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Q03966

- LAC1_CRYPA

UniProt

Q03966 - LAC1_CRYPA

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Protein
Laccase
Gene
LAC-1
Organism
Cryphonectria parasitica (Chesnut blight fungus) (Endothia parasitica)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261Copper 1; type 2 By similarity
Metal bindingi128 – 1281Copper 2; type 3 By similarity
Metal bindingi171 – 1711Copper 2; type 3 By similarity
Metal bindingi173 – 1731Copper 3; type 3 By similarity
Metal bindingi463 – 4631Copper 4; type 1 By similarity
Metal bindingi466 – 4661Copper 1; type 2 By similarity
Metal bindingi468 – 4681Copper 3; type 3 By similarity
Metal bindingi533 – 5331Copper 3; type 3 By similarity
Metal bindingi534 – 5341Copper 4; type 1 By similarity
Metal bindingi535 – 5351Copper 2; type 3 By similarity
Metal bindingi539 – 5391Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase
Diphenol oxidase
Urishiol oxidase
Gene namesi
Name:LAC-1
OrganismiCryphonectria parasitica (Chesnut blight fungus) (Endothia parasitica)
Taxonomic identifieri5116 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeDiaporthalesCryphonectriaceaeCryphonectria-Endothia complexCryphonectria

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed prediction
Add
BLAST
Chaini21 – 591571Laccase
PRO_0000002920Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi121 – 1211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi234 – 2341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi242 – 2421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi407 – 4071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi425 – 4251N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ03966.
SMRiQ03966. Positions 33-591.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 189124Plastocyanin-like 1
Add
BLAST
Domaini198 – 356159Plastocyanin-like 2
Add
BLAST
Domaini416 – 551136Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03966-1 [UniParc]FASTAAdd to Basket

« Hide

MPSFFRALFS GLIASQLSWA APSLLHPLEP RQQPNCNTAS NRACWISGSY    50
DITTDYEVKT PLTGVVRQYD LTLTQAENWL GPDGVVKEDV MLVNGNILGP 100
VIHAQWGDTI SVTVTNNLKY NGTTIHWHGI RQLNTNLQDG VNGITECPIP 150
PNGGSKTYTF IAHQYGTSWY HSHFSAQYGN GIVGAIQIDG PASLPYDIDL 200
GPLVLSDYYY KTADELVVYT QSNAPPASDN VLFNGTNINP ANTTQGQYKT 250
ITLTPGKRHR LRIINTSVEN NFQVSIVGHS MTVIESDFVP VDSFTTDSLF 300
VGIGQRYDVT IDASQATDNY WMNVTFGGGG FCGKSNNPYP AAIIHYNGAS 350
NSHPTNKGVA PADHECLDLL NLVPVVPRSI PTSGFVAASD NTLDVQLSTT 400
TRKWTINGST LDVDWGHPIT QYVINKSTAW PSTDNVWLVE EANQWAYWLI 450
ENDPTATGNA LPHPIHLHGH DFVVLGRSPN VSPTAQTPYT FTSSDVSSLN 500
GNNPIRRDVV MLPPKGWLLI AFQTTNPGAW LMHCHIAWHV SAGLGNTFLE 550
QPSAFVAGLN TNDVNQLNSQ CKSWNAYYPS KDIFKQDDSG V 591
Length:591
Mass (Da):64,696
Last modified:November 1, 1996 - v1
Checksum:iB2F44CB2AAD77701
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73257 Genomic DNA. Translation: AAA33105.1.
S38903 Genomic DNA. Translation: AAA09235.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73257 Genomic DNA. Translation: AAA33105.1 .
S38903 Genomic DNA. Translation: AAA09235.1 .

3D structure databases

ProteinModelPortali Q03966.
SMRi Q03966. Positions 33-591.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular analysis of the laccase gene from the chestnut blight fungus and selective suppression of its expression in an isogenic hypovirulent strain."
    Choi G.H., Larson T.G., Nuss D.L.
    Mol. Plant Microbe Interact. 5:119-128(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiLAC1_CRYPA
AccessioniPrimary (citable) accession number: Q03966
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 16, 2013
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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