Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q039N7 (DEF_LACC3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Peptide deformylase

Short name=PDF
EC=3.5.1.88
Alternative name(s):
Polypeptide deformylase
Gene names
Name:def
Ordered Locus Names:LSEI_1303
OrganismLactobacillus casei (strain ATCC 334) [Complete proteome] [HAMAP]
Taxonomic identifier321967 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity. HAMAP-Rule MF_00163

Catalytic activity

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide. HAMAP-Rule MF_00163

Cofactor

Binds 1 Fe2+ ion By similarity. HAMAP-Rule MF_00163

Sequence similarities

Belongs to the polypeptide deformylase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   LigandIron
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functioniron ion binding

Inferred from electronic annotation. Source: InterPro

peptide deformylase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184Peptide deformylase HAMAP-Rule MF_00163
PRO_0000301043

Sites

Active site1551 By similarity
Metal binding1111Iron By similarity
Metal binding1541Iron By similarity
Metal binding1581Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q039N7 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 381BAEB784D5DA15

FASTA18420,586
        10         20         30         40         50         60 
MYLMKDITRD GAKVLRETAK PVTFPLSDED KQLAHDMMAY LVISQDEEQN EKYHLRPGVG 

        70         80         90        100        110        120 
LAAPQVGQSK AMAAVLVPGD DNEILFKEVL INPRIISNSV QHAALAEGEG CLSVDKDVPG 

       130        140        150        160        170        180 
YVVRADRITI SYQNEAGEHK KIRLKNYPAI VCQHEIDHLN GVLFYDHINK EHPFTIDPDA 


VIIK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000423 Genomic DNA. Translation: ABJ70085.1.
RefSeqYP_806527.1. NC_008526.1.

3D structure databases

ProteinModelPortalQ039N7.
SMRQ039N7. Positions 1-184.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING321967.LSEI_1303.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABJ70085; ABJ70085; LSEI_1303.
GeneID4419664.
KEGGlca:LSEI_1303.
PATRIC22206328. VBILacCas62221_1282.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0242.
HOGENOMHOG000243507.
KOK01462.
OMASQDPKIA.
OrthoDBEOG6PZXGQ.

Enzyme and pathway databases

BioCycLCAS321967:GH4S-1302-MONOMER.

Family and domain databases

Gene3D3.90.45.10. 1 hit.
HAMAPMF_00163. Pep_deformylase.
InterProIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERPTHR10458. PTHR10458. 1 hit.
PfamPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFPIRSF004749. Pep_def. 1 hit.
PRINTSPR01576. PDEFORMYLASE.
SUPFAMSSF56420. SSF56420. 1 hit.
TIGRFAMsTIGR00079. pept_deformyl. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDEF_LACC3
AccessionPrimary (citable) accession number: Q039N7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: May 14, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families