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Protein

High mobility group protein 1

Gene

HMO1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that is probably part of the rDNA transcription apparatus. Acts synergetically with the RPA49 subunit of RNA polymerase I during rDNA transcription. May participate in mutagenesis control.2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi106 – 17974HMG boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding, bending Source: SGD
  2. double-stranded DNA binding Source: SGD
  3. four-way junction DNA binding Source: SGD

GO - Biological processi

  1. DNA packaging Source: SGD
  2. dsDNA loop formation Source: SGD
  3. regulation of ribosomal protein gene transcription from RNA polymerase II promoter Source: SGD
  4. regulation of transcription from RNA polymerase I promoter Source: SGD
  5. transcriptional start site selection at RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-29763-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein 1
Alternative name(s):
High spontaneous mutagenesis protein 2
Gene namesi
Name:HMO1
Synonyms:HSM2
Ordered Locus Names:YDR174W
ORF Names:YD9395.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311 Componenti: Chromosome IV

Organism-specific databases

CYGDiYDR174w.
EuPathDBiFungiDB:YDR174W.
SGDiS000002581. HMO1.

Subcellular locationi

  1. Nucleusnucleolus 3 Publications

  2. Note: Colocalizes with FOB1.

GO - Cellular componenti

  1. cytoplasm Source: SGD
  2. cytosol Source: SGD
  3. nucleolus Source: SGD
  4. nucleus Source: SGD
  5. rDNA heterochromatin Source: SGD
  6. small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246High mobility group protein 1PRO_0000048564Add
BLAST

Proteomic databases

MaxQBiQ03973.
PaxDbiQ03973.
PeptideAtlasiQ03973.

Expressioni

Gene expression databases

GenevestigatoriQ03973.

Interactioni

Subunit structurei

Interacts with FPR1. Interacts with an unidentified DNA helicase. Associates with rDNA.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ELG1Q120502EBI-33047,EBI-32195

Protein-protein interaction databases

BioGridi32227. 290 interactions.
DIPiDIP-1687N.
IntActiQ03973. 50 interactions.
MINTiMINT-8285186.
STRINGi4932.YDR174W.

Structurei

3D structure databases

ProteinModelPortaliQ03973.
SMRiQ03973. Positions 98-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi228 – 24114Poly-LysAdd
BLAST

Sequence similaritiesi

Contains 1 HMG box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5648.
HOGENOMiHOG000001040.
InParanoidiQ03973.
OMAiPLTMYFA.
OrthoDBiEOG70KH25.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03973-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTDPSVKLK SAKDSLVSSL FELSKAANQT ASSIVDFYNA IGDDEEEKIE
60 70 80 90 100
AFTTLTESLQ TLTSGVNHLH GISSELVNPI DDDKDAIIAA PVKAVRRKIE
110 120 130 140 150
RDPNAPKKPL TVFFAYSAYV RQELREDRQK AGLPPLSSTE ITQEISKKWK
160 170 180 190 200
ELSDNEKEKW KQAYNVELEN YQREKSKYLE AKKNGTLPPA SLENGPTHAP
210 220 230 240
VPIPFSLQHA AEPPVEKRPH DDDGSSEKKK KKKKKDKKKD KSNSSI
Length:246
Mass (Da):27,544
Last modified:November 1, 1996 - v1
Checksum:i3D6DCD56A28B7D77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46727 Genomic DNA. Translation: CAA86679.1.
AY557680 Genomic DNA. Translation: AAS56006.1.
BK006938 Genomic DNA. Translation: DAA12016.1.
PIRiS49770.
RefSeqiNP_010459.1. NM_001180481.1.

Genome annotation databases

EnsemblFungiiYDR174W; YDR174W; YDR174W.
GeneIDi851754.
KEGGisce:YDR174W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z46727 Genomic DNA. Translation: CAA86679.1.
AY557680 Genomic DNA. Translation: AAS56006.1.
BK006938 Genomic DNA. Translation: DAA12016.1.
PIRiS49770.
RefSeqiNP_010459.1. NM_001180481.1.

3D structure databases

ProteinModelPortaliQ03973.
SMRiQ03973. Positions 98-182.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32227. 290 interactions.
DIPiDIP-1687N.
IntActiQ03973. 50 interactions.
MINTiMINT-8285186.
STRINGi4932.YDR174W.

Proteomic databases

MaxQBiQ03973.
PaxDbiQ03973.
PeptideAtlasiQ03973.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR174W; YDR174W; YDR174W.
GeneIDi851754.
KEGGisce:YDR174W.

Organism-specific databases

CYGDiYDR174w.
EuPathDBiFungiDB:YDR174W.
SGDiS000002581. HMO1.

Phylogenomic databases

eggNOGiCOG5648.
HOGENOMiHOG000001040.
InParanoidiQ03973.
OMAiPLTMYFA.
OrthoDBiEOG70KH25.

Enzyme and pathway databases

BioCyciYEAST:G3O-29763-MONOMER.

Miscellaneous databases

NextBioi969516.
PROiQ03973.

Gene expression databases

GenevestigatoriQ03973.

Family and domain databases

Gene3Di1.10.30.10. 1 hit.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 1 hit.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 1 hit.
PROSITEiPS50118. HMG_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Characterization of a high mobility group 1/2 homolog in yeast."
    Lu J., Kobayashi R., Brill S.J.
    J. Biol. Chem. 271:33678-33685(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 14-25; 51-84 AND 163-175, SUBCELLULAR LOCATION, DNA-BINDING.
  5. "Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase."
    Dolinski K.J., Heitman J.
    Genetics 151:935-944(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FPR1.
  6. "HSM2 (HMO1) gene participates in mutagenesis control in yeast Saccharomyces cerevisiae."
    Alekseev S.Y., Kovaltsova S.V., Fedorova I.V., Gracheva L.M., Evstukhina T.A., Peshekhonov V.T., Korolev V.G.
    DNA Repair 1:287-297(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system."
    Gadal O., Labarre S., Boschiero C., Thuriaux P.
    EMBO J. 21:5498-5507(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION.
  8. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  9. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiHMO1_YEAST
AccessioniPrimary (citable) accession number: Q03973
Secondary accession number(s): D6VSF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: November 1, 1996
Last modified: April 29, 2015
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 19000 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.