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Q03EG0

- XPT_PEDPA

UniProt

Q03EG0 - XPT_PEDPA

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Protein
Xanthine phosphoribosyltransferase
Gene
xpt, PEPE_1374
Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis By similarity.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei27 – 271Xanthine By similarity
Binding sitei156 – 1561Xanthine By similarity

GO - Molecular functioni

  1. xanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. XMP salvage Source: UniProtKB-UniPathway
  2. purine ribonucleoside salvage Source: UniProtKB-HAMAP
  3. xanthine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciPPEN278197:GI4Y-1374-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferase (EC:2.4.2.22)
Short name:
XPRTase
Gene namesi
Name:xpt
Ordered Locus Names:PEPE_1374
OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
ProteomesiUP000000773: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Xanthine phosphoribosyltransferaseUniRule annotation
PRO_0000339725Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi278197.PEPE_1374.

Structurei

3D structure databases

ProteinModelPortaliQ03EG0.
SMRiQ03EG0. Positions 1-189.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 13255-phospho-alpha-D-ribose 1-diphosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000036777.
KOiK03816.
OMAiKTFQKGR.
OrthoDBiEOG6GTZNX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03EG0-1 [UniParc]FASTAAdd to Basket

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MKLLEDKIKS EGIVLPNNVL KVDGFLNHQV DAQLMFEIGK EFGRLFKKQN    50
VTKILTVESS GIAPAVMTGL AMDVPVVFAR KHKSLTLTDD LYTASVYSYT 100
KQTSNQISIS KRFIDEKDRV LIIDDFLANG QAVSGLLDIA DAANIDVVGV 150
GIVIEKTFQK GSQIIKDRDI QLESLARIKA LTDDGQVEFE 190
Length:190
Mass (Da):21,002
Last modified:November 14, 2006 - v1
Checksum:i0645059E98BBEEE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ68412.1.
RefSeqiYP_804854.1. NC_008525.1.

Genome annotation databases

EnsemblBacteriaiABJ68412; ABJ68412; PEPE_1374.
GeneIDi4416989.
KEGGippe:PEPE_1374.
PATRICi22876060. VBIPedPen34213_1298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ68412.1 .
RefSeqi YP_804854.1. NC_008525.1.

3D structure databases

ProteinModelPortali Q03EG0.
SMRi Q03EG0. Positions 1-189.
ModBasei Search...

Protein-protein interaction databases

STRINGi 278197.PEPE_1374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ68412 ; ABJ68412 ; PEPE_1374 .
GeneIDi 4416989.
KEGGi ppe:PEPE_1374.
PATRICi 22876060. VBIPedPen34213_1298.

Phylogenomic databases

eggNOGi COG0503.
HOGENOMi HOG000036777.
KOi K03816.
OMAi KTFQKGR.
OrthoDBi EOG6GTZNX.

Enzyme and pathway databases

UniPathwayi UPA00602 ; UER00658 .
BioCyci PPEN278197:GI4Y-1374-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01184. XPRTase.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01744. XPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25745 / 183-1w.

Entry informationi

Entry nameiXPT_PEDPA
AccessioniPrimary (citable) accession number: Q03EG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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