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Protein

D-alanine--poly(phosphoribitol) ligase subunit 2

Gene

dltC

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA.UniRule annotation

Catalytic activityi

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).UniRule annotation

Pathwayi

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-795-MONOMER.
UniPathwayiUPA00556.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 2UniRule annotation (EC:6.1.1.13UniRule annotation)
Alternative name(s):
D-alanyl carrier proteinUniRule annotation
Short name:
DCPUniRule annotation
Gene namesi
Name:dltCUniRule annotation
Ordered Locus Names:LSEI_0796
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181D-alanine--poly(phosphoribitol) ligase subunit 2PRO_1000024914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391O-(pantetheine 4'-phosphoryl)serineUniRule annotation

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.UniRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi321967.LSEI_0796.

Structurei

Secondary structure

1
81
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1815Combined sources
Turni21 – 255Combined sources
Turni31 – 344Combined sources
Helixi40 – 4910Combined sources
Turni64 – 663Combined sources
Beta strandi67 – 693Combined sources
Helixi70 – 789Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HQBNMR-A2-81[»]
ProteinModelPortaliQ03AZ0.
SMRiQ03AZ0. Positions 2-81.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03AZ0.

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0236.
HOGENOMiHOG000040491.
KOiK14188.
OMAiEDISDQM.
OrthoDBiEOG6MWNJM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_00565. DltC.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR003230. DltC.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01688. dltC. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03AZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEAIKNGV LDILADLTGS DDVKTNLDLN LFETGLLDSM GTVQLLLELQ
60 70 80
SQFGVEAPVS EFDRSQWDTP NKIIAKVEQA Q
Length:81
Mass (Da):8,865
Last modified:November 14, 2006 - v1
Checksum:i24DBFC59AD86D47C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ69632.1.
RefSeqiWP_003564027.1. NC_008526.1.
YP_806074.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ69632; ABJ69632; LSEI_0796.
GeneIDi4419384.
KEGGilca:LSEI_0796.
PATRICi22205278. VBILacCas62221_0797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ69632.1.
RefSeqiWP_003564027.1. NC_008526.1.
YP_806074.1. NC_008526.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HQBNMR-A2-81[»]
ProteinModelPortaliQ03AZ0.
SMRiQ03AZ0. Positions 2-81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi321967.LSEI_0796.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ69632; ABJ69632; LSEI_0796.
GeneIDi4419384.
KEGGilca:LSEI_0796.
PATRICi22205278. VBILacCas62221_0797.

Phylogenomic databases

eggNOGiCOG0236.
HOGENOMiHOG000040491.
KOiK14188.
OMAiEDISDQM.
OrthoDBiEOG6MWNJM.

Enzyme and pathway databases

UniPathwayiUPA00556.
BioCyciLCAS321967:GH4S-795-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ03AZ0.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_00565. DltC.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR003230. DltC.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01688. dltC. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiDLTC_LACC3
AccessioniPrimary (citable) accession number: Q03AZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: May 27, 2015
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.