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Protein

Prefoldin subunit 6

Gene

Pfdn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 6
Alternative name(s):
Protein Ke2
Gene namesi
Name:Pfdn6
Synonyms:H2-Ke2, Pfd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95908. Pfdn6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001248512 – 127Prefoldin subunit 6Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei66N6-acetyllysine; alternateBy similarity1
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ03958.
PaxDbiQ03958.
PeptideAtlasiQ03958.
PRIDEiQ03958.
TopDownProteomicsiQ03958.

PTM databases

iPTMnetiQ03958.
PhosphoSitePlusiQ03958.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024309.
CleanExiMM_H2-KE2.
ExpressionAtlasiQ03958. baseline and differential.
GenevisibleiQ03958. MM.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ03958. 1 interactor.
MINTiMINT-4107274.
STRINGi10090.ENSMUSP00000025163.

Structurei

3D structure databases

ProteinModelPortaliQ03958.
SMRiQ03958.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG3478. Eukaryota.
COG1382. LUCA.
GeneTreeiENSGT00390000010512.
HOGENOMiHOG000196242.
HOVERGENiHBG000199.
InParanoidiQ03958.
KOiK04798.
OMAiIYKLTGP.
OrthoDBiEOG091G105E.
PhylomeDBiQ03958.
TreeFamiTF315166.

Family and domain databases

InterProiView protein in InterPro
IPR002777. PFD_beta-like.
PfamiView protein in Pfam
PF01920. Prefoldin_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL
60 70 80 90 100
DGSNVVFKLL GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ
110 120
SEQQRETLAQ LQQEFQRAQA AKAPGKA
Length:127
Mass (Da):14,455
Last modified:October 1, 1996 - v1
Checksum:i7B1EB0ADB312A9B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65255 mRNA. Translation: AAA39368.1.
M65256 Genomic DNA. Translation: AAA39369.1.
AF100956 Genomic DNA. Translation: AAC69895.1.
AK076015 mRNA. Translation: BAC36121.1.
BC022974 mRNA. Translation: AAH22974.1.
CCDSiCCDS28636.1.
PIRiI53651.
RefSeqiNP_001172111.1. NM_001185182.1.
NP_034515.1. NM_010385.2.
UniGeneiMm.2948.

Genome annotation databases

EnsembliENSMUST00000025163; ENSMUSP00000025163; ENSMUSG00000024309.
ENSMUST00000174048; ENSMUSP00000133656; ENSMUSG00000024309.
ENSMUST00000179418; ENSMUSP00000137072; ENSMUSG00000024309.
GeneIDi14976.
KEGGimmu:14976.
UCSCiuc008cah.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPFD6_MOUSE
AccessioniPrimary (citable) accession number: Q03958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 30, 2017
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families