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Protein

Ribosomal lysine N-methyltransferase 2

Gene

RKM2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates 60S ribosomal protein L12 (RPL12A and RPL12B) at 'Lys-4' and 'Lys-11'.2 Publications

Miscellaneous

Present with 768 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei324S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein-lysine N-methyltransferase activity Source: SGD

GO - Biological processi

  • peptidyl-lysine monomethylation Source: SGD
  • peptidyl-lysine trimethylation Source: SGD
  • ribosome biogenesis Source: GO_Central

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-29784-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal lysine N-methyltransferase 21 Publication (EC:2.1.1.-1 Publication)
Gene namesi
Name:RKM21 Publication
Ordered Locus Names:YDR198CImported
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR198C
SGDiS000002606 RKM2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538091 – 479Ribosomal lysine N-methyltransferase 2Add BLAST479

Proteomic databases

MaxQBiQ03942
PaxDbiQ03942
PRIDEiQ03942

Interactioni

Protein-protein interaction databases

BioGridi32250, 53 interactors
DIPiDIP-6397N
IntActiQ03942, 3 interactors
STRINGi4932.YDR198C

Structurei

3D structure databases

ProteinModelPortaliQ03942
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 325SETPROSITE-ProRule annotationAdd BLAST304

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM2 family.PROSITE-ProRule annotationCurated

Phylogenomic databases

HOGENOMiHOG000001042
InParanoidiQ03942
OMAiGPHSNEF
OrthoDBiEOG092C2Z81

Family and domain databases

InterProiView protein in InterPro
IPR001214 SET_dom
IPR016852 SET_MeTrfase
PfamiView protein in Pfam
PF00856 SET, 1 hit
PIRSFiPIRSF027158 Lys_MTase_YDR198C_prd, 1 hit
PROSITEiView protein in PROSITE
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

Q03942-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGKVDVLLT WLKKSDKFYI APNISICESP ETGRGIVLSH GSIRKNDIIV
60 70 80 90 100
SVPSSKQLNF HTILYHISKF NKELNIPGIT IDRKPINYED NIIEAENKAW
110 120 130 140 150
ADPRYGLYSE LSKEFLLSLS SFQLVSFYIL VENFLLPKWT HNEIYSDWKP
160 170 180 190 200
FFDVWPSMEE LRSIPAIWNC DPNSRYHSLI EYLPAASRKH MARISGLVRE
210 220 230 240 250
DWETISEVVL KWNEIYGSLS CTKNSDKFTS DELFSLFVHV YFIINSRCLY
260 270 280 290 300
AKIPLKIEDS PSNFTLVPYV DFMNHICESD LHCYPQLSPQ LRSEGENIIG
310 320 330 340 350
IGQFTIRCGD HLYDNINEEL FLNYGAHSND FLLNEYGFVV DGNKWNYLDI
360 370 380 390 400
SDEIIELIDD DKKEVKTFLL EHDYWGDYTI NETDISYRIF VALNYYVTRD
410 420 430 440 450
ERRVRKFIEG YISEDYFKPK ISSVLKELLV SLTAKYTKTL SELTEKVSNL
460 470
ENNLCLQNLI TIYKGYIKIL TQHLQDLQS
Length:479
Mass (Da):55,950
Last modified:November 1, 1996 - v1
Checksum:i4E19ADFADEE1A0A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48784 Genomic DNA Translation: CAA88711.1
BK006938 Genomic DNA Translation: DAA12041.1
PIRiS52705
RefSeqiNP_010484.1, NM_001180506.1

Genome annotation databases

EnsemblFungiiYDR198C; YDR198C; YDR198C
GeneIDi851779
KEGGisce:YDR198C

Similar proteinsi

Entry informationi

Entry nameiRKM2_YEAST
AccessioniPrimary (citable) accession number: Q03942
Secondary accession number(s): D6VSI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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