Q03BU3 (Q03BU3_LACC3) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 2 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE2 HAMAP MF_00222
Ordered Locus Names:	LSEI_0478

Organism

Lactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP] EMBL ABJ69329.1

Taxonomic identifier

321967 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	299 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222
Ligand	NADP HAMAP MF_00222
Molecular function	Oxidoreductase HAMAP MF_00222 EMBL ABJ69329.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	135 – 139	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	75	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	Q03BU3 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: E96E14AA2AB91CE6	FASTA	299	31,895
	10 20 30 40 50 60 MSLKDEIDGH TVLAGLLAHP AGHSMSPAMY NATFEKLGLN DAYLSFDVDA PELAHALQAM 70 80 90 100 110 120 RSLHFLGGNL SMPNKQKAIP LLDKLSPAAK LIGAVNTIVN DHGVLTGHIT DGTGFMQALS 130 140 150 160 170 180 NDGLDIRGEK MTLAGAGGAG TAIAIQAALD GVREINIFNR RDASWQNAER NVAIINDQTQ 190 200 210 220 230 240 GHATLFALDD QPALKASISD SVIYVDATPA GMKPLETVSN VPDGDWFTPE TIVFDTVYAP 250 260 270 280 290 RETKLMQLAK EAGVNHVYNG INMLINQGAA AFHLWTGLQM PVDYIRETVF GEPAAVAHS

References

[1]

"Comparative genomics of the lactic acid bacteria." Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T. , Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A. Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006) [PubMed: 17030793] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000423 Genomic DNA. Translation: ABJ69329.1.
RefSeq	YP_805771.1. NC_008526.1.
3D structure databases
ProteinModelPortal	Q03BU3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q03BU3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4419962.
GenomeReviews	Gene locus LSEI_0478 in contig CP000423_GR.
KEGG	lca:LSEI_0478.
PATRIC	22204676. VBILacCas62221_0499.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0169.
HOGENOM	HBG553408.
OMA	SIYIDAT.
PhylomeDB	Q03BU3.
ProtClustDB	PRK00258.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00014.
Pfam	PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q03BU3_LACC3

Accession

Primary (citable) accession number: Q03BU3

Entry history

Integrated into UniProtKB/TrEMBL:	November 14, 2006
Last sequence update:	November 14, 2006
Last modified:	December 14, 2011
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)