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Q03936 (ZNF92_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 92
Alternative name(s):
Zinc finger protein HTF12
Gene names
Name:ZNF92
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be involved in transcriptional regulation.

Subcellular location

Nucleus Probable.

Developmental stage

Expressed early during embryonic development.

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 16 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Non-traceable author statement Ref.4. Source: UniProtKB

zinc ion binding

Non-traceable author statement Ref.4. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q03936-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q03936-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q03936-3)

The sequence of this isoform differs from the canonical sequence as follows:
     44-75: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Zinc finger protein 92
PRO_0000047401

Regions

Domain4 – 7572KRAB
Zinc finger145 – 16723C2H2-type 1; degenerate
Zinc finger173 – 19523C2H2-type 2; degenerate
Zinc finger201 – 22323C2H2-type 3
Zinc finger229 – 25123C2H2-type 4
Zinc finger257 – 27923C2H2-type 5
Zinc finger285 – 30723C2H2-type 6
Zinc finger313 – 33523C2H2-type 7
Zinc finger341 – 36323C2H2-type 8
Zinc finger369 – 39123C2H2-type 9
Zinc finger397 – 41923C2H2-type 10
Zinc finger425 – 44723C2H2-type 11
Zinc finger453 – 47523C2H2-type 12
Zinc finger481 – 50323C2H2-type 13
Zinc finger509 – 53123C2H2-type 14; degenerate
Zinc finger537 – 55923C2H2-type 15; degenerate
Zinc finger563 – 58624C2H2-type 16; degenerate

Natural variations

Alternative sequence1 – 6969Missing in isoform 2.
VSP_016964
Alternative sequence44 – 7532Missing in isoform 3.
VSP_016965
Natural variant1221A → V.
Corresponds to variant rs10265083 [ dbSNP | Ensembl ].
VAR_052766
Natural variant4921Q → R. Ref.3
Corresponds to variant rs17853615 [ dbSNP | Ensembl ].
VAR_024843
Natural variant5271R → H.
Corresponds to variant rs10239197 [ dbSNP | Ensembl ].
VAR_052767

Experimental info

Sequence conflict25 – 262QR → PG in AAA58673. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: DEDD12A611676857

FASTA58668,487
        10         20         30         40         50         60 
MGPLTFRDVK IEFSLEEWQC LDTAQRNLYR DVMLENYRNL VFLGIAVSKP DLITWLEQGK 

        70         80         90        100        110        120 
EPWNLKRHEM VDKTPVMCSH FAQDVWPEHS IKDSFQKVIL RTYGKYGHEN LQLRKDHKSV 

       130        140        150        160        170        180 
DACKVYKGGY NGLNQCLTTT DSKIFQCDKY VKVFHKFPNV NRNKIRHTGK KPFKCKNRGK 

       190        200        210        220        230        240 
SFCMLSQLTQ HKKIHTREYS YKCEECGKAF NWSSTLTKHK IIHTGEKPYK CEECGKAFNR 

       250        260        270        280        290        300 
SSNLTKHKII HTGEKPYKCE ECGKAFNRSS TLTKHKRIHT EEKPYKCEEC GKAFNQFSIL 

       310        320        330        340        350        360 
NKHKRIHMED KPYKCEECGK AFRVFSILKK HKIIHTGEKP YKCEECGKAF NQFSNLTKHK 

       370        380        390        400        410        420 
IIHTGEKPYK CDECGKAFNQ SSTLTKHKRI HTGEKPYKCE ECGKAFKQSS TLTEHKIIHT 

       430        440        450        460        470        480 
GEKPYKCEKC GKAFSWSSAF TKHKRNHMED KPYKCEECGK AFSVFSTLTK HKIIHTREKP 

       490        500        510        520        530        540 
YKCEECGKAF NQSSIFTKHK IIHTEGKSYK CEKCGNAFNQ SSNLTARKII YTGEKPYKYE 

       550        560        570        580 
ECDKAFNKFS TLITHQIIYT GEKPCKHECG RAFNKSSNYT KEKLQT 

« Hide

Isoform 2 [UniParc].

Checksum: 17CC13FAE888A1C2
Show »

FASTA51760,209
Isoform 3 [UniParc].

Checksum: 8A3AD638D576F718
Show »

FASTA55464,788

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain.
[2]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-492.
Tissue: Brain and Testis.
[4]"The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195 (ISOFORM 3).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK091618 mRNA. Translation: BAC03708.1.
AC092685 Genomic DNA. No translation available.
BC036439 mRNA. Translation: AAH36439.1.
BC040594 mRNA. Translation: AAH40594.1.
M61872 mRNA. Translation: AAA58673.1.
CCDSCCDS34646.1. [Q03936-1]
CCDS47596.1. [Q03936-2]
PIRG39384.
RefSeqNP_001274461.1. NM_001287532.1. [Q03936-3]
NP_001274462.1. NM_001287533.1.
NP_001274463.1. NM_001287534.1.
NP_009070.2. NM_007139.3. [Q03936-2]
NP_689839.1. NM_152626.3. [Q03936-1]
UniGeneHs.9521.

3D structure databases

ProteinModelPortalQ03936.
SMRQ03936. Positions 4-44, 138-570.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127958. 3 interactions.
STRING9606.ENSP00000332595.

PTM databases

PhosphoSiteQ03936.

Polymorphism databases

DMDM85681871.

Proteomic databases

MaxQBQ03936.
PaxDbQ03936.
PRIDEQ03936.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000328747; ENSP00000332595; ENSG00000146757. [Q03936-1]
ENST00000357512; ENSP00000350113; ENSG00000146757. [Q03936-3]
ENST00000450302; ENSP00000396126; ENSG00000146757. [Q03936-2]
GeneID168374.
KEGGhsa:168374.
UCSCuc003ttz.3. human. [Q03936-1]
uc010kzu.3. human. [Q03936-3]

Organism-specific databases

CTD168374.
GeneCardsGC07P064838.
HGNCHGNC:13168. ZNF92.
HPAHPA003173.
MIM603974. gene.
neXtProtNX_Q03936.
PharmGKBPA37740.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ03936.
OMAHMEDKPY.
OrthoDBEOG7KSX7Q.
PhylomeDBQ03936.
TreeFamTF342117.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ03936.
BgeeQ03936.
CleanExHS_ZNF92.
GenevestigatorQ03936.

Family and domain databases

Gene3D3.30.160.60. 14 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi168374.
NextBio88708.
PROQ03936.
SOURCESearch...

Entry information

Entry nameZNF92_HUMAN
AccessionPrimary (citable) accession number: Q03936
Secondary accession number(s): A6NNF9, Q8N492, Q8NB35
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 10, 2006
Last modified: July 9, 2014
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM