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Q03A25

- UPP_LACC3

UniProt

Q03A25 - UPP_LACC3

Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

    Cofactori

    Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

    Enzyme regulationi

    Allosterically activated by GTP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei79 – 7915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei104 – 10415-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
    Binding sitei194 – 1941Uracil; via amide nitrogenUniRule annotation
    Binding sitei200 – 20015-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. UMP salvage Source: UniProtKB-UniPathway
    2. uracil salvage Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Ligandi

    GTP-binding, Magnesium, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLCAS321967:GH4S-1158-MONOMER.
    UniPathwayiUPA00574; UER00636.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
    Alternative name(s):
    UMP pyrophosphorylaseUniRule annotation
    UPRTaseUniRule annotation
    Gene namesi
    Name:uppUniRule annotation
    Ordered Locus Names:LSEI_1159
    OrganismiLactobacillus casei (strain ATCC 334)
    Taxonomic identifieri321967 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000001651: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 209209Uracil phosphoribosyltransferasePRO_1000053729Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi321967.LSEI_1159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03A25.
    SMRiQ03A25. Positions 2-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni131 – 13995-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
    Regioni199 – 2013Uracil bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the UPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0035.
    HOGENOMiHOG000262754.
    KOiK00761.
    OMAiTTRHIET.
    OrthoDBiEOG6HF5WX.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01218_B. Upp_B.
    InterProiIPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.
    TIGRFAMsiTIGR01091. upp. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q03A25-1 [UniParc]FASTAAdd to Basket

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    MGKFTVLNHP LIQHKLTLIR DKHAGTKEFR EIANEIAELM VYEITRDLPL    50
    ESIEIETPMG KTIQKQLAGK KLAVVPILRA GLGMVDGVLR LIPAAKVGHI 100
    GMYRDEKTLK PHEYFVKMPP DIEQRDLIIV DPMLATGGSA NMAIEALKKR 150
    GATSMRLVVL VAAPEGVKAV QAANPDVDIY AAALDDHLNE NGYIVPGLGD 200
    AGDRLFGTK 209
    Length:209
    Mass (Da):22,809
    Last modified:November 14, 2006 - v1
    Checksum:i7EE8C99FEFF2E5EF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ69947.1.
    RefSeqiYP_806389.1. NC_008526.1.

    Genome annotation databases

    EnsemblBacteriaiABJ69947; ABJ69947; LSEI_1159.
    GeneIDi4421616.
    KEGGilca:LSEI_1159.
    PATRICi22206027. VBILacCas62221_1132.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000423 Genomic DNA. Translation: ABJ69947.1 .
    RefSeqi YP_806389.1. NC_008526.1.

    3D structure databases

    ProteinModelPortali Q03A25.
    SMRi Q03A25. Positions 2-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 321967.LSEI_1159.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABJ69947 ; ABJ69947 ; LSEI_1159 .
    GeneIDi 4421616.
    KEGGi lca:LSEI_1159.
    PATRICi 22206027. VBILacCas62221_1132.

    Phylogenomic databases

    eggNOGi COG0035.
    HOGENOMi HOG000262754.
    KOi K00761.
    OMAi TTRHIET.
    OrthoDBi EOG6HF5WX.

    Enzyme and pathway databases

    UniPathwayi UPA00574 ; UER00636 .
    BioCyci LCAS321967:GH4S-1158-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01218_B. Upp_B.
    InterProi IPR029057. PRTase-like.
    IPR005765. Ura_phspho_trans.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    TIGRFAMsi TIGR01091. upp. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 334.

    Entry informationi

    Entry nameiUPP_LACC3
    AccessioniPrimary (citable) accession number: Q03A25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Allosteric enzyme, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3