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Protein

Zinc finger protein 90

Gene

ZNF90

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: UniProtKB
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 90
Alternative name(s):
Zinc finger protein HTF9
Gene namesi
Name:ZNF90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000213988.9
HGNCiHGNC:13165 ZNF90
MIMi603973 gene
neXtProtiNX_Q03938

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213988
PharmGKBiPA37738

Polymorphism and mutation databases

BioMutaiZNF90
DMDMi300669708

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473991 – 601Zinc finger protein 90Add BLAST601

Proteomic databases

EPDiQ03938
MaxQBiQ03938
PaxDbiQ03938
PeptideAtlasiQ03938
PRIDEiQ03938

PTM databases

iPTMnetiQ03938
PhosphoSitePlusiQ03938

Expressioni

Developmental stagei

Expressed early during embryonic development.

Gene expression databases

BgeeiENSG00000213988
CleanExiHS_ZNF90
ExpressionAtlasiQ03938 baseline and differential
GenevisibleiQ03938 HS

Organism-specific databases

HPAiHPA003227

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410466

Structurei

3D structure databases

ProteinModelPortaliQ03938
SMRiQ03938
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144042
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ03938
KOiK09228
OMAiSHKISHT
OrthoDBiEOG091G02KC
PhylomeDBiQ03938
TreeFamiTF342117

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 15 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 15 hits
PS50157 ZINC_FINGER_C2H2_2, 15 hits

Sequencei

Sequence statusi: Complete.

Q03938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLEFRDVA IEFSLEEWHC LDTAQQNLYR DVMLENYRHL VFLGIVVTKP
60 70 80 90 100
DLITCLEQGK KPFTVKRHEM IAKSPVMCFH FAQDLCPEQS LKDSFQKVIV
110 120 130 140 150
TRYEKREYGN LELKKGCESV DEGKVHKRGY NGLNQCLTAT QSKVFQCDTY
160 170 180 190 200
VKVSHIFSNS NRHKIRDTGK KPFKCIECGK AFNQSSTLAT HKKIHTGEIT
210 220 230 240 250
CKCEECGKAF NRSSHLTSHK RIHTGEKRYK CEDCGKELKY SSTLTAHKRI
260 270 280 290 300
HTGEKRYKCE DCGKELKYSS TLTAHKRIHT GEKPYKCDKC GRAFISSSIL
310 320 330 340 350
YVHKISHTEE KPYKCEECGK AFKLSSILST HKRIHTGEKP YKCEECGKAF
360 370 380 390 400
RRSLVLRTHK RIHTGEKPYK CDKCGKAFIS SSLLYKHKIS HSEKKPYKCE
410 420 430 440 450
ECGKAFKRSS TLTIHKISHT EEKPYKCQEC DKVFKRSSAL STHKIIHSGE
460 470 480 490 500
KPYKCEECGK AFKRSSNLTT HKISHTEEKL YKCQECDKAF KYSSALSTHK
510 520 530 540 550
IIHSGENPYK CEECGKAFKR SSVLSKHKII HTGAKPYKCE ECGKAFKRSS
560 570 580 590 600
QLTSHKISHT GEKPYKCEEC GKAFNLSSDL NTHKRIHIGQ KAYIVKNMAN

L
Length:601
Mass (Da):69,058
Last modified:July 13, 2010 - v3
Checksum:iDEF44E0762A0C74D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011447 Genomic DNA No translation available.
BC137211 mRNA Translation: AAI37212.1
CN386341 mRNA No translation available.
M61870 mRNA Translation: AAA36028.1
CCDSiCCDS46028.1
PIRiE39384
RefSeqiNP_009069.1, NM_007138.1
UniGeneiHs.55304

Genome annotation databases

EnsembliENST00000418063; ENSP00000410466; ENSG00000213988
GeneIDi7643
KEGGihsa:7643
UCSCiuc002nor.3 human

Similar proteinsi

Entry informationi

Entry nameiZNF90_HUMAN
AccessioniPrimary (citable) accession number: Q03938
Secondary accession number(s): B9EH87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 13, 2010
Last modified: May 23, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health