Q03986 (ERMD_BACLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
rRNA adenine N-6-methyltransferase
EC=2.1.1.-

Alternative name(s):
Erythromycin resistance protein
Macrolide-lincosamide-streptogramin B resistance protein

Gene names

Name:

ermD

Organism

Bacillus licheniformis

Taxonomic identifier

1402 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in erythromycin resistance.
Catalytic activity	S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine.
Induction	By erythromycin and oleandomycin.
Sequence similarities	Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.

Ontologies

Keywords
Biological process	Antibiotic resistance
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Gene Ontology (GO)
Biological process	response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA (adenine-N6,N6-)-dimethyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 287	287	rRNA adenine N-6-methyltransferase		PRO_0000101669

Sequences

	Sequence		Length	Mass (Da)
	Q03986 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D3227F255A729060	FASTA	287	32,798
	10 20 30 40 50 60 MKKKNHKYRG KKLNRGESPN FSGQHLMHNK KLIEEIVDRA NISIDDTVLE LGAGKGALTT 70 80 90 100 110 120 VLSQKAGKVL AVENDSKFVD ILTRKTAQHS NTKIIHQDIM KIHLPKEKFV VVSNIPYAIT 130 140 150 160 170 180 TPIMKMLLNN PASGFQKGII VMEKGAAKRF TSKFIKNSYV LAWRMWFDIG IVREISKEHF 190 200 210 220 230 240 SPPPKVDSAM VRITRKKDAP LSHKHYIAFR GLAEYALKEP NIPLCVALRG IFTPRQMKHL 250 260 270 280 RKSLKINNEK TVGTLTENQW AVIFNTMTQY VMHHKWPRAN KRKPGEI

References

[1]	"DNA sequence and regulation of ermD, a macrolide-lincosamide-streptogramin B resistance element from Bacillus licheniformis." Gryczan T., Israeli-Reches M., del Bue M., Dubnau D. Mol. Gen. Genet. 194:349-356(1984) [PubMed: 6429477] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M29832 Genomic DNA. Translation: AAA22599.1.
PIR	I39885.
3D structure databases
ProteinModelPortal	Q03986.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR020596. rRNA_Ade_Mease_Trfase_CS. IPR001737. rRNA_Ade_methylase_transferase. IPR020598. rRNA_Ade_methylase_Trfase_N. [Graphical view]
PANTHER	PTHR11727. RRNA_meth_trans. 1 hit.
Pfam	PF00398. RrnaAD. 1 hit. [Graphical view]
SMART	SM00650. rADc. 1 hit. [Graphical view]
PROSITE	PS01131. RRNA_A_DIMETH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERMD_BACLI

Accession

Primary (citable) accession number: Q03986

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	September 21, 2011
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program