Q03936 (ZNF92_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 92

Alternative name(s):
Zinc finger protein HTF12

Gene names

Name:

ZNF92

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	586 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Developmental stage	Expressed early during embryonic development.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 16 C2H2-type zinc fingers. Contains 1 KRAB domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Non-traceable author statement Ref.4. Source: UniProtKB zinc ion binding Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q03936-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q03936-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q03936-3)

The sequence of this isoform differs from the canonical sequence as follows:
     44-75: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 586	586	Zinc finger protein 92		PRO_0000047401
Regions
	Domain	4 – 75	72	KRAB
	Zinc finger	145 – 167	23	C2H2-type 1; degenerate
	Zinc finger	173 – 195	23	C2H2-type 2; degenerate
	Zinc finger	201 – 223	23	C2H2-type 3
	Zinc finger	229 – 251	23	C2H2-type 4
	Zinc finger	257 – 279	23	C2H2-type 5
	Zinc finger	285 – 307	23	C2H2-type 6
	Zinc finger	313 – 335	23	C2H2-type 7
	Zinc finger	341 – 363	23	C2H2-type 8
	Zinc finger	369 – 391	23	C2H2-type 9
	Zinc finger	397 – 419	23	C2H2-type 10
	Zinc finger	425 – 447	23	C2H2-type 11
	Zinc finger	453 – 475	23	C2H2-type 12
	Zinc finger	481 – 503	23	C2H2-type 13
	Zinc finger	509 – 531	23	C2H2-type 14; degenerate
	Zinc finger	537 – 559	23	C2H2-type 15; degenerate
	Zinc finger	563 – 586	24	C2H2-type 16; degenerate
Natural variations
	Alternative sequence	1 – 69	69	Missing in isoform 2.		VSP_016964
	Alternative sequence	44 – 75	32	Missing in isoform 3.		VSP_016965
	Natural variant	122	1	A → V. Corresponds to variant rs10265083 [ dbSNP | Ensembl ].		VAR_052766
	Natural variant	492	1	Q → R. Ref.3 Corresponds to variant rs17853615 [ dbSNP | Ensembl ].		VAR_024843
	Natural variant	527	1	R → H. Corresponds to variant rs10239197 [ dbSNP | Ensembl ].		VAR_052767
Experimental info
	Sequence conflict	25 – 26	2	QR → PG in AAA58673. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2006. Version 2. Checksum: DEDD12A611676857	FASTA	586	68,487
	10 20 30 40 50 60 MGPLTFRDVK IEFSLEEWQC LDTAQRNLYR DVMLENYRNL VFLGIAVSKP DLITWLEQGK 70 80 90 100 110 120 EPWNLKRHEM VDKTPVMCSH FAQDVWPEHS IKDSFQKVIL RTYGKYGHEN LQLRKDHKSV 130 140 150 160 170 180 DACKVYKGGY NGLNQCLTTT DSKIFQCDKY VKVFHKFPNV NRNKIRHTGK KPFKCKNRGK 190 200 210 220 230 240 SFCMLSQLTQ HKKIHTREYS YKCEECGKAF NWSSTLTKHK IIHTGEKPYK CEECGKAFNR 250 260 270 280 290 300 SSNLTKHKII HTGEKPYKCE ECGKAFNRSS TLTKHKRIHT EEKPYKCEEC GKAFNQFSIL 310 320 330 340 350 360 NKHKRIHMED KPYKCEECGK AFRVFSILKK HKIIHTGEKP YKCEECGKAF NQFSNLTKHK 370 380 390 400 410 420 IIHTGEKPYK CDECGKAFNQ SSTLTKHKRI HTGEKPYKCE ECGKAFKQSS TLTEHKIIHT 430 440 450 460 470 480 GEKPYKCEKC GKAFSWSSAF TKHKRNHMED KPYKCEECGK AFSVFSTLTK HKIIHTREKP 490 500 510 520 530 540 YKCEECGKAF NQSSIFTKHK IIHTEGKSYK CEKCGNAFNQ SSNLTARKII YTGEKPYKYE 550 560 570 580 ECDKAFNKFS TLITHQIIYT GEKPCKHECG RAFNKSSNYT KEKLQT
	Isoform 2 [UniParc]. Checksum: 17CC13FAE888A1C2	FASTA	517	60,209
	10 20 30 40 50 60 MVDKTPVMCS HFAQDVWPEH SIKDSFQKVI LRTYGKYGHE NLQLRKDHKS VDACKVYKGG 70 80 90 100 110 120 YNGLNQCLTT TDSKIFQCDK YVKVFHKFPN VNRNKIRHTG KKPFKCKNRG KSFCMLSQLT 130 140 150 160 170 180 QHKKIHTREY SYKCEECGKA FNWSSTLTKH KIIHTGEKPY KCEECGKAFN RSSNLTKHKI 190 200 210 220 230 240 IHTGEKPYKC EECGKAFNRS STLTKHKRIH TEEKPYKCEE CGKAFNQFSI LNKHKRIHME 250 260 270 280 290 300 DKPYKCEECG KAFRVFSILK KHKIIHTGEK PYKCEECGKA FNQFSNLTKH KIIHTGEKPY 310 320 330 340 350 360 KCDECGKAFN QSSTLTKHKR IHTGEKPYKC EECGKAFKQS STLTEHKIIH TGEKPYKCEK 370 380 390 400 410 420 CGKAFSWSSA FTKHKRNHME DKPYKCEECG KAFSVFSTLT KHKIIHTREK PYKCEECGKA 430 440 450 460 470 480 FNQSSIFTKH KIIHTEGKSY KCEKCGNAFN QSSNLTARKI IYTGEKPYKY EECDKAFNKF 490 500 510 STLITHQIIY TGEKPCKHEC GRAFNKSSNY TKEKLQT
	Isoform 3 [UniParc]. Checksum: 8A3AD638D576F718	FASTA	554	64,788
	10 20 30 40 50 60 MGPLTFRDVK IEFSLEEWQC LDTAQRNLYR DVMLENYRNL VFLVMCSHFA QDVWPEHSIK 70 80 90 100 110 120 DSFQKVILRT YGKYGHENLQ LRKDHKSVDA CKVYKGGYNG LNQCLTTTDS KIFQCDKYVK 130 140 150 160 170 180 VFHKFPNVNR NKIRHTGKKP FKCKNRGKSF CMLSQLTQHK KIHTREYSYK CEECGKAFNW 190 200 210 220 230 240 SSTLTKHKII HTGEKPYKCE ECGKAFNRSS NLTKHKIIHT GEKPYKCEEC GKAFNRSSTL 250 260 270 280 290 300 TKHKRIHTEE KPYKCEECGK AFNQFSILNK HKRIHMEDKP YKCEECGKAF RVFSILKKHK 310 320 330 340 350 360 IIHTGEKPYK CEECGKAFNQ FSNLTKHKII HTGEKPYKCD ECGKAFNQSS TLTKHKRIHT 370 380 390 400 410 420 GEKPYKCEEC GKAFKQSSTL TEHKIIHTGE KPYKCEKCGK AFSWSSAFTK HKRNHMEDKP 430 440 450 460 470 480 YKCEECGKAF SVFSTLTKHK IIHTREKPYK CEECGKAFNQ SSIFTKHKII HTEGKSYKCE 490 500 510 520 530 540 KCGNAFNQSS NLTARKIIYT GEKPYKYEEC DKAFNKFSTL ITHQIIYTGE KPCKHECGRA 550 FNKSSNYTKE KLQT

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-492. Tissue: Brain and Testis.
[4]	"The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins." Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A. Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195 (ISOFORM 3).
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK091618 mRNA. Translation: BAC03708.1. AC092685 Genomic DNA. No translation available. BC036439 mRNA. Translation: AAH36439.1. BC040594 mRNA. Translation: AAH40594.1. M61872 mRNA. Translation: AAA58673.1.
IPI	IPI00335720. IPI00395321. IPI00413088.
PIR	G39384.
RefSeq	NP_009070.2. NM_007139.2. NP_689839.1. NM_152626.2.
UniGene	Hs.9521.
3D structure databases
ProteinModelPortal	Q03936.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000332595.
PTM databases
PhosphoSite	Q03936.
Polymorphism databases
DMDM	85681871.
Proteomic databases
PaxDb	Q03936.
PRIDE	Q03936.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000328747; ENSP00000332595; ENSG00000146757. ENST00000357512; ENSP00000350113; ENSG00000146757. ENST00000450302; ENSP00000396126; ENSG00000146757.
GeneID	168374.
KEGG	hsa:168374.
UCSC	uc003ttz.3. human. uc010kzu.3. human.
Organism-specific databases
CTD	168374.
GeneCards	GC07P064838.
HGNC	HGNC:13168. ZNF92.
HPA	HPA003173.
MIM	603974. gene.
neXtProt	NX_Q03936.
PharmGKB	PA37740.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q03936.
OMA	HMEDKPY.
OrthoDB	EOG4JQ3X3.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q03936.
Bgee	Q03936.
CleanEx	HS_ZNF92.
Genevestigator	Q03936.
GermOnline	ENSG00000146757. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 14 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 13 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 11 hits. PS50157. ZINC_FINGER_C2H2_2. 14 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	168374.
NextBio	88708.
SOURCE	Search...

Entry information

Entry name

ZNF92_HUMAN

Accession

Primary (citable) accession number: Q03936
Secondary accession number(s): A6NNF9, Q8N492, Q8NB35

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 1994
Last sequence update:	January 10, 2006
Last modified:	May 1, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.