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Protein

Dephospho-CoA kinase CAB5

Gene

CAB5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.1 Publication

Catalytic activityi

ATP + 3'-dephospho-CoA = ADP + CoA.

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 5 of the subpathway that synthesizes CoA from (R)-pantothenate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase CAB1 (CAB1)
  2. Phosphopantothenate--cysteine ligase CAB2 (CAB2)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. Dephospho-CoA kinase CAB5 (CAB5)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 15ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • dephospho-CoA kinase activity Source: SGD

GO - Biological processi

  • coenzyme A biosynthetic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER3O-504.
YEAST:MONOMER3O-504.
UniPathwayiUPA00241; UER00356.

Names & Taxonomyi

Protein namesi
Recommended name:
Dephospho-CoA kinase CAB5 (EC:2.7.1.24)
Short name:
DPCK
Alternative name(s):
Dephosphocoenzyme A kinase
Gene namesi
Name:CAB5
Ordered Locus Names:YDR196C
ORF Names:YD9346.07C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR196C.
SGDiS000002604. CAB5.

Subcellular locationi

GO - Cellular componenti

  • CoA-synthesizing protein complex Source: SGD
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • lipid particle Source: SGD
  • mitochondrion Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Mitochondrion, Nucleus

Pathology & Biotechi

Disruption phenotypei

Lethal.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001730431 – 241Dephospho-CoA kinase CAB5Add BLAST241

Proteomic databases

MaxQBiQ03941.
PRIDEiQ03941.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CAB3P360767EBI-22174,EBI-26778
CAB4P533326EBI-22174,EBI-23648

Protein-protein interaction databases

BioGridi32248. 25 interactors.
DIPiDIP-5705N.
IntActiQ03941. 18 interactors.
MINTiMINT-514736.

Structurei

3D structure databases

ProteinModelPortaliQ03941.
SMRiQ03941.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 211DPCKAdd BLAST209

Sequence similaritiesi

Belongs to the CoaE family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000075038.
HOGENOMiHOG000020768.
InParanoidiQ03941.
KOiK00859.
OMAiVSCDSEK.
OrthoDBiEOG092C5E6X.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03941-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVVGLTGGI ACGKSTVSRR LRDKYKLPIV DADKIARQVV EPGQNAYDQI
60 70 80 90 100
VLYFKDKIPN LLLEDGHLNR EALGKWVFSH KEDLQALNGI THPAIRYAMF
110 120 130 140 150
KEIGYYYLKG YRMCVLDVPL LFEGNLDSIC GVTVSVICTQ ELQLERLMTR
160 170 180 190 200
NPELSEEDAK NRLNSQMSTE ERMARSDYIL QNNSTLVDLY EQIESVVKKI
210 220 230 240
QPSKLRTVLE YFPPFGAVSA SSIVMSRLLM KKLQNKKSSA V
Length:241
Mass (Da):27,340
Last modified:November 1, 1996 - v1
Checksum:i1E71FDB8A107CB6D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48784 Genomic DNA. Translation: CAA88709.1.
AY557679 Genomic DNA. Translation: AAS56005.1.
BK006938 Genomic DNA. Translation: DAA12039.1.
PIRiS52703.
RefSeqiNP_010482.3. NM_001180504.3.

Genome annotation databases

EnsemblFungiiYDR196C; YDR196C; YDR196C.
GeneIDi851777.
KEGGisce:YDR196C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48784 Genomic DNA. Translation: CAA88709.1.
AY557679 Genomic DNA. Translation: AAS56005.1.
BK006938 Genomic DNA. Translation: DAA12039.1.
PIRiS52703.
RefSeqiNP_010482.3. NM_001180504.3.

3D structure databases

ProteinModelPortaliQ03941.
SMRiQ03941.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32248. 25 interactors.
DIPiDIP-5705N.
IntActiQ03941. 18 interactors.
MINTiMINT-514736.

Proteomic databases

MaxQBiQ03941.
PRIDEiQ03941.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR196C; YDR196C; YDR196C.
GeneIDi851777.
KEGGisce:YDR196C.

Organism-specific databases

EuPathDBiFungiDB:YDR196C.
SGDiS000002604. CAB5.

Phylogenomic databases

GeneTreeiENSGT00550000075038.
HOGENOMiHOG000020768.
InParanoidiQ03941.
KOiK00859.
OMAiVSCDSEK.
OrthoDBiEOG092C5E6X.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00356.
BioCyciMetaCyc:MONOMER3O-504.
YEAST:MONOMER3O-504.

Miscellaneous databases

PROiQ03941.

Family and domain databases

CDDicd02022. DPCK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00376. Dephospho_CoA_kinase. 1 hit.
InterProiIPR001977. Depp_CoAkinase.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01121. CoaE. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00152. TIGR00152. 1 hit.
PROSITEiPS51219. DPCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAB5_YEAST
AccessioniPrimary (citable) accession number: Q03941
Secondary accession number(s): D6VSH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1660 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.