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Q03A25 (UPP_LACC3) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uracil phosphoribosyltransferase

EC=2.4.2.9
Alternative name(s):
UMP pyrophosphorylase
UPRTase
Gene names
Name:upp
Ordered Locus Names:LSEI_1159
OrganismLactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP]
Taxonomic identifier321967 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length209 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity. HAMAP-Rule MF_01218

Catalytic activity

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01218

Cofactor

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.

Enzyme regulation

Allosterically activated by GTP By similarity. HAMAP-Rule MF_01218

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1. HAMAP-Rule MF_01218

Sequence similarities

Belongs to the UPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 209209Uracil phosphoribosyltransferase HAMAP-Rule MF_01218
PRO_1000053729

Regions

Region131 – 13995-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Region199 – 2013Uracil binding By similarity

Sites

Binding site7915-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding site10415-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding site1941Uracil; via amide nitrogen By similarity
Binding site20015-phospho-alpha-D-ribose 1-diphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q03A25 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 7EE8C99FEFF2E5EF

FASTA20922,809
        10         20         30         40         50         60 
MGKFTVLNHP LIQHKLTLIR DKHAGTKEFR EIANEIAELM VYEITRDLPL ESIEIETPMG 

        70         80         90        100        110        120 
KTIQKQLAGK KLAVVPILRA GLGMVDGVLR LIPAAKVGHI GMYRDEKTLK PHEYFVKMPP 

       130        140        150        160        170        180 
DIEQRDLIIV DPMLATGGSA NMAIEALKKR GATSMRLVVL VAAPEGVKAV QAANPDVDIY 

       190        200 
AAALDDHLNE NGYIVPGLGD AGDRLFGTK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000423 Genomic DNA. Translation: ABJ69947.1.
RefSeqYP_806389.1. NC_008526.1.

3D structure databases

ProteinModelPortalQ03A25.
SMRQ03A25. Positions 2-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321967.LSEI_1159.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ69947; ABJ69947; LSEI_1159.
GeneID4421616.
KEGGlca:LSEI_1159.
PATRIC22206027. VBILacCas62221_1132.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0035.
HOGENOMHOG000262754.
KOK00761.
OMATTRHIET.
OrthoDBEOG6HF5WX.

Enzyme and pathway databases

BioCycLCAS321967:GH4S-1158-MONOMER.
UniPathwayUPA00574; UER00636.

Family and domain databases

Gene3D3.40.50.2020. 1 hit.
HAMAPMF_01218_B. Upp_B.
InterProIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMSSF53271. SSF53271. 1 hit.
TIGRFAMsTIGR01091. upp. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPP_LACC3
AccessionPrimary (citable) accession number: Q03A25
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways