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Protein

Dephospho-CoA kinase CAB5

Gene

CAB5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.1 Publication

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase CAB1 (CAB1)
  2. Phosphopantothenate--cysteine ligase CAB2 (CAB2)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Dephospho-CoA kinase CAB5 (CAB5)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • dephospho-CoA kinase activity Source: SGD

GO - Biological processi

  • coenzyme A biosynthetic process Source: SGD

Keywordsi

Molecular functionKinase, Transferase
Biological processCoenzyme A biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-504
YEAST:MONOMER3O-504
UniPathwayiUPA00241; UER00356

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase CAB5 (EC:2.7.1.24)
Short name:
DPCK
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:CAB5
Ordered Locus Names:YDR196C
ORF Names:YD9346.07C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi

Organism-specific databases

EuPathDBiFungiDB:YDR196C
SGDiS000002604 CAB5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Mitochondrion, Nucleus

Pathology & Biotechi

Disruption phenotypei

Lethal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730431 – 241Dephospho-CoA kinase CAB5Add BLAST241

Proteomic databases

MaxQBiQ03941
PaxDbiQ03941
PRIDEiQ03941

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi32248, 304 interactors
DIPiDIP-5705N
IntActiQ03941, 19 interactors
STRINGi4932.YDR196C

Structurei

3D structure databases

ProteinModelPortaliQ03941
SMRiQ03941
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 211DPCKAdd BLAST209

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075038
HOGENOMiHOG000020768
InParanoidiQ03941
KOiK00859
OMAiLVTEIWV
OrthoDBiEOG092C5E6X

Family and domain databases

CDDicd02022 DPCK, 1 hit
HAMAPiMF_00376 Dephospho_CoA_kinase, 1 hit
InterProiView protein in InterPro
IPR001977 Depp_CoAkinase
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01121 CoaE, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00152 TIGR00152, 1 hit
PROSITEiView protein in PROSITE
PS51219 DPCK, 1 hit

Sequencei

Sequence statusi: Complete.

Q03941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVVGLTGGI ACGKSTVSRR LRDKYKLPIV DADKIARQVV EPGQNAYDQI
60 70 80 90 100
VLYFKDKIPN LLLEDGHLNR EALGKWVFSH KEDLQALNGI THPAIRYAMF
110 120 130 140 150
KEIGYYYLKG YRMCVLDVPL LFEGNLDSIC GVTVSVICTQ ELQLERLMTR
160 170 180 190 200
NPELSEEDAK NRLNSQMSTE ERMARSDYIL QNNSTLVDLY EQIESVVKKI
210 220 230 240
QPSKLRTVLE YFPPFGAVSA SSIVMSRLLM KKLQNKKSSA V
Length:241
Mass (Da):27,340
Last modified:November 1, 1996 - v1
Checksum:i1E71FDB8A107CB6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48784 Genomic DNA Translation: CAA88709.1
AY557679 Genomic DNA Translation: AAS56005.1
BK006938 Genomic DNA Translation: DAA12039.1
PIRiS52703
RefSeqiNP_010482.3, NM_001180504.3

Genome annotation databases

EnsemblFungiiYDR196C; YDR196C; YDR196C
GeneIDi851777
KEGGisce:YDR196C

Similar proteinsi

Entry informationi

Entry nameiCAB5_YEAST
AccessioniPrimary (citable) accession number: Q03941
Secondary accession number(s): D6VSH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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