 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000598821 – 269NAD kinaseAdd BLAST269

Proteomic databases

PRIDEiQ03EW6

Interactioni

Protein-protein interaction databases

STRINGi278197.PEPE_1202

Structurei

3D structure databases

ProteinModelPortaliQ03EW6
SMRiQ03EW6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q03EW6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVAIYHSSD EHSIQVGKDL AKILSQNEIV IDNEKPTVVI TIGGDGTLLS
60 70 80 90 100
AVQKYLNLLE EVRFVGVHTG HLGFYTDWRE YELETLVKAL KSDGGAEVSY
110 120 130 140 150
PLLNIDVTHT DGSHISYKAV NESTLRKLSG TMVADVLIGD NLFERFRGDG
160 170 180 190 200
LCISTPTGST AYNRSVGGAI VHPRLEVLQM AEIASINNRV FRTVGASLIM
210 220 230 240 250
APNETITIRP VPSFHRTYNF TADRIDLLDK HVKEVHYSID EQKVKFLKYR
260
HTGFWNRVRN SFIGSIDEV
Length:269
Mass (Da):30,104
Last modified:November 14, 2006 - v1
Checksum:i9C698C09836B1A15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000422 Genomic DNA Translation: ABJ68256.1
RefSeqiWP_011673552.1, NC_008525.1

Genome annotation databases

EnsemblBacteriaiABJ68256; ABJ68256; PEPE_1202
GeneIDi33062064
KEGGippe:PEPE_1202

Similar proteinsi

Entry informationi

Entry nameiNADK_PEDPA
AccessioniPrimary (citable) accession number: Q03EW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health