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Protein

D-alanine--poly(phosphoribitol) ligase subunit 1

Gene

dltA

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp.UniRule annotation

Catalytic activityi

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).UniRule annotation

Pathwayi: lipoteichoic acid biosynthesis

This protein is involved in the pathway lipoteichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoteichoic acid biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00556.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 1UniRule annotation (EC:6.1.1.13UniRule annotation)
Alternative name(s):
D-alanine-D-alanyl carrier protein ligaseUniRule annotation
Short name:
DCLUniRule annotation
D-alanine-activating enzymeUniRule annotation
Short name:
DAEUniRule annotation
Gene namesi
Name:dltAUniRule annotation
Ordered Locus Names:LSEI_0794
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001651 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000255301 – 506D-alanine--poly(phosphoribitol) ligase subunit 1Add BLAST506

Structurei

3D structure databases

ProteinModelPortaliQ03AZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229995.
KOiK03367.
OMAiDEMLATC.

Family and domain databases

HAMAPiMF_00593. DltA. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03AZ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDNVITAID RVAAEHPTRV AYDYEGTQYT YAQLKEGSDR LAGFFAETLP
60 70 80 90 100
EHEPIIVYGG QTFDMVEVFL GLSKSGHAYI PIDTHSPNER ITQVQDVAHT
110 120 130 140 150
PAIIEVAPLP IAVPDVQIIR APALHEAEKT HAPISSLQHA VVGDDNYYII
160 170 180 190 200
FTSGTTGKPK GVQISHDNLL SYVNWNISDF GLKEGVVAMS QPPYSFDLSV
210 220 230 240 250
MDLYPTLVLG GTLKALPKEV TDNFKTLFAT LPKLGLNEWV STPSFAEIAL
260 270 280 290 300
LDPNFNQDNY PDLTHFLFCG EELVNKTAQE LITRFPKATV YNTYGPTETT
310 320 330 340 350
VAVTGMAITQ DIVDQYPRLP IGFAKPDTEI FVVDEQGNQV SAGTEGELMI
360 370 380 390 400
VGPSVSKGYL NNPEKTAKAF FNVGSQRGYR SGDLATMTED GMIFYRGRTD
410 420 430 440 450
FQVKLHGYRI ELEDVDHNLN QVSYIKQAST VPRYNKDHKV AQLIAFAVAK
460 470 480 490 500
PNDFESDMKL TQAVKAELGK MVMEYMIPQR IIYRDKLPLT ANGKVDRKAL

IAEVNH
Length:506
Mass (Da):56,144
Last modified:November 14, 2006 - v1
Checksum:i2138A161D2091C71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ69630.1.
RefSeqiWP_011674281.1. NC_008526.1.
YP_806072.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ69630; ABJ69630; LSEI_0794.
GeneIDi4419382.
KEGGilca:LSEI_0794.
PATRICi22205274. VBILacCas62221_0795.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ69630.1.
RefSeqiWP_011674281.1. NC_008526.1.
YP_806072.1. NC_008526.1.

3D structure databases

ProteinModelPortaliQ03AZ2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ69630; ABJ69630; LSEI_0794.
GeneIDi4419382.
KEGGilca:LSEI_0794.
PATRICi22205274. VBILacCas62221_0795.

Phylogenomic databases

HOGENOMiHOG000229995.
KOiK03367.
OMAiDEMLATC.

Enzyme and pathway databases

UniPathwayiUPA00556.

Family and domain databases

HAMAPiMF_00593. DltA. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR010072. DltA.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR01734. D-ala-DACP-lig. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDLTA_LACC3
AccessioniPrimary (citable) accession number: Q03AZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: November 2, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.