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Q03AR6 (UPPP_LACC3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:LSEI_0906
OrganismLactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP]
Taxonomic identifier321967 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length272 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 272272Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000290716

Regions

Transmembrane2 – 2221Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane82 – 10221Helical; Potential
Transmembrane110 – 13021Helical; Potential
Transmembrane185 – 20521Helical; Potential
Transmembrane224 – 24421Helical; Potential
Transmembrane252 – 27221Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q03AR6 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: E6EA3BC67CEAAC17

FASTA27230,142
        10         20         30         40         50         60 
MFDIIKAVII GIVEGLTEFL PISSTGHIDL VNHVIKLSQS QDFINMFEYV IQFGAILAVI 

        70         80         90        100        110        120 
LLYFNKLNPF SKPTAKARNA TWQLWAKVII AVLPSVVVGL PLNNWMDEHL HTPLVVATTL 

       130        140        150        160        170        180 
IIYGVLFIIL ENYLKNKNAH ITTLADITYQ TALLIGLFQV LSIVPGTSRS GATILGALLI 

       190        200        210        220        230        240 
GTSRYVATEF SFFLAIPTMV GVSILKIGKY LWQGNGFSGE QWAVLMTGSI VSFLVAIVAI 

       250        260        270 
KWLLKFVQTH DFKPFGWYRI ALGAIVLLVM FI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000423 Genomic DNA. Translation: ABJ69706.1.
RefSeqYP_806148.1. NC_008526.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321967.LSEI_0906.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ69706; ABJ69706; LSEI_0906.
GeneID4419303.
KEGGlca:LSEI_0906.
PATRIC22205505. VBILacCas62221_0875.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMATEVNRIT.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycLCAS321967:GH4S-905-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_LACC3
AccessionPrimary (citable) accession number: Q03AR6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families