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Q03EG0

- XPT_PEDPA

UniProt

Q03EG0 - XPT_PEDPA

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Protein

Xanthine phosphoribosyltransferase

Gene

xpt

Organism
Pediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.UniRule annotation

Catalytic activityi

XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei20 – 201Xanthine; via amide nitrogen and carbonyl oxygenUniRule annotation
Binding sitei27 – 271XanthineUniRule annotation
Binding sitei156 – 1561XanthineUniRule annotation

GO - Molecular functioni

  1. xanthine phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. purine ribonucleoside salvage Source: UniProtKB-HAMAP
  2. xanthine metabolic process Source: InterPro
  3. XMP salvage Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Purine salvage

Enzyme and pathway databases

BioCyciPPEN278197:GI4Y-1374-MONOMER.
UniPathwayiUPA00602; UER00658.

Names & Taxonomyi

Protein namesi
Recommended name:
Xanthine phosphoribosyltransferaseUniRule annotation (EC:2.4.2.22UniRule annotation)
Short name:
XPRTaseUniRule annotation
Gene namesi
Name:xptUniRule annotation
Ordered Locus Names:PEPE_1374
OrganismiPediococcus pentosaceus (strain ATCC 25745 / 183-1w)
Taxonomic identifieri278197 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus
ProteomesiUP000000773: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 190190Xanthine phosphoribosyltransferasePRO_0000339725Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi278197.PEPE_1374.

Structurei

3D structure databases

ProteinModelPortaliQ03EG0.
SMRiQ03EG0. Positions 1-189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 13255-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0503.
HOGENOMiHOG000036777.
KOiK03816.
OMAiKTFQKGR.
OrthoDBiEOG6GTZNX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01184. XPRTase.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01744. XPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03EG0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLLEDKIKS EGIVLPNNVL KVDGFLNHQV DAQLMFEIGK EFGRLFKKQN
60 70 80 90 100
VTKILTVESS GIAPAVMTGL AMDVPVVFAR KHKSLTLTDD LYTASVYSYT
110 120 130 140 150
KQTSNQISIS KRFIDEKDRV LIIDDFLANG QAVSGLLDIA DAANIDVVGV
160 170 180 190
GIVIEKTFQK GSQIIKDRDI QLESLARIKA LTDDGQVEFE
Length:190
Mass (Da):21,002
Last modified:November 14, 2006 - v1
Checksum:i0645059E98BBEEE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ68412.1.
RefSeqiWP_011673640.1. NC_008525.1.
YP_804854.1. NC_008525.1.

Genome annotation databases

EnsemblBacteriaiABJ68412; ABJ68412; PEPE_1374.
GeneIDi4416989.
KEGGippe:PEPE_1374.
PATRICi22876060. VBIPedPen34213_1298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000422 Genomic DNA. Translation: ABJ68412.1 .
RefSeqi WP_011673640.1. NC_008525.1.
YP_804854.1. NC_008525.1.

3D structure databases

ProteinModelPortali Q03EG0.
SMRi Q03EG0. Positions 1-189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 278197.PEPE_1374.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ68412 ; ABJ68412 ; PEPE_1374 .
GeneIDi 4416989.
KEGGi ppe:PEPE_1374.
PATRICi 22876060. VBIPedPen34213_1298.

Phylogenomic databases

eggNOGi COG0503.
HOGENOMi HOG000036777.
KOi K03816.
OMAi KTFQKGR.
OrthoDBi EOG6GTZNX.

Enzyme and pathway databases

UniPathwayi UPA00602 ; UER00658 .
BioCyci PPEN278197:GI4Y-1374-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01184. XPRTase.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR010079. Xanthine_PRibTrfase.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01744. XPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25745 / 183-1w.

Entry informationi

Entry nameiXPT_PEDPA
AccessioniPrimary (citable) accession number: Q03EG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3