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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Lactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:LSEI_1270
OrganismiLactobacillus paracasei (strain ATCC 334 / BCRC 17002 / CIP 107868 / KCTC 3260 / NRRL B-441)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000001651 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei53 – 73HelicalUniRule annotationAdd BLAST21
Transmembranei77 – 97HelicalUniRule annotationAdd BLAST21
Transmembranei121 – 141HelicalUniRule annotationAdd BLAST21
Transmembranei144 – 164HelicalUniRule annotationAdd BLAST21
Transmembranei175 – 195HelicalUniRule annotationAdd BLAST21
Transmembranei200 – 220HelicalUniRule annotationAdd BLAST21
Transmembranei226 – 246HelicalUniRule annotationAdd BLAST21
Transmembranei251 – 271HelicalUniRule annotationAdd BLAST21
Transmembranei301 – 321HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029951 – 321Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST321

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q039R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLAQMLIPM VSAFAITIMF MPLFIGYMRY KKEGQVIREE GPSWHEKKSG
60 70 80 90 100
TPTMGGLIFI AAIIVSAIWV GIWQHQLTLS VWVSLFILVL YGLLGFYDDF
110 120 130 140 150
EKLVHHRNEG LKAWQKLAGQ ILGAIIFLIA YFHEGFDHTL WVPIIGNVSA
160 170 180 190 200
AWFYVLFVIV WLVGFSNAVN LTDGLDGLVA GQTTISFGTY AIIAAHDGRT
210 220 230 240 250
DVLIVCLVTI GAMLGFLMFN HKPAQIFMGD LGSLALGGML AVVAILLHRE
260 270 280 290 300
WSLLLIGIIY VTETASVILQ VGSFKLTGKR IFLMSPIHHH FEMKGWSEWQ
310 320
IDLTFWLVGL IGSGIYLAFF L
Length:321
Mass (Da):35,827
Last modified:November 14, 2006 - v1
Checksum:iB1B4CB163A326D8A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000423 Genomic DNA. Translation: ABJ70053.1.
RefSeqiWP_003594376.1. NC_008526.1.
YP_806495.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ70053; ABJ70053; LSEI_1270.
GeneIDi4419566.
KEGGilca:LSEI_1270.
PATRICifig|321967.11.peg.1246.

Similar proteinsi

Entry informationi

Entry nameiMRAY_LACP3
AccessioniPrimary (citable) accession number: Q039R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families