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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi151 – 1588ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-1-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotation
Ordered Locus Names:LSEI_0001
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001651 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Chromosomal replication initiator protein DnaAPRO_1000048660Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ03D55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000235658.
KOiK02313.
OMAiSHACDKI.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03D55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNLEELWAY LNDKFREELT PVGYSTWIQT AKPVKLTKDK LEIEVPASLH
60 70 80 90 100
KAYWEKNLVT KVVEGVYEFA QLEVDPVIMT KDELQPAPAT DQRPAVEEDD
110 120 130 140 150
QNLTFKAKTH LNPKYTFDHF VIGKGNQMAH AAALAVAEAP GTTYNPLFIY
160 170 180 190 200
GGVGLGKTHL MQAIGNLVLG NNPAANIKYV TSENFANDFI NSIQTKQQEQ
210 220 230 240 250
FRQEYRNVDL LLVDDIQFFG DKEATQEEFF HTFNTLYENM KQIVLTSDRL
260 270 280 290 300
PNEIPKLQER LVSRFNKGLS VDVTPPDLET RIAILRNKAD AEDLSIPDDT
310 320 330 340 350
LSYIAGQIES NVRDLEGALV RVQAFSTMKN EDITTSLAAD ALKALKLDDR
360 370 380 390 400
SGQLTIPQIL NAVAKYFQLT VQDLKGKKRV KQIVIPRQIA MYLAREMTDN
410 420 430 440
SLPKIGQEIG GKDHTTVIHA HEKIMASMTT DENLKAQVIE LRNILKNRG
Length:449
Mass (Da):50,614
Last modified:November 14, 2006 - v1
Checksum:i7BBE720A414702AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ68867.1.
RefSeqiWP_011673926.1. NC_008526.1.
YP_805309.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ68867; ABJ68867; LSEI_0001.
GeneIDi4421687.
KEGGilca:LSEI_0001.
PATRICi22203742. VBILacCas62221_0035.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ68867.1.
RefSeqiWP_011673926.1. NC_008526.1.
YP_805309.1. NC_008526.1.

3D structure databases

ProteinModelPortaliQ03D55.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ68867; ABJ68867; LSEI_0001.
GeneIDi4421687.
KEGGilca:LSEI_0001.
PATRICi22203742. VBILacCas62221_0035.

Phylogenomic databases

HOGENOMiHOG000235658.
KOiK02313.
OMAiSHACDKI.

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-1-MONOMER.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
[Graphical view]
PfamiPF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
[Graphical view]
PRINTSiPR00051. DNAA.
SMARTiSM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiPS01008. DNAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAA_LACC3
AccessioniPrimary (citable) accession number: Q03D55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.