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Q03AT8

- SYL_LACC3

UniProt

Q03AT8 - SYL_LACC3

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei578 – 5781ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCAS321967:GH4S-882-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:LSEI_0883
    OrganismiLactobacillus casei (strain ATCC 334)
    Taxonomic identifieri321967 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001651: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 803803Leucine--tRNA ligasePRO_1000009358Add
    BLAST

    Proteomic databases

    PRIDEiQ03AT8.

    Interactioni

    Protein-protein interaction databases

    STRINGi321967.LSEI_0883.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03AT8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi40 – 5112"HIGH" regionAdd
    BLAST
    Motifi575 – 5795"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    HOGENOMiHOG000200748.
    KOiK01869.
    OMAiNENGVEG.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03AT8-1 [UniParc]FASTAAdd to Basket

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    MAYDHHEIDK KWQRYWAEHN EFNTTTDPKK PNYYALDMFP YPSGQGLHVG    50
    HPEGYTATDI VARMKRMQGF NVLHPMGWDA FGLPAEQYAL NTGHNPKTFT 100
    KQNIETFKRQ INSLGFSYDW NREINTTDPN YYKWTQWIFE QLYKHGLAYE 150
    AEVPVNWSPD LGTVVANEEV IDGKTERGGF PVVRKPMRQW MLKITAYAEK 200
    LLTDLDDLDW PESIKQMQRN WIGKSTGAQI TFRVTDSHEP FDVFTTRPDT 250
    LFGATYVVMA PEHELVQKIT TPAQQAVVDA YIDEAAHKSD LDRTALDKEK 300
    TGVWTGAYAT NPVNGEKLPI WISDYVLASY GTGAIMSVPA HDDRDYAFAK 350
    KFGIEIKPVI EGGNVDEAAY TGDGVHINSG FLDGLNEHDA IDRMIKWLED 400
    KGIGSAKINY KLRDWVFSRQ RYWGEPIPVI HWEDGETTLV PEDELPLTLP 450
    EEADIKPSGT GESPLANLTD WVNVVDKNGR KGKRETNTMP QWAGSSWYFL 500
    RFVDPHNKEA LADYDKLKAW MPVDLYIGGA EHAVLHLLYA RFWNLFLYDI 550
    GAIPNKEPFQ RLFNQGMILG DNHEKMSKSK GNVVNPDDVV DEYGADTLRL 600
    YEMFMGPLDA GIAWSTKGLA GARKFLDRVW SAFIDDEGKL RDRITTINDG 650
    RLDKVYNETV KKVTEDYDAL HFNTAISQMM VFINSARKDD DLPLEYVEGF 700
    VKMLAPIAPH LMEEIWSRLG HDHSLTYAPW PSYDESKIKT DTYDMMIQVN 750
    GKLRGSITAD VNESDDEIKQ AALANDNVQK FTAGKDIKKI IVVPRKIVNI 800
    VAK 803
    Length:803
    Mass (Da):91,527
    Last modified:November 14, 2006 - v1
    Checksum:i487E45B7E7F7BA4B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ69684.1.
    RefSeqiYP_806126.1. NC_008526.1.

    Genome annotation databases

    EnsemblBacteriaiABJ69684; ABJ69684; LSEI_0883.
    GeneIDi4421698.
    KEGGilca:LSEI_0883.
    PATRICi22205459. VBILacCas62221_0853.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ69684.1 .
    RefSeqi YP_806126.1. NC_008526.1.

    3D structure databases

    ProteinModelPortali Q03AT8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321967.LSEI_0883.

    Proteomic databases

    PRIDEi Q03AT8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ69684 ; ABJ69684 ; LSEI_0883 .
    GeneIDi 4421698.
    KEGGi lca:LSEI_0883.
    PATRICi 22205459. VBILacCas62221_0853.

    Phylogenomic databases

    eggNOGi COG0495.
    HOGENOMi HOG000200748.
    KOi K01869.
    OMAi NENGVEG.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci LCAS321967:GH4S-882-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 334.

    Entry informationi

    Entry nameiSYL_LACC3
    AccessioniPrimary (citable) accession number: Q03AT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3