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Q03EG0 (XPT_PEDPA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Xanthine phosphoribosyltransferase

Short name=XPRTase
EC=2.4.2.22
Gene names
Name:xpt
Ordered Locus Names:PEPE_1374
OrganismPediococcus pentosaceus (strain ATCC 25745 / 183-1w) [Complete proteome] [HAMAP]
Taxonomic identifier278197 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus

Protein attributes

Sequence length190 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis By similarity. HAMAP-Rule MF_01184

Catalytic activity

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine. HAMAP-Rule MF_01184

Pathway

Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1. HAMAP-Rule MF_01184

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01184

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01184.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processXMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-HAMAP

xanthine metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionxanthine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 190190Xanthine phosphoribosyltransferase HAMAP-Rule MF_01184
PRO_0000339725

Regions

Region128 – 13255-phospho-alpha-D-ribose 1-diphosphate binding By similarity

Sites

Binding site201Xanthine; via amide nitrogen and carbonyl oxygen By similarity
Binding site271Xanthine By similarity
Binding site1561Xanthine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03EG0 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 0645059E98BBEEE4

FASTA19021,002
        10         20         30         40         50         60 
MKLLEDKIKS EGIVLPNNVL KVDGFLNHQV DAQLMFEIGK EFGRLFKKQN VTKILTVESS 

        70         80         90        100        110        120 
GIAPAVMTGL AMDVPVVFAR KHKSLTLTDD LYTASVYSYT KQTSNQISIS KRFIDEKDRV 

       130        140        150        160        170        180 
LIIDDFLANG QAVSGLLDIA DAANIDVVGV GIVIEKTFQK GSQIIKDRDI QLESLARIKA 

       190 
LTDDGQVEFE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000422 Genomic DNA. Translation: ABJ68412.1.
RefSeqYP_804854.1. NC_008525.1.

3D structure databases

ProteinModelPortalQ03EG0.
SMRQ03EG0. Positions 1-189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING278197.PEPE_1374.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ68412; ABJ68412; PEPE_1374.
GeneID4416989.
KEGGppe:PEPE_1374.
PATRIC22876060. VBIPedPen34213_1298.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0503.
HOGENOMHOG000036777.
KOK03816.
OMAKTFQKGR.
OrthoDBEOG6GTZNX.

Enzyme and pathway databases

BioCycPPEN278197:GI4Y-1374-MONOMER.
UniPathwayUPA00602; UER00658.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01184. XPRTase.
InterProIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01744. XPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameXPT_PEDPA
AccessionPrimary (citable) accession number: Q03EG0
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways