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Q03A25

- UPP_LACC3

UniProt

Q03A25 - UPP_LACC3

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Protein
Uracil phosphoribosyltransferase
Gene
upp, LSEI_1159
Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate By similarity.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP By similarity.

Enzyme regulationi

Allosterically activated by GTP By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei79 – 7915-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding sitei104 – 10415-phospho-alpha-D-ribose 1-diphosphate By similarity
Binding sitei194 – 1941Uracil; via amide nitrogen By similarity
Binding sitei200 – 20015-phospho-alpha-D-ribose 1-diphosphate By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. UMP salvage Source: UniProtKB-UniPathway
  2. uracil salvage Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

GTP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-1158-MONOMER.
UniPathwayiUPA00574; UER00636.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil phosphoribosyltransferase (EC:2.4.2.9)
Alternative name(s):
UMP pyrophosphorylase
UPRTase
Gene namesi
Name:upp
Ordered Locus Names:LSEI_1159
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 209209Uracil phosphoribosyltransferaseUniRule annotation
PRO_1000053729Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321967.LSEI_1159.

Structurei

3D structure databases

ProteinModelPortaliQ03A25.
SMRiQ03A25. Positions 2-209.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni131 – 13995-phospho-alpha-D-ribose 1-diphosphate binding By similarity
Regioni199 – 2013Uracil binding By similarity

Sequence similaritiesi

Belongs to the UPRTase family.

Phylogenomic databases

eggNOGiCOG0035.
HOGENOMiHOG000262754.
KOiK00761.
OMAiTTRHIET.
OrthoDBiEOG6HF5WX.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01218_B. Upp_B.
InterProiIPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.
TIGRFAMsiTIGR01091. upp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03A25-1 [UniParc]FASTAAdd to Basket

« Hide

MGKFTVLNHP LIQHKLTLIR DKHAGTKEFR EIANEIAELM VYEITRDLPL    50
ESIEIETPMG KTIQKQLAGK KLAVVPILRA GLGMVDGVLR LIPAAKVGHI 100
GMYRDEKTLK PHEYFVKMPP DIEQRDLIIV DPMLATGGSA NMAIEALKKR 150
GATSMRLVVL VAAPEGVKAV QAANPDVDIY AAALDDHLNE NGYIVPGLGD 200
AGDRLFGTK 209
Length:209
Mass (Da):22,809
Last modified:November 14, 2006 - v1
Checksum:i7EE8C99FEFF2E5EF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ69947.1.
RefSeqiYP_806389.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ69947; ABJ69947; LSEI_1159.
GeneIDi4421616.
KEGGilca:LSEI_1159.
PATRICi22206027. VBILacCas62221_1132.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ69947.1 .
RefSeqi YP_806389.1. NC_008526.1.

3D structure databases

ProteinModelPortali Q03A25.
SMRi Q03A25. Positions 2-209.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321967.LSEI_1159.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ69947 ; ABJ69947 ; LSEI_1159 .
GeneIDi 4421616.
KEGGi lca:LSEI_1159.
PATRICi 22206027. VBILacCas62221_1132.

Phylogenomic databases

eggNOGi COG0035.
HOGENOMi HOG000262754.
KOi K00761.
OMAi TTRHIET.
OrthoDBi EOG6HF5WX.

Enzyme and pathway databases

UniPathwayi UPA00574 ; UER00636 .
BioCyci LCAS321967:GH4S-1158-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01218_B. Upp_B.
InterProi IPR029057. PRTase-like.
IPR005765. Ura_phspho_trans.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
TIGRFAMsi TIGR01091. upp. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiUPP_LACC3
AccessioniPrimary (citable) accession number: Q03A25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Allosteric enzyme, Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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