Q03CP2 (ACKA_LACC3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase
EC=2.7.2.1

Alternative name(s):
Acetokinase

Gene names

Name:	ackA
Ordered Locus Names:	LSEI_0166

Organism

Lactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP]

Taxonomic identifier

321967 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 396	396	Acetate kinase HAMAP MF_00020		PRO_1000002238

Sequences

	Sequence		Length	Mass (Da)
	Q03CP2 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 6131C9E55E5EE8FB	FASTA	396	43,261
	10 20 30 40 50 60 MAKILAVNAG SSTLKWKLFD MPAEVQLAEG LVDRLGQPQS KVKIKYGDGQ KYESDTPIAN 70 80 90 100 110 120 YQEAVASLMG NIKALGLVEH LHEITGVGHR VVAGGETFAE SVVVDDATLL QIQNLRDYAP 130 140 150 160 170 180 LHNPVEADYI DVFKKMMPWA TEVAVFDTAF HQTMQPENFL YSIPYDYYKK YGARKYGAHG 190 200 210 220 230 240 TSVRYVSARA AEMLNKPLED LRMIVMHLGS GSSVTAVQGG QSIDTSMGFT PLAGVTMGTR 250 260 270 280 290 300 SGDIDPSLVA YLMKKLDVPD VGQMIHILNN DSGLLGISGI SNDMRDLEAD EDTKPRAKLA 310 320 330 340 350 360 LDIFVNRVVK YVGSYAALMD GVDVLVFTAG IGENGDEIRD KIMRSLDYLG AKIDNDINYK 370 380 390 SHGVEADLST PDSTVKTLLV PTNEELMIVR DVMALS

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 334.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000423 Genomic DNA. Translation: ABJ69030.1.
RefSeq	YP_805472.1. NC_008526.1.
3D structure databases
ProteinModelPortal	Q03CP2.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03CP2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4419118.
GenomeReviews	Gene locus LSEI_0166 in contig CP000423_GR.
KEGG	lca:LSEI_0166.
PATRIC	22204054. VBILacCas62221_0191.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0282.
HOGENOM	HBG285863.
OMA	NPVEADY.
PhylomeDB	Q03CP2.
ProtClustDB	PRK00180.
Enzyme and pathway databases
BioCyc	LCAS321967:LSEI_0166-MONOMER.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA_LACC3

Accession

Primary (citable) accession number: Q03CP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program