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Q03966

- LAC1_CRYPA

UniProt

Q03966 - LAC1_CRYPA

Protein

Laccase

Gene

LAC-1

Organism
Cryphonectria parasitica (Chesnut blight fungus) (Endothia parasitica)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi126 – 1261Copper 1; type 2By similarity
    Metal bindingi128 – 1281Copper 2; type 3By similarity
    Metal bindingi171 – 1711Copper 2; type 3By similarity
    Metal bindingi173 – 1731Copper 3; type 3By similarity
    Metal bindingi463 – 4631Copper 4; type 1By similarity
    Metal bindingi466 – 4661Copper 1; type 2By similarity
    Metal bindingi468 – 4681Copper 3; type 3By similarity
    Metal bindingi533 – 5331Copper 3; type 3By similarity
    Metal bindingi534 – 5341Copper 4; type 1By similarity
    Metal bindingi535 – 5351Copper 2; type 3By similarity
    Metal bindingi539 – 5391Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase
    Diphenol oxidase
    Urishiol oxidase
    Gene namesi
    Name:LAC-1
    OrganismiCryphonectria parasitica (Chesnut blight fungus) (Endothia parasitica)
    Taxonomic identifieri5116 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeDiaporthalesCryphonectriaceaeCryphonectria-Endothia complexCryphonectria

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 591571LaccasePRO_0000002920Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi234 – 2341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi242 – 2421N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi425 – 4251N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ03966.
    SMRiQ03966. Positions 33-591.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini66 – 189124Plastocyanin-like 1Add
    BLAST
    Domaini198 – 356159Plastocyanin-like 2Add
    BLAST
    Domaini416 – 551136Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q03966-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSFFRALFS GLIASQLSWA APSLLHPLEP RQQPNCNTAS NRACWISGSY    50
    DITTDYEVKT PLTGVVRQYD LTLTQAENWL GPDGVVKEDV MLVNGNILGP 100
    VIHAQWGDTI SVTVTNNLKY NGTTIHWHGI RQLNTNLQDG VNGITECPIP 150
    PNGGSKTYTF IAHQYGTSWY HSHFSAQYGN GIVGAIQIDG PASLPYDIDL 200
    GPLVLSDYYY KTADELVVYT QSNAPPASDN VLFNGTNINP ANTTQGQYKT 250
    ITLTPGKRHR LRIINTSVEN NFQVSIVGHS MTVIESDFVP VDSFTTDSLF 300
    VGIGQRYDVT IDASQATDNY WMNVTFGGGG FCGKSNNPYP AAIIHYNGAS 350
    NSHPTNKGVA PADHECLDLL NLVPVVPRSI PTSGFVAASD NTLDVQLSTT 400
    TRKWTINGST LDVDWGHPIT QYVINKSTAW PSTDNVWLVE EANQWAYWLI 450
    ENDPTATGNA LPHPIHLHGH DFVVLGRSPN VSPTAQTPYT FTSSDVSSLN 500
    GNNPIRRDVV MLPPKGWLLI AFQTTNPGAW LMHCHIAWHV SAGLGNTFLE 550
    QPSAFVAGLN TNDVNQLNSQ CKSWNAYYPS KDIFKQDDSG V 591
    Length:591
    Mass (Da):64,696
    Last modified:November 1, 1996 - v1
    Checksum:iB2F44CB2AAD77701
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73257 Genomic DNA. Translation: AAA33105.1.
    S38903 Genomic DNA. Translation: AAA09235.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73257 Genomic DNA. Translation: AAA33105.1 .
    S38903 Genomic DNA. Translation: AAA09235.1 .

    3D structure databases

    ProteinModelPortali Q03966.
    SMRi Q03966. Positions 33-591.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular analysis of the laccase gene from the chestnut blight fungus and selective suppression of its expression in an isogenic hypovirulent strain."
      Choi G.H., Larson T.G., Nuss D.L.
      Mol. Plant Microbe Interact. 5:119-128(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiLAC1_CRYPA
    AccessioniPrimary (citable) accession number: Q03966
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3