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Protein

High mobility group protein 1

Gene

HMO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.2 Publications

Miscellaneous

Present with 19000 molecules/cell in log phase SD medium.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi106 – 179HMG boxPROSITE-ProRule annotationAdd BLAST74

GO - Molecular functioni

  • DNA binding, bending Source: SGD
  • double-stranded DNA binding Source: SGD
  • four-way junction DNA binding Source: SGD

GO - Biological processi

  • chromosome condensation Source: SGD
  • DNA packaging Source: SGD
  • dsDNA loop formation Source: SGD
  • regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
  • regulation of transcription from RNA polymerase I promoter Source: SGD
  • transcriptional start site selection at RNA polymerase II promoter Source: SGD

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-29763-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein 1
Alternative name(s):
High spontaneous mutagenesis protein 2
Gene namesi
Name:HMO1
Synonyms:HSM2
Ordered Locus Names:YDR174W
ORF Names:YD9395.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR174W.
SGDiS000002581. HMO1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: SGD
  • cytosol Source: SGD
  • nucleolus Source: SGD
  • nucleus Source: SGD
  • rDNA heterochromatin Source: SGD
  • small-subunit processome Source: SGD

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000485641 – 246High mobility group protein 1Add BLAST246

Proteomic databases

MaxQBiQ03973.
PRIDEiQ03973.

PTM databases

iPTMnetiQ03973.

Interactioni

Subunit structurei

Interacts with FPR1. Interacts with an unidentified DNA helicase. Associates with rDNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ELG1Q120502EBI-33047,EBI-32195

Protein-protein interaction databases

BioGridi32227. 301 interactors.
DIPiDIP-1687N.
IntActiQ03973. 50 interactors.
MINTiMINT-8285186.
STRINGi4932.YDR174W.

Structurei

3D structure databases

ProteinModelPortaliQ03973.
SMRiQ03973.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi228 – 241Poly-LysAdd BLAST14

Phylogenomic databases

HOGENOMiHOG000001040.
InParanoidiQ03973.
OMAiHVNNITE.
OrthoDBiEOG092C5ER2.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiView protein in InterPro
IPR009071. HMG_box_dom.
PfamiView protein in Pfam
PF00505. HMG_box. 1 hit.
SMARTiView protein in SMART
SM00398. HMG. 1 hit.
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiView protein in PROSITE
PS50118. HMG_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDPSVKLK SAKDSLVSSL FELSKAANQT ASSIVDFYNA IGDDEEEKIE
60 70 80 90 100
AFTTLTESLQ TLTSGVNHLH GISSELVNPI DDDKDAIIAA PVKAVRRKIE
110 120 130 140 150
RDPNAPKKPL TVFFAYSAYV RQELREDRQK AGLPPLSSTE ITQEISKKWK
160 170 180 190 200
ELSDNEKEKW KQAYNVELEN YQREKSKYLE AKKNGTLPPA SLENGPTHAP
210 220 230 240
VPIPFSLQHA AEPPVEKRPH DDDGSSEKKK KKKKKDKKKD KSNSSI
Length:246
Mass (Da):27,544
Last modified:November 1, 1996 - v1
Checksum:i3D6DCD56A28B7D77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46727 Genomic DNA. Translation: CAA86679.1.
AY557680 Genomic DNA. Translation: AAS56006.1.
BK006938 Genomic DNA. Translation: DAA12016.1.
PIRiS49770.
RefSeqiNP_010459.1. NM_001180481.1.

Genome annotation databases

EnsemblFungiiYDR174W; YDR174W; YDR174W.
GeneIDi851754.
KEGGisce:YDR174W.

Similar proteinsi

Entry informationi

Entry nameiHMO1_YEAST
AccessioniPrimary (citable) accession number: Q03973
Secondary accession number(s): D6VSF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names