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Q03973

- HMO1_YEAST

UniProt

Q03973 - HMO1_YEAST

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Protein

High mobility group protein 1

Gene

HMO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi106 – 17974HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: SGD
  2. double-stranded DNA binding Source: SGD
  3. four-way junction DNA binding Source: SGD

GO - Biological processi

  1. regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
  2. regulation of transcription by chromatin organization Source: SGD
  3. regulation of transcription from RNA polymerase I promoter Source: SGD
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29763-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein 1
Alternative name(s):
High spontaneous mutagenesis protein 2
Gene namesi
Name:HMO1
Synonyms:HSM2
Ordered Locus Names:YDR174W
ORF Names:YD9395.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR174w.
SGDiS000002581. HMO1.

Subcellular locationi

Nucleusnucleolus 3 Publications
Note: Colocalizes with FOB1.

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. cytosol Source: SGD
  3. nucleolus Source: SGD
  4. nucleus Source: SGD
  5. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246High mobility group protein 1PRO_0000048564Add
BLAST

Proteomic databases

MaxQBiQ03973.
PaxDbiQ03973.
PeptideAtlasiQ03973.

Expressioni

Gene expression databases

GenevestigatoriQ03973.

Interactioni

Subunit structurei

Interacts with FPR1. Interacts with an unidentified DNA helicase. Associates with rDNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ELG1Q120502EBI-33047,EBI-32195

Protein-protein interaction databases

BioGridi32227. 284 interactions.
DIPiDIP-1687N.
IntActiQ03973. 50 interactions.
MINTiMINT-8285186.
STRINGi4932.YDR174W.

Structurei

3D structure databases

ProteinModelPortaliQ03973.
SMRiQ03973. Positions 98-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi228 – 24114Poly-LysAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5648.
HOGENOMiHOG000001040.
InParanoidiQ03973.
OMAiPLTMYFA.
OrthoDBiEOG70KH25.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03973-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTDPSVKLK SAKDSLVSSL FELSKAANQT ASSIVDFYNA IGDDEEEKIE
60 70 80 90 100
AFTTLTESLQ TLTSGVNHLH GISSELVNPI DDDKDAIIAA PVKAVRRKIE
110 120 130 140 150
RDPNAPKKPL TVFFAYSAYV RQELREDRQK AGLPPLSSTE ITQEISKKWK
160 170 180 190 200
ELSDNEKEKW KQAYNVELEN YQREKSKYLE AKKNGTLPPA SLENGPTHAP
210 220 230 240
VPIPFSLQHA AEPPVEKRPH DDDGSSEKKK KKKKKDKKKD KSNSSI
Length:246
Mass (Da):27,544
Last modified:November 1, 1996 - v1
Checksum:i3D6DCD56A28B7D77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46727 Genomic DNA. Translation: CAA86679.1.
AY557680 Genomic DNA. Translation: AAS56006.1.
BK006938 Genomic DNA. Translation: DAA12016.1.
PIRiS49770.
RefSeqiNP_010459.1. NM_001180481.1.

Genome annotation databases

EnsemblFungiiYDR174W; YDR174W; YDR174W.
GeneIDi851754.
KEGGisce:YDR174W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46727 Genomic DNA. Translation: CAA86679.1 .
AY557680 Genomic DNA. Translation: AAS56006.1 .
BK006938 Genomic DNA. Translation: DAA12016.1 .
PIRi S49770.
RefSeqi NP_010459.1. NM_001180481.1.

3D structure databases

ProteinModelPortali Q03973.
SMRi Q03973. Positions 98-182.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32227. 284 interactions.
DIPi DIP-1687N.
IntActi Q03973. 50 interactions.
MINTi MINT-8285186.
STRINGi 4932.YDR174W.

Proteomic databases

MaxQBi Q03973.
PaxDbi Q03973.
PeptideAtlasi Q03973.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR174W ; YDR174W ; YDR174W .
GeneIDi 851754.
KEGGi sce:YDR174W.

Organism-specific databases

CYGDi YDR174w.
SGDi S000002581. HMO1.

Phylogenomic databases

eggNOGi COG5648.
HOGENOMi HOG000001040.
InParanoidi Q03973.
OMAi PLTMYFA.
OrthoDBi EOG70KH25.

Enzyme and pathway databases

BioCyci YEAST:G3O-29763-MONOMER.

Miscellaneous databases

NextBioi 969516.

Gene expression databases

Genevestigatori Q03973.

Family and domain databases

Gene3Di 1.10.30.10. 1 hit.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 1 hit.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 1 hit.
PROSITEi PS50118. HMG_BOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Characterization of a high mobility group 1/2 homolog in yeast."
    Lu J., Kobayashi R., Brill S.J.
    J. Biol. Chem. 271:33678-33685(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 14-25; 51-84 AND 163-175, SUBCELLULAR LOCATION, DNA-BINDING.
  5. "Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase."
    Dolinski K.J., Heitman J.
    Genetics 151:935-944(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FPR1.
  6. "HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae."
    Alekseev S.Y., Kovaltsova S.V., Fedorova I.V., Gracheva L.M., Evstukhina T.A., Peshekhonov V.T., Korolev V.G.
    DNA Repair 1:287-297(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system."
    Gadal O., Labarre S., Boschiero C., Thuriaux P.
    EMBO J. 21:5498-5507(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMO1_YEAST
AccessioniPrimary (citable) accession number: Q03973
Secondary accession number(s): D6VSF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 19000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3