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Q03AT8

- SYL_LACC3

UniProt

Q03AT8 - SYL_LACC3

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei578 – 5781ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-882-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LSEI_0883
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 803803Leucine--tRNA ligasePRO_1000009358Add
BLAST

Proteomic databases

PRIDEiQ03AT8.

Interactioni

Protein-protein interaction databases

STRINGi321967.LSEI_0883.

Structurei

3D structure databases

ProteinModelPortaliQ03AT8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi575 – 5795"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiNENGVEG.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03AT8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYDHHEIDK KWQRYWAEHN EFNTTTDPKK PNYYALDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI VARMKRMQGF NVLHPMGWDA FGLPAEQYAL NTGHNPKTFT
110 120 130 140 150
KQNIETFKRQ INSLGFSYDW NREINTTDPN YYKWTQWIFE QLYKHGLAYE
160 170 180 190 200
AEVPVNWSPD LGTVVANEEV IDGKTERGGF PVVRKPMRQW MLKITAYAEK
210 220 230 240 250
LLTDLDDLDW PESIKQMQRN WIGKSTGAQI TFRVTDSHEP FDVFTTRPDT
260 270 280 290 300
LFGATYVVMA PEHELVQKIT TPAQQAVVDA YIDEAAHKSD LDRTALDKEK
310 320 330 340 350
TGVWTGAYAT NPVNGEKLPI WISDYVLASY GTGAIMSVPA HDDRDYAFAK
360 370 380 390 400
KFGIEIKPVI EGGNVDEAAY TGDGVHINSG FLDGLNEHDA IDRMIKWLED
410 420 430 440 450
KGIGSAKINY KLRDWVFSRQ RYWGEPIPVI HWEDGETTLV PEDELPLTLP
460 470 480 490 500
EEADIKPSGT GESPLANLTD WVNVVDKNGR KGKRETNTMP QWAGSSWYFL
510 520 530 540 550
RFVDPHNKEA LADYDKLKAW MPVDLYIGGA EHAVLHLLYA RFWNLFLYDI
560 570 580 590 600
GAIPNKEPFQ RLFNQGMILG DNHEKMSKSK GNVVNPDDVV DEYGADTLRL
610 620 630 640 650
YEMFMGPLDA GIAWSTKGLA GARKFLDRVW SAFIDDEGKL RDRITTINDG
660 670 680 690 700
RLDKVYNETV KKVTEDYDAL HFNTAISQMM VFINSARKDD DLPLEYVEGF
710 720 730 740 750
VKMLAPIAPH LMEEIWSRLG HDHSLTYAPW PSYDESKIKT DTYDMMIQVN
760 770 780 790 800
GKLRGSITAD VNESDDEIKQ AALANDNVQK FTAGKDIKKI IVVPRKIVNI

VAK
Length:803
Mass (Da):91,527
Last modified:November 14, 2006 - v1
Checksum:i487E45B7E7F7BA4B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ69684.1.
RefSeqiYP_806126.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ69684; ABJ69684; LSEI_0883.
GeneIDi4421698.
KEGGilca:LSEI_0883.
PATRICi22205459. VBILacCas62221_0853.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ69684.1 .
RefSeqi YP_806126.1. NC_008526.1.

3D structure databases

ProteinModelPortali Q03AT8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321967.LSEI_0883.

Proteomic databases

PRIDEi Q03AT8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ69684 ; ABJ69684 ; LSEI_0883 .
GeneIDi 4421698.
KEGGi lca:LSEI_0883.
PATRICi 22205459. VBILacCas62221_0853.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi NENGVEG.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LCAS321967:GH4S-882-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiSYL_LACC3
AccessioniPrimary (citable) accession number: Q03AT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3