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Q03973

- HMO1_YEAST

UniProt

Q03973 - HMO1_YEAST

Protein

High mobility group protein 1

Gene

HMO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi106 – 17974HMG boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding, bending Source: SGD
    2. double-stranded DNA binding Source: SGD
    3. four-way junction DNA binding Source: SGD
    4. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
    2. regulation of transcription by chromatin organization Source: SGD
    3. regulation of transcription from RNA polymerase I promoter Source: SGD
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29763-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group protein 1
    Alternative name(s):
    High spontaneous mutagenesis protein 2
    Gene namesi
    Name:HMO1
    Synonyms:HSM2
    Ordered Locus Names:YDR174W
    ORF Names:YD9395.07
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR174w.
    SGDiS000002581. HMO1.

    Subcellular locationi

    Nucleusnucleolus 3 Publications
    Note: Colocalizes with FOB1.

    GO - Cellular componenti

    1. cytoplasm Source: SGD
    2. cytosol Source: SGD
    3. nucleolus Source: SGD
    4. nucleus Source: SGD
    5. small-subunit processome Source: SGD

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246High mobility group protein 1PRO_0000048564Add
    BLAST

    Proteomic databases

    MaxQBiQ03973.
    PaxDbiQ03973.
    PeptideAtlasiQ03973.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03973.

    Interactioni

    Subunit structurei

    Interacts with FPR1. Interacts with an unidentified DNA helicase. Associates with rDNA.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ELG1Q120502EBI-33047,EBI-32195

    Protein-protein interaction databases

    BioGridi32227. 283 interactions.
    DIPiDIP-1687N.
    IntActiQ03973. 50 interactions.
    MINTiMINT-8285186.
    STRINGi4932.YDR174W.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03973.
    SMRiQ03973. Positions 97-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi228 – 24114Poly-LysAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5648.
    HOGENOMiHOG000001040.
    OMAiPLTMYFA.
    OrthoDBiEOG70KH25.

    Family and domain databases

    Gene3Di1.10.30.10. 1 hit.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 1 hit.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 1 hit.
    PROSITEiPS50118. HMG_BOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03973-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTDPSVKLK SAKDSLVSSL FELSKAANQT ASSIVDFYNA IGDDEEEKIE    50
    AFTTLTESLQ TLTSGVNHLH GISSELVNPI DDDKDAIIAA PVKAVRRKIE 100
    RDPNAPKKPL TVFFAYSAYV RQELREDRQK AGLPPLSSTE ITQEISKKWK 150
    ELSDNEKEKW KQAYNVELEN YQREKSKYLE AKKNGTLPPA SLENGPTHAP 200
    VPIPFSLQHA AEPPVEKRPH DDDGSSEKKK KKKKKDKKKD KSNSSI 246
    Length:246
    Mass (Da):27,544
    Last modified:November 1, 1996 - v1
    Checksum:i3D6DCD56A28B7D77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46727 Genomic DNA. Translation: CAA86679.1.
    AY557680 Genomic DNA. Translation: AAS56006.1.
    BK006938 Genomic DNA. Translation: DAA12016.1.
    PIRiS49770.
    RefSeqiNP_010459.1. NM_001180481.1.

    Genome annotation databases

    EnsemblFungiiYDR174W; YDR174W; YDR174W.
    GeneIDi851754.
    KEGGisce:YDR174W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z46727 Genomic DNA. Translation: CAA86679.1 .
    AY557680 Genomic DNA. Translation: AAS56006.1 .
    BK006938 Genomic DNA. Translation: DAA12016.1 .
    PIRi S49770.
    RefSeqi NP_010459.1. NM_001180481.1.

    3D structure databases

    ProteinModelPortali Q03973.
    SMRi Q03973. Positions 97-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32227. 283 interactions.
    DIPi DIP-1687N.
    IntActi Q03973. 50 interactions.
    MINTi MINT-8285186.
    STRINGi 4932.YDR174W.

    Proteomic databases

    MaxQBi Q03973.
    PaxDbi Q03973.
    PeptideAtlasi Q03973.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR174W ; YDR174W ; YDR174W .
    GeneIDi 851754.
    KEGGi sce:YDR174W.

    Organism-specific databases

    CYGDi YDR174w.
    SGDi S000002581. HMO1.

    Phylogenomic databases

    eggNOGi COG5648.
    HOGENOMi HOG000001040.
    OMAi PLTMYFA.
    OrthoDBi EOG70KH25.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29763-MONOMER.

    Miscellaneous databases

    NextBioi 969516.

    Gene expression databases

    Genevestigatori Q03973.

    Family and domain databases

    Gene3Di 1.10.30.10. 1 hit.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 1 hit.
    PROSITEi PS50118. HMG_BOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Characterization of a high mobility group 1/2 homolog in yeast."
      Lu J., Kobayashi R., Brill S.J.
      J. Biol. Chem. 271:33678-33685(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 14-25; 51-84 AND 163-175, SUBCELLULAR LOCATION, DNA-BINDING.
    5. "Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase."
      Dolinski K.J., Heitman J.
      Genetics 151:935-944(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FPR1.
    6. "HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae."
      Alekseev S.Y., Kovaltsova S.V., Fedorova I.V., Gracheva L.M., Evstukhina T.A., Peshekhonov V.T., Korolev V.G.
      DNA Repair 1:287-297(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system."
      Gadal O., Labarre S., Boschiero C., Thuriaux P.
      EMBO J. 21:5498-5507(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiHMO1_YEAST
    AccessioniPrimary (citable) accession number: Q03973
    Secondary accession number(s): D6VSF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 19000 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3