ID   ZNF92_HUMAN             Reviewed;         586 AA.
AC   Q03936; A6NNF9; Q8N492; Q8NB35;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 2.
DT   27-MAR-2024, entry version 202.
DE   RecName: Full=Zinc finger protein 92;
DE   AltName: Full=Zinc finger protein HTF12;
GN   Name=ZNF92;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP   ARG-492.
RC   TISSUE=Brain, and Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-195 (ISOFORM 3).
RX   PubMed=2023909; DOI=10.1073/pnas.88.9.3608;
RA   Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.;
RT   "The evolutionarily conserved Kruppel-associated box domain defines a
RT   subfamily of eukaryotic multifingered proteins.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- INTERACTION:
CC       Q03936; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12176441, EBI-16439278;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=Q03936-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q03936-2; Sequence=VSP_016964;
CC       Name=3;
CC         IsoId=Q03936-3; Sequence=VSP_016965;
CC   -!- DEVELOPMENTAL STAGE: Expressed early during embryonic development.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AK091618; BAC03708.1; -; mRNA.
DR   EMBL; AC092685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC036439; AAH36439.1; -; mRNA.
DR   EMBL; BC040594; AAH40594.1; -; mRNA.
DR   EMBL; M61872; AAA58673.1; -; mRNA.
DR   CCDS; CCDS34646.1; -. [Q03936-1]
DR   CCDS; CCDS47596.1; -. [Q03936-2]
DR   CCDS; CCDS75608.1; -. [Q03936-3]
DR   PIR; G39384; G39384.
DR   RefSeq; NP_001274461.1; NM_001287532.1. [Q03936-3]
DR   RefSeq; NP_001274462.1; NM_001287533.1.
DR   RefSeq; NP_001274463.1; NM_001287534.1.
DR   RefSeq; NP_009070.2; NM_007139.3. [Q03936-2]
DR   RefSeq; NP_689839.1; NM_152626.3. [Q03936-1]
DR   AlphaFoldDB; Q03936; -.
DR   SMR; Q03936; -.
DR   BioGRID; 127958; 57.
DR   IntAct; Q03936; 19.
DR   STRING; 9606.ENSP00000332595; -.
DR   iPTMnet; Q03936; -.
DR   PhosphoSitePlus; Q03936; -.
DR   BioMuta; ZNF92; -.
DR   DMDM; 85681871; -.
DR   EPD; Q03936; -.
DR   jPOST; Q03936; -.
DR   MassIVE; Q03936; -.
DR   MaxQB; Q03936; -.
DR   PaxDb; 9606-ENSP00000332595; -.
DR   PeptideAtlas; Q03936; -.
DR   ProteomicsDB; 58230; -. [Q03936-1]
DR   ProteomicsDB; 58231; -. [Q03936-2]
DR   ProteomicsDB; 58232; -. [Q03936-3]
DR   Antibodypedia; 14040; 102 antibodies from 18 providers.
DR   DNASU; 168374; -.
DR   Ensembl; ENST00000328747.12; ENSP00000332595.8; ENSG00000146757.14. [Q03936-1]
DR   Ensembl; ENST00000357512.3; ENSP00000350113.2; ENSG00000146757.14. [Q03936-3]
DR   Ensembl; ENST00000450302.2; ENSP00000396126.2; ENSG00000146757.14. [Q03936-2]
DR   GeneID; 168374; -.
DR   KEGG; hsa:168374; -.
DR   MANE-Select; ENST00000328747.12; ENSP00000332595.8; NM_152626.4; NP_689839.1.
DR   UCSC; uc003tua.5; human. [Q03936-1]
DR   AGR; HGNC:13168; -.
DR   CTD; 168374; -.
DR   DisGeNET; 168374; -.
DR   GeneCards; ZNF92; -.
DR   HGNC; HGNC:13168; ZNF92.
DR   HPA; ENSG00000146757; Low tissue specificity.
DR   MIM; 603974; gene.
DR   neXtProt; NX_Q03936; -.
DR   OpenTargets; ENSG00000146757; -.
DR   PharmGKB; PA37740; -.
DR   VEuPathDB; HostDB:ENSG00000146757; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT01100000263507; -.
DR   HOGENOM; CLU_002678_57_1_1; -.
DR   InParanoid; Q03936; -.
DR   OMA; HEMVDKT; -.
DR   OrthoDB; 3120079at2759; -.
DR   PhylomeDB; Q03936; -.
DR   TreeFam; TF342117; -.
DR   PathwayCommons; Q03936; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q03936; -.
DR   BioGRID-ORCS; 168374; 8 hits in 1105 CRISPR screens.
DR   ChiTaRS; ZNF92; human.
DR   GenomeRNAi; 168374; -.
DR   Pharos; Q03936; Tbio.
DR   PRO; PR:Q03936; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; Q03936; Protein.
DR   Bgee; ENSG00000146757; Expressed in endothelial cell and 185 other cell types or tissues.
DR   ExpressionAtlas; Q03936; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   Gene3D; 6.10.140.140; -; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 14.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   PANTHER; PTHR19818:SF162; ZINC FINGER PROTEIN 728-LIKE; 1.
DR   PANTHER; PTHR19818; ZINC FINGER PROTEIN ZIC AND GLI; 1.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 11.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 13.
DR   SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 9.
DR   SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 11.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
DR   Genevisible; Q03936; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..586
FT                   /note="Zinc finger protein 92"
FT                   /id="PRO_0000047401"
FT   DOMAIN          4..75
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         145..167
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         173..195
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         201..223
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         229..251
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         257..279
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         285..307
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         313..335
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         341..363
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         369..391
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         397..419
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         425..447
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         453..475
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         481..503
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         509..531
FT                   /note="C2H2-type 14; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         537..559
FT                   /note="C2H2-type 15; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         563..586
FT                   /note="C2H2-type 16; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VAR_SEQ         1..69
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_016964"
FT   VAR_SEQ         44..75
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:2023909"
FT                   /id="VSP_016965"
FT   VARIANT         122
FT                   /note="A -> V (in dbSNP:rs10265083)"
FT                   /id="VAR_052766"
FT   VARIANT         492
FT                   /note="Q -> R (in dbSNP:rs17853615)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_024843"
FT   VARIANT         527
FT                   /note="R -> H (in dbSNP:rs10239197)"
FT                   /id="VAR_052767"
FT   CONFLICT        25..26
FT                   /note="QR -> PG (in Ref. 4; AAA58673)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   586 AA;  68487 MW;  DEDD12A611676857 CRC64;
     MGPLTFRDVK IEFSLEEWQC LDTAQRNLYR DVMLENYRNL VFLGIAVSKP DLITWLEQGK
     EPWNLKRHEM VDKTPVMCSH FAQDVWPEHS IKDSFQKVIL RTYGKYGHEN LQLRKDHKSV
     DACKVYKGGY NGLNQCLTTT DSKIFQCDKY VKVFHKFPNV NRNKIRHTGK KPFKCKNRGK
     SFCMLSQLTQ HKKIHTREYS YKCEECGKAF NWSSTLTKHK IIHTGEKPYK CEECGKAFNR
     SSNLTKHKII HTGEKPYKCE ECGKAFNRSS TLTKHKRIHT EEKPYKCEEC GKAFNQFSIL
     NKHKRIHMED KPYKCEECGK AFRVFSILKK HKIIHTGEKP YKCEECGKAF NQFSNLTKHK
     IIHTGEKPYK CDECGKAFNQ SSTLTKHKRI HTGEKPYKCE ECGKAFKQSS TLTEHKIIHT
     GEKPYKCEKC GKAFSWSSAF TKHKRNHMED KPYKCEECGK AFSVFSTLTK HKIIHTREKP
     YKCEECGKAF NQSSIFTKHK IIHTEGKSYK CEKCGNAFNQ SSNLTARKII YTGEKPYKYE
     ECDKAFNKFS TLITHQIIYT GEKPCKHECG RAFNKSSNYT KEKLQT
//