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Protein
Submitted name:

Mosquitocidal toxin

Gene

mtx1

Organism
Lysinibacillus sphaericus (Bacillus sphaericus)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

Names & Taxonomyi

Protein namesi
Submitted name:
Mosquitocidal toxinImported
Gene namesi
Name:mtx1Imported
OrganismiLysinibacillus sphaericus (Bacillus sphaericus)Imported
Taxonomic identifieri1421 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeLysinibacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 870840Sequence analysisPRO_5007697506Add
BLAST

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CB4X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N30-308[»]
2CB6X-ray3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P30-308[»]
2VSAX-ray2.89A30-870[»]
2VSEX-ray2.50A/B30-870[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini334 – 438105Ricin B-type lectinInterPro annotationAdd
BLAST
Domaini475 – 579105Ricin B-type lectinInterPro annotationAdd
BLAST
Domaini617 – 720104Ricin B-type lectinInterPro annotationAdd
BLAST
Domaini762 – 862101Ricin B-type lectinInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

InterProiIPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF14200. RicinB_lectin_2. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 4 hits.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 4 hits.
PROSITEiPS50231. RICIN_B_LECTIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03988-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKKVLKII LAIIIIISCQ LPLNQKTVYA SPNSPKDNTW IQAASLTWLM
60 70 80 90 100
DMSSLLYQLI STRIPSFASP NGLHMREQTI DSNTGQIQID NEHRLLRWDR
110 120 130 140 150
RPPNDIFLNG FIPRVTNQNL SPVEDTHLLN YLRTNSPSIF VSTTRARYNN
160 170 180 190 200
LGLEITPWTP HSANNNIIYR YEIFAPGGID INASFSRNHN PFPNEDEITF
210 220 230 240 250
PGGIRPEFIR STYEYHNGEI VRIWINPNFI NPSTLNDVSG PSNISKVFWH
260 270 280 290 300
ENHSEGNNMD SKGFILDLDY NQDFDMFAPN GEIPNNNLLN NNSLNVIQNS
310 320 330 340 350
EYQIKNKKDR NIVVTLDSDY GGSPVESYKN FGFENQKWNI KYDSKKNAYK
360 370 380 390 400
IYNRETPTLL LSWNSNSSNG EQVIRGYTES GSNNQYWTIE KNVNGFYKFR
410 420 430 440 450
NLSDPSKILD LKDGNTLNKT PLVVSSENSS SSQEWLIEKT NYQTVKDGTY
460 470 480 490 500
QVSSKLNENK VIEQISTNKV HIFSNSDKEN QVWNLIYNPI LKAYKIKSLK
510 520 530 540 550
YPNYSLAWDS NNTRTIVAAT GDYNDQYWLI ERNEDNTYII RNYENRKIVL
560 570 580 590 600
DLSNGSTTDG NGLLGFEFHG GINQRWIIKP FSFNSIQDGI YQFMTVINQD
610 620 630 640 650
LIADLTTNNY TIATKTNNYS SNQKWTVTYN DKKRAYKIRN LQHAHLSLAW
660 670 680 690 700
DSNHSDKIFG ATGDYDDQYW IPILQTDGSF IFRNYKNPNK IFGTNGQPIN
710 720 730 740 750
DIPLKAQDVT GQNNQKWYLR HLNSSNNFTG YFNISSKKNF NKIITMNSNK
760 770 780 790 800
TQAVIFDNIG INNQSWKLKY NDNKNAYQIH ILDNFLYFQG GHNIVATMRN
810 820 830 840 850
VTNDDLRSYW YVEYNFNKDG FIIRNAFDTS YVLDVFQGNF ANNTPIITYQ
860 870
NYLNDNQLWN FIPSLGVEPR
Length:870
Mass (Da):100,577
Last modified:November 1, 1996 - v1
Checksum:iE47FDDEAFD142E7E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60446 Genomic DNA. Translation: AAA22601.1.
AF538928 Genomic DNA. Translation: AAN04906.1.
PIRiB44916. S27514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60446 Genomic DNA. Translation: AAA22601.1.
AF538928 Genomic DNA. Translation: AAN04906.1.
PIRiB44916. S27514.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CB4X-ray2.50A/B/C/D/E/F/G/H/I/J/K/L/M/N30-308[»]
2CB6X-ray3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P30-308[»]
2VSAX-ray2.89A30-870[»]
2VSEX-ray2.50A/B30-870[»]
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiCBM13. Carbohydrate-Binding Module Family 13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR000772. Ricin_B_lectin.
[Graphical view]
PfamiPF14200. RicinB_lectin_2. 1 hit.
[Graphical view]
SMARTiSM00458. RICIN. 4 hits.
[Graphical view]
SUPFAMiSSF50370. SSF50370. 4 hits.
PROSITEiPS50231. RICIN_B_LECTIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequencing, and expression of a gene encoding a 100-kilodalton mosquitocidal toxin from Bacillus sphaericus SSII-1."
    Thanabalu T., Hindley J., Jackson-Yap J., Berry C.
    J. Bacteriol. 173:2776-2785(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: SSII-1Imported.
  2. "Proteolytic processing of the mosquitocidal toxin from Bacillus sphaericus SSII-1."
    Thanabalu T., Hindley J., Berry C.
    J. Bacteriol. 174:5051-5056(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Cloning and expression in Escherichia coli of the mosquitocidal toxin gene from Bacillus sphaericus strain LP1-G."
    Shi R., Cai Q., Yan J., Yuan Z.
    Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LP1-GImported.
  4. "Toxicity of Bacillus sphaericus LP1-G against susceptible and resistant Culex quinquefasciatus and the cloning of the mosquitocidal toxin gene."
    Shi Y.X., Zheng D.S., Yuan Z.M.
    Curr. Microbiol. 47:226-230(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: LP1-GImported.
  5. "Structure of the mosquitocidal toxin from Bacillus sphaericus."
    Reinert D.J., Carpusca I., Aktories K., Schulz G.E.
    J. Mol. Biol. 357:1226-1236(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 30-308.
  6. "Structure and mode of action of a mosquitocidal holotoxin."
    Treiber N., Reinert D.J., Carpusca I., Aktories K., Schulz G.E.
    J. Mol. Biol. 381:150-159(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 30-870.

Entry informationi

Entry nameiQ03988_LYSSH
AccessioniPrimary (citable) accession number: Q03988
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.