ID Q03EG2_PEDPA Unreviewed; 757 AA. AC Q03EG2; DT 14-NOV-2006, integrated into UniProtKB/TrEMBL. DT 14-NOV-2006, sequence version 1. DT 27-MAR-2024, entry version 101. DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053}; DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053}; GN OrderedLocusNames=PEPE_1372 {ECO:0000313|EMBL:ABJ68410.1}; OS Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / OS 183-1w). OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae; OC Pediococcus. OX NCBI_TaxID=278197 {ECO:0000313|EMBL:ABJ68410.1, ECO:0000313|Proteomes:UP000000773}; RN [1] {ECO:0000313|EMBL:ABJ68410.1, ECO:0000313|Proteomes:UP000000773} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w RC {ECO:0000313|Proteomes:UP000000773}; RX PubMed=17030793; DOI=10.1073/pnas.0607117103; RA Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E., RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., RA Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R., RA O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P., RA Kozyavkin S., Weimer B., Mills D.; RT "Comparative genomics of the lactic acid bacteria."; RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4; CC Evidence={ECO:0000256|ARBA:ARBA00034618, CC ECO:0000256|RuleBase:RU364053}; CC -!- CATALYTIC ACTIVITY: CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by CC translocating in the 3'-5' direction.; EC=5.6.2.4; CC Evidence={ECO:0000256|ARBA:ARBA00034617}; CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily. CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP000422; ABJ68410.1; -; Genomic_DNA. DR RefSeq; WP_011673639.1; NC_008525.1. DR AlphaFoldDB; Q03EG2; -. DR STRING; 278197.PEPE_1372; -. DR GeneID; 33061310; -. DR KEGG; ppe:PEPE_1372; -. DR eggNOG; COG0210; Bacteria. DR HOGENOM; CLU_004585_5_2_9; -. DR OrthoDB; 9810135at2; -. DR Proteomes; UP000000773; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro. DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW. DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro. DR CDD; cd17932; DEXQc_UvrD; 1. DR CDD; cd18807; SF1_C_UvrD; 1. DR Gene3D; 1.10.10.160; -; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA. DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf. DR InterPro; IPR014017; DNA_helicase_UvrD-like_C. DR InterPro; IPR000212; DNA_helicase_UvrD/REP. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR014016; UvrD-like_ATP-bd. DR NCBIfam; TIGR01073; pcrA; 1. DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1. DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1. DR Pfam; PF21196; PcrA_UvrD_tudor; 1. DR Pfam; PF00580; UvrD-helicase; 1. DR Pfam; PF13361; UvrD_C; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1. DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053}; KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE- KW ProRule:PRU00560}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE- KW ProRule:PRU00560}; Isomerase {ECO:0000256|ARBA:ARBA00023235}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00560}. FT DOMAIN 8..287 FT /note="UvrD-like helicase ATP-binding" FT /evidence="ECO:0000259|PROSITE:PS51198" FT DOMAIN 288..575 FT /note="UvrD-like helicase C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51217" FT BINDING 29..36 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560" SQ SEQUENCE 757 AA; 85870 MW; 43F716CEE180B3B4 CRC64; MPEINLIKGL NDMQKEAVQT TEGPLLIMAG AGSGKTRVLT HRVAYLIEEK GVNPWNVLAI TFTNKAAREM RERVTSLLGD EAAEIWVSTF HALCVRILRR NIDQLGYNRA FSIADPSEQR TLVKHILADL NYDPKKFDPR SVLGTISNAK NDLKTPLTYR ENASTPYEQV VADIYEEYQR RLENNQALDF DDLIMKTIEL FQKNPETLSF YQNKFHYIHV DEYQDTNQAQ YQLVTMLAKH FRNICVVGDS DQSIYGWRGA DMQNIMNFES DYPDSKTVML EQNYRSTQNI LNAANDVIEN NVERKPKQLW TDNDEGEKIS YYRGQTGIDE AHFIVQKIRE QIKEHNLNYG DFAILYRTNA QSRVIEDTFV KSNIPYLMVG GHKFYDRKEI RDVLSYLTLI ANEDDSMSFE RVINEPKRGI GSTSIAKLQA FADENNWSLL KAARSVQIAN GISSRARNAI EDFAKMIDAL RKSGEFLNIT ELTEAVLEQT GYRAALEKSR TMESEARLEN IDEFLTVTKQ FDDKNEAEGN EIADENGDNI QLVDFLADLA LVSDQDNVEE EPSGVTLMTL HAAKGLEFPI VFLVGMEDGI FPLSRAMMDQ EQLEEERRLA YVGITRARQK LYITNAYSRM LYGRTQTNPA SRFISEIGSQ YLKSENEEKS FSRNTKEKSY PFDNNRNARA TASVYGNTHA TAVKSNGSGA GKVSWNAGDK VEHKAWGIGT VVKVSGAGED AELDIAFKDQ GIKRLLAAFA PIKRVVE //