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Protein

Zinc finger protein 90

Gene

ZNF90

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104777-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 90
Alternative name(s):
Zinc finger protein HTF9
Gene namesi
Name:ZNF90
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13165. ZNF90.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000213988.
PharmGKBiPA37738.

Polymorphism and mutation databases

BioMutaiZNF90.
DMDMi300669708.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473991 – 601Zinc finger protein 90Add BLAST601

Proteomic databases

EPDiQ03938.
MaxQBiQ03938.
PaxDbiQ03938.
PeptideAtlasiQ03938.
PRIDEiQ03938.

PTM databases

iPTMnetiQ03938.
PhosphoSitePlusiQ03938.

Expressioni

Developmental stagei

Expressed early during embryonic development.

Gene expression databases

BgeeiENSG00000213988.
CleanExiHS_ZNF90.
ExpressionAtlasiQ03938. baseline and differential.
GenevisibleiQ03938. HS.

Organism-specific databases

HPAiHPA003227.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000410466.

Structurei

3D structure databases

ProteinModelPortaliQ03938.
SMRiQ03938.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 15 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri173 – 195C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri201 – 223C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 15PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ03938.
KOiK09228.
OMAiKELKYSS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ03938.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03938-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLEFRDVA IEFSLEEWHC LDTAQQNLYR DVMLENYRHL VFLGIVVTKP
60 70 80 90 100
DLITCLEQGK KPFTVKRHEM IAKSPVMCFH FAQDLCPEQS LKDSFQKVIV
110 120 130 140 150
TRYEKREYGN LELKKGCESV DEGKVHKRGY NGLNQCLTAT QSKVFQCDTY
160 170 180 190 200
VKVSHIFSNS NRHKIRDTGK KPFKCIECGK AFNQSSTLAT HKKIHTGEIT
210 220 230 240 250
CKCEECGKAF NRSSHLTSHK RIHTGEKRYK CEDCGKELKY SSTLTAHKRI
260 270 280 290 300
HTGEKRYKCE DCGKELKYSS TLTAHKRIHT GEKPYKCDKC GRAFISSSIL
310 320 330 340 350
YVHKISHTEE KPYKCEECGK AFKLSSILST HKRIHTGEKP YKCEECGKAF
360 370 380 390 400
RRSLVLRTHK RIHTGEKPYK CDKCGKAFIS SSLLYKHKIS HSEKKPYKCE
410 420 430 440 450
ECGKAFKRSS TLTIHKISHT EEKPYKCQEC DKVFKRSSAL STHKIIHSGE
460 470 480 490 500
KPYKCEECGK AFKRSSNLTT HKISHTEEKL YKCQECDKAF KYSSALSTHK
510 520 530 540 550
IIHSGENPYK CEECGKAFKR SSVLSKHKII HTGAKPYKCE ECGKAFKRSS
560 570 580 590 600
QLTSHKISHT GEKPYKCEEC GKAFNLSSDL NTHKRIHIGQ KAYIVKNMAN

L
Length:601
Mass (Da):69,058
Last modified:July 13, 2010 - v3
Checksum:iDEF44E0762A0C74D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011447 Genomic DNA. No translation available.
BC137211 mRNA. Translation: AAI37212.1.
CN386341 mRNA. No translation available.
M61870 mRNA. Translation: AAA36028.1.
CCDSiCCDS46028.1.
PIRiE39384.
RefSeqiNP_009069.1. NM_007138.1.
UniGeneiHs.55304.

Genome annotation databases

EnsembliENST00000418063; ENSP00000410466; ENSG00000213988.
GeneIDi7643.
KEGGihsa:7643.
UCSCiuc002nor.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011447 Genomic DNA. No translation available.
BC137211 mRNA. Translation: AAI37212.1.
CN386341 mRNA. No translation available.
M61870 mRNA. Translation: AAA36028.1.
CCDSiCCDS46028.1.
PIRiE39384.
RefSeqiNP_009069.1. NM_007138.1.
UniGeneiHs.55304.

3D structure databases

ProteinModelPortaliQ03938.
SMRiQ03938.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000410466.

PTM databases

iPTMnetiQ03938.
PhosphoSitePlusiQ03938.

Polymorphism and mutation databases

BioMutaiZNF90.
DMDMi300669708.

Proteomic databases

EPDiQ03938.
MaxQBiQ03938.
PaxDbiQ03938.
PeptideAtlasiQ03938.
PRIDEiQ03938.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000418063; ENSP00000410466; ENSG00000213988.
GeneIDi7643.
KEGGihsa:7643.
UCSCiuc002nor.3. human.

Organism-specific databases

CTDi7643.
GeneCardsiZNF90.
HGNCiHGNC:13165. ZNF90.
HPAiHPA003227.
MIMi603973. gene.
neXtProtiNX_Q03938.
OpenTargetsiENSG00000213988.
PharmGKBiPA37738.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ03938.
KOiK09228.
OMAiKELKYSS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ03938.
TreeFamiTF342117.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000104777-MONOMER.

Miscellaneous databases

GenomeRNAii7643.
PROiQ03938.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213988.
CleanExiHS_ZNF90.
ExpressionAtlasiQ03938. baseline and differential.
GenevisibleiQ03938. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 15 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
PF13912. zf-C2H2_6. 5 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZNF90_HUMAN
AccessioniPrimary (citable) accession number: Q03938
Secondary accession number(s): B9EH87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.