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Q03964

- YD17A_YEAST

UniProt

Q03964 - YD17A_YEAST

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Protein
Transposon Ty1-DR2 Gag polyprotein
Gene
TY1A-DR2, YDR170W-A, YD9395.02
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Capsid protein (CA) is the structural component of the virus-like particle (VLP), forming the shell that encapsulates the retrotransposons dimeric RNA genome. The particles are assembled from trimer-clustered units and there are holes in the capsid shells that allow for the diffusion of macromolecules. CA has also nucleocapsid-like chaperone activity, promoting primer tRNA(i)-Met annealing to the multipartite primer-binding site (PBS), dimerization of Ty1 RNA and initiation of reverse transcription By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei401 – 4022Cleavage; by Ty1 protease By similarity

GO - Molecular functioni

  1. RNA binding Source: SGD

GO - Biological processi

  1. transposition, RNA-mediated Source: SGD
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transposon Ty1-DR2 Gag polyprotein
Alternative name(s):
Gag-p49
Transposon Ty1 protein A
Short name:
TY1A
Short name:
TYA
p58
Cleaved into the following 2 chains:
Capsid protein
Short name:
CA
Alternative name(s):
Gag-p45
p54
Gene namesi
Name:TY1A-DR2
Ordered Locus Names:YDR170W-A
ORF Names:YD9395.02
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IV

Organism-specific databases

CYGDiYDR170w-a.
SGDiS000007227. YDR170W-A.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. retrotransposon nucleocapsid Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 440440Transposon Ty1-DR2 Gag polyprotein
PRO_0000279040Add
BLAST
Chaini1 – 401401Capsid protein By similarity
PRO_0000279041Add
BLAST
Peptidei402 – 44039Gag-p4 By similarity
PRO_0000279042Add
BLAST

Proteomic databases

MaxQBiQ03964.

Expressioni

Gene expression databases

GenevestigatoriQ03964.

Interactioni

Subunit structurei

Homotrimer By similarity.

Protein-protein interaction databases

BioGridi32223. 10 interactions.
DIPiDIP-8799N.
IntActiQ03964. 2 interactions.
MINTiMINT-680391.
STRINGi4932.YDR170W-A.

Structurei

3D structure databases

ProteinModelPortaliQ03964.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni299 – 401103RNA-binding By similarity
Add
BLAST

Domaini

The C-terminal RNA-binding region of CA is sufficient for all its nucleocapsid-like chaperone activities By similarity.

Phylogenomic databases

GeneTreeiENSGT00710000106943.
HOGENOMiHOG000000740.
OrthoDBiEOG7XPZG1.

Family and domain databases

InterProiIPR015820. Retrotransposon_Ty1A_N.
[Graphical view]
PfamiPF01021. TYA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03964-1 [UniParc]FASTAAdd to Basket

« Hide

MESQQLSQHS PISHGSACAS VTSKEVQTTQ DPLDISASKT EECEKVFTQA    50
NSQQPTTPPS AAVPENHHHA SPQAAQVPLP QNGPYPQQRM MTPQQANISG 100
WPVYGHPSLM PYPPYQMSPM YAPPGAQSQF TQYPQYVGTH LNTPSPESGN 150
SFPDSSSAKS NMTSTNQHVR PPPILTSPND FLNWVKIYIK FLQNSNLGDI 200
IPTATRKAVR QMTDDELTFL CHTFQLFALS QFLPTWVKDI LSVDYTDIMK 250
ILSKSINKMQ SDTQEVNDIT TLANLHYNGS TPADAFEAEV TNILDRLKNN 300
GIPINNKVAC QFIMRGLSGE YKFLRYARHR YIHMTVADLF SDIHSMYEEQ 350
QESKRNKSTY RRSPSDEKKD SRTYTNTTKP KSITRNSQKP NNSQSRTARA 400
HNVSTSNNFP GPDNDLIRGS TTEPIQLKNK HDLHLRPGTY 440
Length:440
Mass (Da):49,445
Last modified:November 1, 1996 - v1
Checksum:i5E10CEE8878CD80E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46727 Genomic DNA. Translation: CAA86697.1.
BK006938 Genomic DNA. Translation: DAA12012.1.
PIRiS49765.
RefSeqiNP_010455.1. NM_001184320.1.

Genome annotation databases

EnsemblFungiiYDR170W-A; YDR170W-A; YDR170W-A.
GeneIDi851750.
KEGGisce:YDR170W-A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z46727 Genomic DNA. Translation: CAA86697.1 .
BK006938 Genomic DNA. Translation: DAA12012.1 .
PIRi S49765.
RefSeqi NP_010455.1. NM_001184320.1.

3D structure databases

ProteinModelPortali Q03964.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 32223. 10 interactions.
DIPi DIP-8799N.
IntActi Q03964. 2 interactions.
MINTi MINT-680391.
STRINGi 4932.YDR170W-A.

Proteomic databases

MaxQBi Q03964.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YDR170W-A ; YDR170W-A ; YDR170W-A .
GeneIDi 851750.
KEGGi sce:YDR170W-A.

Organism-specific databases

CYGDi YDR170w-a.
SGDi S000007227. YDR170W-A.

Phylogenomic databases

GeneTreei ENSGT00710000106943.
HOGENOMi HOG000000740.
OrthoDBi EOG7XPZG1.

Miscellaneous databases

NextBioi 969504.

Gene expression databases

Genevestigatori Q03964.

Family and domain databases

InterProi IPR015820. Retrotransposon_Ty1A_N.
[Graphical view ]
Pfami PF01021. TYA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiYD17A_YEAST
AccessioniPrimary (citable) accession number: Q03964
Secondary accession number(s): D6VSF2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Retrotransposons are mobile genetic entities that are able to replicate via an RNA intermediate and a reverse transcription step. In contrast to retroviruses, retrotransposons are non-infectious, lack an envelope and remain intracellular. Ty1 retrotransposons belong to the copia elements (pseudoviridae).

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

External Data

Dasty 3

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