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Protein

D-alanine--poly(phosphoribitol) ligase subunit 2

Gene

dltC

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA.UniRule annotation

Catalytic activityi

ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate + O-D-alanyl-poly(ribitol phosphate).UniRule annotation

Pathway: lipoteichoic acid biosynthesis

This protein is involved in the pathway lipoteichoic acid biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway lipoteichoic acid biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-795-MONOMER.
UniPathwayiUPA00556.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--poly(phosphoribitol) ligase subunit 2UniRule annotation (EC:6.1.1.13UniRule annotation)
Alternative name(s):
D-alanyl carrier proteinUniRule annotation
Short name:
DCPUniRule annotation
Gene namesi
Name:dltCUniRule annotation
Ordered Locus Names:LSEI_0796
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 8181D-alanine--poly(phosphoribitol) ligase subunit 2PRO_1000024914Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei39 – 391O-(pantetheine 4'-phosphoryl)serineUniRule annotation

Post-translational modificationi

4'-phosphopantetheine is transferred from CoA to a specific serine of apo-DCP.UniRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Structurei

Secondary structure

1
81
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi4 – 1815Combined sources
Turni21 – 255Combined sources
Turni31 – 344Combined sources
Helixi40 – 4910Combined sources
Turni64 – 663Combined sources
Beta strandi67 – 693Combined sources
Helixi70 – 789Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HQBNMR-A2-81[»]
ProteinModelPortaliQ03AZ0.
SMRiQ03AZ0. Positions 2-81.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ03AZ0.

Family & Domainsi

Sequence similaritiesi

Contains 1 acyl carrier domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0236.
HOGENOMiHOG000040491.
KOiK14188.
OMAiEDISDQM.
OrthoDBiEOG6MWNJM.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_00565. DltC.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR003230. DltC.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01688. dltC. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03AZ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEAIKNGV LDILADLTGS DDVKTNLDLN LFETGLLDSM GTVQLLLELQ
60 70 80
SQFGVEAPVS EFDRSQWDTP NKIIAKVEQA Q
Length:81
Mass (Da):8,865
Last modified:November 14, 2006 - v1
Checksum:i24DBFC59AD86D47C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ69632.1.
RefSeqiWP_003564027.1. NC_008526.1.
YP_806074.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ69632; ABJ69632; LSEI_0796.
GeneIDi4419384.
KEGGilca:LSEI_0796.
PATRICi22205278. VBILacCas62221_0797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ69632.1.
RefSeqiWP_003564027.1. NC_008526.1.
YP_806074.1. NC_008526.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1HQBNMR-A2-81[»]
ProteinModelPortaliQ03AZ0.
SMRiQ03AZ0. Positions 2-81.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABJ69632; ABJ69632; LSEI_0796.
GeneIDi4419384.
KEGGilca:LSEI_0796.
PATRICi22205278. VBILacCas62221_0797.

Phylogenomic databases

eggNOGiCOG0236.
HOGENOMiHOG000040491.
KOiK14188.
OMAiEDISDQM.
OrthoDBiEOG6MWNJM.

Enzyme and pathway databases

UniPathwayiUPA00556.
BioCyciLCAS321967:GH4S-795-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ03AZ0.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
HAMAPiMF_00565. DltC.
InterProiIPR009081. Acyl_carrier_prot-like.
IPR003230. DltC.
[Graphical view]
PfamiPF00550. PP-binding. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01688. dltC. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiDLTC_LACC3
AccessioniPrimary (citable) accession number: Q03AZ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 24, 2015
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.