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Q03A25

- UPP_LACC3

UniProt

Q03A25 - UPP_LACC3

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Protein

Uracil phosphoribosyltransferase

Gene

upp

Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.UniRule annotation

Enzyme regulationi

Allosterically activated by GTP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 7915-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei104 – 10415-phospho-alpha-D-ribose 1-diphosphateUniRule annotation
Binding sitei194 – 1941Uracil; via amide nitrogenUniRule annotation
Binding sitei200 – 20015-phospho-alpha-D-ribose 1-diphosphateUniRule annotation

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-1158-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Alternative name(s):
UMP pyrophosphorylaseUniRule annotation
UPRTaseUniRule annotation
Gene namesi
Name:uppUniRule annotation
Ordered Locus Names:LSEI_1159
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Uracil phosphoribosyltransferasePRO_1000053729Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321967.LSEI_1159.

Structurei

3D structure databases

ProteinModelPortaliQ03A25.
SMRiQ03A25. Positions 2-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 13995-phospho-alpha-D-ribose 1-diphosphate bindingUniRule annotation
Regioni199 – 2013Uracil bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0035.
HOGENOMiHOG000262754.
KOiK00761.
OMAiTTRHIET.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03A25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKFTVLNHP LIQHKLTLIR DKHAGTKEFR EIANEIAELM VYEITRDLPL
60 70 80 90 100
ESIEIETPMG KTIQKQLAGK KLAVVPILRA GLGMVDGVLR LIPAAKVGHI
110 120 130 140 150
GMYRDEKTLK PHEYFVKMPP DIEQRDLIIV DPMLATGGSA NMAIEALKKR
160 170 180 190 200
GATSMRLVVL VAAPEGVKAV QAANPDVDIY AAALDDHLNE NGYIVPGLGD

AGDRLFGTK
Length:209
Mass (Da):22,809
Last modified:November 14, 2006 - v1
Checksum:i7EE8C99FEFF2E5EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ69947.1.
RefSeqiYP_806389.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ69947; ABJ69947; LSEI_1159.
GeneIDi4421616.
KEGGilca:LSEI_1159.
PATRICi22206027. VBILacCas62221_1132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ69947.1 .
RefSeqi YP_806389.1. NC_008526.1.

3D structure databases

ProteinModelPortali Q03A25.
SMRi Q03A25. Positions 2-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321967.LSEI_1159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ69947 ; ABJ69947 ; LSEI_1159 .
GeneIDi 4421616.
KEGGi lca:LSEI_1159.
PATRICi 22206027. VBILacCas62221_1132.

Phylogenomic databases

eggNOGi COG0035.
HOGENOMi HOG000262754.
KOi K00761.
OMAi TTRHIET.
OrthoDBi EOG6HF5WX.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00636 .
BioCyci LCAS321967:GH4S-1158-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01218_B. Upp_B.
InterProi IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01091. upp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiUPP_LACC3
AccessioniPrimary (citable) accession number: Q03A25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3