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Q03DZ2 (ALR_PEDPA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase

EC=5.1.1.1
Gene names
Name:alr
Ordered Locus Names:PEPE_1559
OrganismPediococcus pentosaceus (strain ATCC 25745 / 183-1w) [Complete proteome] [HAMAP]
Taxonomic identifier278197 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaePediococcus

Protein attributes

Sequence length374 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 374374Alanine racemase HAMAP-Rule MF_01201
PRO_1000066021

Sites

Active site401Proton acceptor; specific for D-alanine By similarity
Active site2641Proton acceptor; specific for L-alanine By similarity
Binding site1361Substrate By similarity
Binding site3111Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue401N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03DZ2 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 697452066EF59DF4

FASTA37441,263
        10         20         30         40         50         60 
MVVGIHRPSK LVINAEAIRN NVKNEISRLD GHSELFAVVK ANGYGHGIVE TAQFTKQAGA 

        70         80         90        100        110        120 
TGFCVAILDE ALALRDAGLT ETILVLGITD VKYAKLAAEN DISLTVGDQA WLDEATQILN 

       130        140        150        160        170        180 
QKPLKVHLGI DTGMGRIGFQ DGASFKKAAD YLEQSQQFNF EGVFTHFATA DEKDTTYFNL 

       190        200        210        220        230        240 
QVERFNHFIS QLTRRPRYVH VSNTATSLWH AACNGNMIRF GVGIYGMNPS GKTLESPFDL 

       250        260        270        280        290        300 
QPAMSLESEL SFSKLVQKGR SISYGATYTA EEDEWIGTIP IGYADGYERR LQGFHVLIDG 

       310        320        330        340        350        360 
QFCEIVGRIC MDQMMVRLPK SYPVGTKVIL AGKSGEKSIT MTDIAEYAGT INYEITCGFT 

       370 
QRLPRIYTEN GVVN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000422 Genomic DNA. Translation: ABJ68580.1.
RefSeqYP_805022.1. NC_008525.1.

3D structure databases

ProteinModelPortalQ03DZ2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING278197.PEPE_1559.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ68580; ABJ68580; PEPE_1559.
GeneID4417191.
KEGGppe:PEPE_1559.
PATRIC22876428. VBIPedPen34213_1466.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMARTEEWIA.
OrthoDBEOG6PP9NJ.

Enzyme and pathway databases

BioCycPPEN278197:GI4Y-1559-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_PEDPA
AccessionPrimary (citable) accession number: Q03DZ2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways