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Protein

AT-rich interactive domain-containing protein 5A

Gene

ARID5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison.1 Publication

GO - Molecular functioni

  • DNA binding Source: GDB
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 5A
Short name:
ARID domain-containing protein 5A
Alternative name(s):
Modulator recognition factor 1
Short name:
MRF-1
Gene namesi
Name:ARID5A
Synonyms:MRF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:17361. ARID5A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134937822.

Polymorphism and mutation databases

BioMutaiARID5A.
DMDMi148840818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 594594AT-rich interactive domain-containing protein 5APRO_0000288930Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei289 – 2891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03989.
PaxDbiQ03989.
PeptideAtlasiQ03989.
PRIDEiQ03989.

PTM databases

iPTMnetiQ03989.
PhosphoSiteiQ03989.

Expressioni

Gene expression databases

BgeeiQ03989.
CleanExiHS_ARID5A.
ExpressionAtlasiQ03989. baseline and differential.
GenevisibleiQ03989. HS.

Organism-specific databases

HPAiHPA002860.
HPA023879.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542533EBI-948603,EBI-930964

Protein-protein interaction databases

BioGridi116074. 20 interactions.
IntActiQ03989. 2 interactions.
MINTiMINT-2868767.
STRINGi9606.ENSP00000350078.

Structurei

3D structure databases

ProteinModelPortaliQ03989.
SMRiQ03989. Positions 55-161.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini55 – 14793ARIDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00840000129864.
HOGENOMiHOG000034050.
HOVERGENiHBG062210.
InParanoidiQ03989.
OMAiGLMHFPP.
OrthoDBiEOG7992PR.
PhylomeDBiQ03989.
TreeFamiTF324725.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03989-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPVKGNRK QSTEGDALDP PASPKPAGKQ NGIQNPISLE DSPEAGGERE
60 70 80 90 100
EEQEREEEQA FLVSLYKFMK ERHTPIERVP HLGFKQINLW KIYKAVEKLG
110 120 130 140 150
AYELVTGRRL WKNVYDELGG SPGSTSAATC TRRHYERLVL PYVRHLKGED
160 170 180 190 200
DKPLPTSKPR KQYKMAKENR GDDGATERPK KAKEERRMDQ MMPGKTKADA
210 220 230 240 250
ADPAPLPSQE PPRNSTEQQG LASGSSVSFV GASGCPEAYK RLLSSFYCKG
260 270 280 290 300
THGIMSPLAK KKLLAQVSKV EALQCQEEGC RHGAEPQASP AVHLPESPQS
310 320 330 340 350
PKGLTENSRH RLTPQEGLQA PGGSLREEAQ AGPCPAAPIF KGCFYTHPTE
360 370 380 390 400
VLKPVSQHPR DFFSRLKDGV LLGPPGKEGL SVKEPQLVWG GDANRPSAFH
410 420 430 440 450
KGGSRKGILY PKPKACWVSP MAKVPAESPT LPPTFPSSPG LGSKRSLEEE
460 470 480 490 500
GAAHSGKRLR AVSPFLKEAD AKKCGAKPAG SGLVSCLLGP ALGPVPPEAY
510 520 530 540 550
RGTMLHCPLN FTGTPGPLKG QAALPFSPLV IPAFPAHFLA TAGPSPMAAG
560 570 580 590
LMHFPPTSFD SALRHRLCPA SSAWHAPPVT TYAAPHFFHL NTKL
Length:594
Mass (Da):64,074
Last modified:May 29, 2007 - v2
Checksum:i89A494C4560416FF
GO

Sequence cautioni

The sequence AAA36325.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62324 mRNA. Translation: AAA36325.1. Different initiation.
CCDSiCCDS33251.1.
PIRiS27962.
RefSeqiNP_997646.1. NM_212481.2.
UniGeneiHs.920.

Genome annotation databases

EnsembliENST00000357485; ENSP00000350078; ENSG00000196843.
GeneIDi10865.
KEGGihsa:10865.
UCSCiuc002swe.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62324 mRNA. Translation: AAA36325.1. Different initiation.
CCDSiCCDS33251.1.
PIRiS27962.
RefSeqiNP_997646.1. NM_212481.2.
UniGeneiHs.920.

3D structure databases

ProteinModelPortaliQ03989.
SMRiQ03989. Positions 55-161.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116074. 20 interactions.
IntActiQ03989. 2 interactions.
MINTiMINT-2868767.
STRINGi9606.ENSP00000350078.

PTM databases

iPTMnetiQ03989.
PhosphoSiteiQ03989.

Polymorphism and mutation databases

BioMutaiARID5A.
DMDMi148840818.

Proteomic databases

MaxQBiQ03989.
PaxDbiQ03989.
PeptideAtlasiQ03989.
PRIDEiQ03989.

Protocols and materials databases

DNASUi10865.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357485; ENSP00000350078; ENSG00000196843.
GeneIDi10865.
KEGGihsa:10865.
UCSCiuc002swe.4. human.

Organism-specific databases

CTDi10865.
GeneCardsiARID5A.
HGNCiHGNC:17361. ARID5A.
HPAiHPA002860.
HPA023879.
MIMi611583. gene.
neXtProtiNX_Q03989.
PharmGKBiPA134937822.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2744. Eukaryota.
ENOG410Y2AP. LUCA.
GeneTreeiENSGT00840000129864.
HOGENOMiHOG000034050.
HOVERGENiHBG062210.
InParanoidiQ03989.
OMAiGLMHFPP.
OrthoDBiEOG7992PR.
PhylomeDBiQ03989.
TreeFamiTF324725.

Miscellaneous databases

ChiTaRSiARID5A. human.
GenomeRNAii10865.
PROiQ03989.
SOURCEiSearch...

Gene expression databases

BgeeiQ03989.
CleanExiHS_ARID5A.
ExpressionAtlasiQ03989. baseline and differential.
GenevisibleiQ03989. HS.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID_dom.
[Graphical view]
PfamiPF01388. ARID. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Repression by a differentiation-specific factor of the human cytomegalovirus enhancer."
    Huang T.H., Oka T., Asai T., Okada T., Merrills B.W., Gertson P.N., Whitson R.H., Itakura K.
    Nucleic Acids Res. 24:1695-1701(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Foreskin fibroblast.

Entry informationi

Entry nameiARI5A_HUMAN
AccessioniPrimary (citable) accession number: Q03989
Secondary accession number(s): Q6NX37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.