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Q039N7

- DEF_LACC3

UniProt

Q039N7 - DEF_LACC3

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Protein

Peptide deformylase

Gene
def, LSEI_1303
Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi111 – 1111Iron By similarity
Metal bindingi154 – 1541Iron By similarity
Active sitei155 – 1551 By similarity
Metal bindingi158 – 1581Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-1302-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:LSEI_1303
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 184184Peptide deformylaseUniRule annotationPRO_0000301043Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi321967.LSEI_1303.

Structurei

3D structure databases

ProteinModelPortaliQ039N7.
SMRiQ039N7. Positions 1-184.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243507.
KOiK01462.
OMAiSQDPKIA.
OrthoDBiEOG6PZXGQ.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q039N7-1 [UniParc]FASTAAdd to Basket

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MYLMKDITRD GAKVLRETAK PVTFPLSDED KQLAHDMMAY LVISQDEEQN    50
EKYHLRPGVG LAAPQVGQSK AMAAVLVPGD DNEILFKEVL INPRIISNSV 100
QHAALAEGEG CLSVDKDVPG YVVRADRITI SYQNEAGEHK KIRLKNYPAI 150
VCQHEIDHLN GVLFYDHINK EHPFTIDPDA VIIK 184
Length:184
Mass (Da):20,586
Last modified:November 14, 2006 - v1
Checksum:i381BAEB784D5DA15
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ70085.1.
RefSeqiYP_806527.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ70085; ABJ70085; LSEI_1303.
GeneIDi4419664.
KEGGilca:LSEI_1303.
PATRICi22206328. VBILacCas62221_1282.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ70085.1 .
RefSeqi YP_806527.1. NC_008526.1.

3D structure databases

ProteinModelPortali Q039N7.
SMRi Q039N7. Positions 1-184.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321967.LSEI_1303.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ70085 ; ABJ70085 ; LSEI_1303 .
GeneIDi 4419664.
KEGGi lca:LSEI_1303.
PATRICi 22206328. VBILacCas62221_1282.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243507.
KOi K01462.
OMAi SQDPKIA.
OrthoDBi EOG6PZXGQ.

Enzyme and pathway databases

BioCyci LCAS321967:GH4S-1302-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiDEF_LACC3
AccessioniPrimary (citable) accession number: Q039N7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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