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Protein

Prefoldin subunit 6

Gene

Pfdn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 6
Alternative name(s):
Protein Ke2
Gene namesi
Name:Pfdn6
Synonyms:H2-Ke2, Pfd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95908 Pfdn6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001248512 – 127Prefoldin subunit 6Add BLAST126

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei21N6-acetyllysineBy similarity1
Modified residuei66N6-acetyllysine; alternateBy similarity1
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki66Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ03958
PaxDbiQ03958
PeptideAtlasiQ03958
PRIDEiQ03958
TopDownProteomicsiQ03958

PTM databases

iPTMnetiQ03958
PhosphoSitePlusiQ03958

Expressioni

Gene expression databases

BgeeiENSMUSG00000024309
CleanExiMM_H2-KE2
ExpressionAtlasiQ03958 baseline and differential
GenevisibleiQ03958 MM

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ03958, 1 interactor
MINTiQ03958
STRINGi10090.ENSMUSP00000025163

Structurei

3D structure databases

ProteinModelPortaliQ03958
SMRiQ03958
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG3478 Eukaryota
COG1382 LUCA
GeneTreeiENSGT00390000010512
HOGENOMiHOG000196242
HOVERGENiHBG000199
InParanoidiQ03958
KOiK04798
OMAiIYKLTGP
OrthoDBiEOG091G105E
PhylomeDBiQ03958
TreeFamiTF315166

Family and domain databases

Gene3Di1.10.287.370, 1 hit
InterProiView protein in InterPro
IPR002777 PFD_beta-like
IPR009053 Prefoldin
PfamiView protein in Pfam
PF01920 Prefoldin_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL
60 70 80 90 100
DGSNVVFKLL GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ
110 120
SEQQRETLAQ LQQEFQRAQA AKAPGKA
Length:127
Mass (Da):14,455
Last modified:October 1, 1996 - v1
Checksum:i7B1EB0ADB312A9B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65255 mRNA Translation: AAA39368.1
M65256 Genomic DNA Translation: AAA39369.1
AF100956 Genomic DNA Translation: AAC69895.1
AK076015 mRNA Translation: BAC36121.1
BC022974 mRNA Translation: AAH22974.1
CCDSiCCDS28636.1
PIRiI53651
RefSeqiNP_001172111.1, NM_001185182.1
NP_034515.1, NM_010385.2
UniGeneiMm.2948

Genome annotation databases

EnsembliENSMUST00000025163; ENSMUSP00000025163; ENSMUSG00000024309
ENSMUST00000174048; ENSMUSP00000133656; ENSMUSG00000024309
ENSMUST00000179418; ENSMUSP00000137072; ENSMUSG00000024309
GeneIDi14976
KEGGimmu:14976
UCSCiuc008cah.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPFD6_MOUSE
AccessioniPrimary (citable) accession number: Q03958
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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