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Protein

Xanthine phosphoribosyltransferase

Gene

xpt

Organism
Pediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi: XMP biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes XMP from xanthine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Xanthine phosphoribosyltransferase (xpt)
This subpathway is part of the pathway XMP biosynthesis via salvage pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes XMP from xanthine, the pathway XMP biosynthesis via salvage pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei27XanthineUniRule annotation1
Binding sitei156XanthineUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPurine salvage

Enzyme and pathway databases

BioCyciPPEN278197:G1G70-1347-MONOMER
UniPathwayiUPA00602; UER00658

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTaseUniRule annotation
Gene namesi
Name:xptUniRule annotation
Ordered Locus Names:PEPE_1374
OrganismiPediococcus pentosaceus (strain ATCC 25745 / CCUG 21536 / LMG 10740 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
Proteomesi
  • UP000000773 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003397251 – 190Xanthine phosphoribosyltransferaseAdd BLAST190

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi278197.PEPE_1374

Structurei

3D structure databases

ProteinModelPortaliQ03EG0
SMRiQ03EG0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni128 – 1325-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation5

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108UPS Bacteria
COG0503 LUCA
HOGENOMiHOG000036777
KOiK03816
OMAiESQIAVS
OrthoDBiPOG091H02D3

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01184 XPRTase, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR010079 Xanthine_PRibTrfase
PANTHERiPTHR43864:SF1 PTHR43864:SF1, 1 hit
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR01744 XPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q03EG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLEDKIKS EGIVLPNNVL KVDGFLNHQV DAQLMFEIGK EFGRLFKKQN
60 70 80 90 100
VTKILTVESS GIAPAVMTGL AMDVPVVFAR KHKSLTLTDD LYTASVYSYT
110 120 130 140 150
KQTSNQISIS KRFIDEKDRV LIIDDFLANG QAVSGLLDIA DAANIDVVGV
160 170 180 190
GIVIEKTFQK GSQIIKDRDI QLESLARIKA LTDDGQVEFE
Length:190
Mass (Da):21,002
Last modified:November 14, 2006 - v1
Checksum:i0645059E98BBEEE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000422 Genomic DNA Translation: ABJ68412.1
RefSeqiWP_011673640.1, NC_008525.1

Genome annotation databases

EnsemblBacteriaiABJ68412; ABJ68412; PEPE_1374
GeneIDi33061304
KEGGippe:PEPE_1374

Similar proteinsi

Entry informationi

Entry nameiXPT_PEDPA
AccessioniPrimary (citable) accession number: Q03EG0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 14, 2006
Last modified: February 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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