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Q03973 (HMO1_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
High mobility group protein 1
Alternative name(s):
High spontaneous mutagenesis protein 2
Gene names
Name:HMO1
Synonyms:HSM2
Ordered Locus Names:YDR174W
ORF Names:YD9395.07
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control. Ref.6 Ref.7

Subunit structure

Interacts with FPR1. Interacts with an unidentified DNA helicase. Associates with rDNA. Ref.5

Subcellular location

Nucleus › nucleolus. Note: Colocalizes with FOB1. Ref.4 Ref.7 Ref.8

Miscellaneous

Present with 19000 molecules/cell in log phase SD medium.

Sequence similarities

Contains 1 HMG box DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246High mobility group protein 1
PRO_0000048564

Regions

DNA binding106 – 17974HMG box Ref.4
Compositional bias228 – 24114Poly-Lys

Sequences

Sequence LengthMass (Da)Tools
Q03973 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 3D6DCD56A28B7D77

FASTA24627,544
        10         20         30         40         50         60 
MTTDPSVKLK SAKDSLVSSL FELSKAANQT ASSIVDFYNA IGDDEEEKIE AFTTLTESLQ 

        70         80         90        100        110        120 
TLTSGVNHLH GISSELVNPI DDDKDAIIAA PVKAVRRKIE RDPNAPKKPL TVFFAYSAYV 

       130        140        150        160        170        180 
RQELREDRQK AGLPPLSSTE ITQEISKKWK ELSDNEKEKW KQAYNVELEN YQREKSKYLE 

       190        200        210        220        230        240 
AKKNGTLPPA SLENGPTHAP VPIPFSLQHA AEPPVEKRPH DDDGSSEKKK KKKKKDKKKD 


KSNSSI

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[4]"Characterization of a high mobility group 1/2 homolog in yeast."
Lu J., Kobayashi R., Brill S.J.
J. Biol. Chem. 271:33678-33685(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 14-25; 51-84 AND 163-175, SUBCELLULAR LOCATION, DNA-BINDING.
[5]"Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase."
Dolinski K.J., Heitman J.
Genetics 151:935-944(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FPR1.
[6]"HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae."
Alekseev S.Y., Kovaltsova S.V., Fedorova I.V., Gracheva L.M., Evstukhina T.A., Peshekhonov V.T., Korolev V.G.
DNA Repair 1:287-297(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system."
Gadal O., Labarre S., Boschiero C., Thuriaux P.
EMBO J. 21:5498-5507(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION.
[8]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[9]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z46727 Genomic DNA. Translation: CAA86679.1.
AY557680 Genomic DNA. Translation: AAS56006.1.
BK006938 Genomic DNA. Translation: DAA12016.1.
PIRS49770.
RefSeqNP_010459.1. NM_001180481.1.

3D structure databases

ProteinModelPortalQ03973.
SMRQ03973. Positions 105-178.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-1687N.
IntActQ03973. 47 interactions.
MINTMINT-407581.
STRING4932.YDR174W.

Proteomic databases

PaxDbQ03973.
PeptideAtlasQ03973.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR174W; YDR174W; YDR174W.
GeneID851754.
KEGGsce:YDR174W.

Organism-specific databases

CYGDYDR174w.
SGDS000002581. HMO1.

Phylogenomic databases

eggNOGCOG5648.
HOGENOMHOG000001040.
OMAFFAYSAY.
OrthoDBEOG40P7HK.

Gene expression databases

GenevestigatorQ03973.
GermOnlineYDR174W. Saccharomyces cerevisiae.

Family and domain databases

Gene3D1.10.30.10. 1 hit.
InterProIPR009071. HMG_box_dom.
[Graphical view]
PfamPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMSSF47095. HMG-box. 1 hit.
PROSITEPS00353. HMG_BOX_1. False negative.
PS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio969516.

Entry information

Entry nameHMO1_YEAST
AccessionPrimary (citable) accession number: Q03973
Secondary accession number(s): D6VSF6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents