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Protein

Prefoldin subunit 6

Gene

Pfdn6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Prefoldin subunit 6
Alternative name(s):
Protein Ke2
Gene namesi
Name:Pfdn6
Synonyms:H2-Ke2, Pfd6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:95908. Pfdn6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 127126Prefoldin subunit 6PRO_0000124851Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei21 – 211N6-acetyllysineBy similarity
Modified residuei66 – 661N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ03958.
PaxDbiQ03958.
PRIDEiQ03958.
TopDownProteomicsiQ03958.

PTM databases

iPTMnetiQ03958.
PhosphoSiteiQ03958.

Expressioni

Gene expression databases

BgeeiQ03958.
CleanExiMM_H2-KE2.
ExpressionAtlasiQ03958. baseline and differential.
GenevisibleiQ03958. MM.

Interactioni

Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ03958. 1 interaction.
MINTiMINT-4107274.
STRINGi10090.ENSMUSP00000025163.

Structurei

3D structure databases

ProteinModelPortaliQ03958.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prefoldin subunit beta family.Curated

Phylogenomic databases

eggNOGiKOG3478. Eukaryota.
COG1382. LUCA.
HOGENOMiHOG000196242.
HOVERGENiHBG000199.
InParanoidiQ03958.
KOiK04798.
OMAiTNTVYKL.
OrthoDBiEOG7RZ5SG.
PhylomeDBiQ03958.
TreeFamiTF315166.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q03958-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELIQKKLQ GEVEKYQQLQ KDLSKSMSGR QKLEAQLTEN NIVKEELALL
60 70 80 90 100
DGSNVVFKLL GPVLVKQELG EARATVGKRL DYITAEIKRY ESQLRDLERQ
110 120
SEQQRETLAQ LQQEFQRAQA AKAPGKA
Length:127
Mass (Da):14,455
Last modified:October 1, 1996 - v1
Checksum:i7B1EB0ADB312A9B6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65255 mRNA. Translation: AAA39368.1.
M65256 Genomic DNA. Translation: AAA39369.1.
AF100956 Genomic DNA. Translation: AAC69895.1.
AK076015 mRNA. Translation: BAC36121.1.
BC022974 mRNA. Translation: AAH22974.1.
CCDSiCCDS28636.1.
PIRiI53651.
RefSeqiNP_001172111.1. NM_001185182.1.
NP_034515.1. NM_010385.2.
UniGeneiMm.2948.

Genome annotation databases

EnsembliENSMUST00000025163; ENSMUSP00000025163; ENSMUSG00000024309.
ENSMUST00000174048; ENSMUSP00000133656; ENSMUSG00000024309.
ENSMUST00000179418; ENSMUSP00000137072; ENSMUSG00000024309.
GeneIDi14976.
KEGGimmu:14976.
UCSCiuc008cah.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65255 mRNA. Translation: AAA39368.1.
M65256 Genomic DNA. Translation: AAA39369.1.
AF100956 Genomic DNA. Translation: AAC69895.1.
AK076015 mRNA. Translation: BAC36121.1.
BC022974 mRNA. Translation: AAH22974.1.
CCDSiCCDS28636.1.
PIRiI53651.
RefSeqiNP_001172111.1. NM_001185182.1.
NP_034515.1. NM_010385.2.
UniGeneiMm.2948.

3D structure databases

ProteinModelPortaliQ03958.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ03958. 1 interaction.
MINTiMINT-4107274.
STRINGi10090.ENSMUSP00000025163.

PTM databases

iPTMnetiQ03958.
PhosphoSiteiQ03958.

Proteomic databases

EPDiQ03958.
PaxDbiQ03958.
PRIDEiQ03958.
TopDownProteomicsiQ03958.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025163; ENSMUSP00000025163; ENSMUSG00000024309.
ENSMUST00000174048; ENSMUSP00000133656; ENSMUSG00000024309.
ENSMUST00000179418; ENSMUSP00000137072; ENSMUSG00000024309.
GeneIDi14976.
KEGGimmu:14976.
UCSCiuc008cah.1. mouse.

Organism-specific databases

CTDi10471.
MGIiMGI:95908. Pfdn6.

Phylogenomic databases

eggNOGiKOG3478. Eukaryota.
COG1382. LUCA.
HOGENOMiHOG000196242.
HOVERGENiHBG000199.
InParanoidiQ03958.
KOiK04798.
OMAiTNTVYKL.
OrthoDBiEOG7RZ5SG.
PhylomeDBiQ03958.
TreeFamiTF315166.

Miscellaneous databases

PROiQ03958.
SOURCEiSearch...

Gene expression databases

BgeeiQ03958.
CleanExiMM_H2-KE2.
ExpressionAtlasiQ03958. baseline and differential.
GenevisibleiQ03958. MM.

Family and domain databases

Gene3Di1.10.287.370. 1 hit.
InterProiIPR002777. PFD_beta-like.
IPR009053. Prefoldin.
[Graphical view]
PfamiPF01920. Prefoldin_2. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of the embryo-expressed gene KE2 from the mouse H-2K region."
    Ha H., Abe K., Artzt K.
    Gene 107:345-346(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Liver.
  2. "Sequence of the mouse major histocomaptibility locus class II region."
    Rowen L., Qin S., Madan A., Loretz C., James R., Dors M., Mix L., Hall J., Lasky S., Hood L.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary gland.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiPFD6_MOUSE
AccessioniPrimary (citable) accession number: Q03958
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.