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Q03936

- ZNF92_HUMAN

UniProt

Q03936 - ZNF92_HUMAN

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Protein

Zinc finger protein 92

Gene

ZNF92

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58624C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  3. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 92
Alternative name(s):
Zinc finger protein HTF12
Gene namesi
Name:ZNF92
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:13168. ZNF92.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Zinc finger protein 92PRO_0000047401Add
BLAST

Proteomic databases

MaxQBiQ03936.
PaxDbiQ03936.
PRIDEiQ03936.

PTM databases

PhosphoSiteiQ03936.

Expressioni

Developmental stagei

Expressed early during embryonic development.

Gene expression databases

BgeeiQ03936.
CleanExiHS_ZNF92.
ExpressionAtlasiQ03936. baseline and differential.
GenevestigatoriQ03936.

Organism-specific databases

HPAiHPA003173.

Interactioni

Protein-protein interaction databases

BioGridi127958. 4 interactions.
STRINGi9606.ENSP00000332595.

Structurei

3D structure databases

ProteinModelPortaliQ03936.
SMRiQ03936. Positions 4-44, 138-570.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 16 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri145 – 16723C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri173 – 19523C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 30723C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri313 – 33523C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri341 – 36323C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri369 – 39123C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri397 – 41923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri425 – 44723C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri453 – 47523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri481 – 50323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri509 – 53123C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri537 – 55923C2H2-type 15; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri563 – 58624C2H2-type 16; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00550000074383.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ03936.
OMAiHMEDKPY.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ03936.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q03936-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLTFRDVK IEFSLEEWQC LDTAQRNLYR DVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITWLEQGK EPWNLKRHEM VDKTPVMCSH FAQDVWPEHS IKDSFQKVIL
110 120 130 140 150
RTYGKYGHEN LQLRKDHKSV DACKVYKGGY NGLNQCLTTT DSKIFQCDKY
160 170 180 190 200
VKVFHKFPNV NRNKIRHTGK KPFKCKNRGK SFCMLSQLTQ HKKIHTREYS
210 220 230 240 250
YKCEECGKAF NWSSTLTKHK IIHTGEKPYK CEECGKAFNR SSNLTKHKII
260 270 280 290 300
HTGEKPYKCE ECGKAFNRSS TLTKHKRIHT EEKPYKCEEC GKAFNQFSIL
310 320 330 340 350
NKHKRIHMED KPYKCEECGK AFRVFSILKK HKIIHTGEKP YKCEECGKAF
360 370 380 390 400
NQFSNLTKHK IIHTGEKPYK CDECGKAFNQ SSTLTKHKRI HTGEKPYKCE
410 420 430 440 450
ECGKAFKQSS TLTEHKIIHT GEKPYKCEKC GKAFSWSSAF TKHKRNHMED
460 470 480 490 500
KPYKCEECGK AFSVFSTLTK HKIIHTREKP YKCEECGKAF NQSSIFTKHK
510 520 530 540 550
IIHTEGKSYK CEKCGNAFNQ SSNLTARKII YTGEKPYKYE ECDKAFNKFS
560 570 580
TLITHQIIYT GEKPCKHECG RAFNKSSNYT KEKLQT
Length:586
Mass (Da):68,487
Last modified:January 10, 2006 - v2
Checksum:iDEDD12A611676857
GO
Isoform 2 (identifier: Q03936-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Note: No experimental confirmation available.

Show »
Length:517
Mass (Da):60,209
Checksum:i17CC13FAE888A1C2
GO
Isoform 3 (identifier: Q03936-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-75: Missing.

Note: No experimental confirmation available.

Show »
Length:554
Mass (Da):64,788
Checksum:i8A3AD638D576F718
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 262QR → PG in AAA58673. (PubMed:2023909)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti122 – 1221A → V.
Corresponds to variant rs10265083 [ dbSNP | Ensembl ].
VAR_052766
Natural varianti492 – 4921Q → R.1 Publication
Corresponds to variant rs17853615 [ dbSNP | Ensembl ].
VAR_024843
Natural varianti527 – 5271R → H.
Corresponds to variant rs10239197 [ dbSNP | Ensembl ].
VAR_052767

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 6969Missing in isoform 2. 1 PublicationVSP_016964Add
BLAST
Alternative sequencei44 – 7532Missing in isoform 3. 1 PublicationVSP_016965Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091618 mRNA. Translation: BAC03708.1.
AC092685 Genomic DNA. No translation available.
BC036439 mRNA. Translation: AAH36439.1.
BC040594 mRNA. Translation: AAH40594.1.
M61872 mRNA. Translation: AAA58673.1.
CCDSiCCDS34646.1. [Q03936-1]
CCDS47596.1. [Q03936-2]
CCDS75608.1. [Q03936-3]
PIRiG39384.
RefSeqiNP_001274461.1. NM_001287532.1. [Q03936-3]
NP_001274462.1. NM_001287533.1.
NP_001274463.1. NM_001287534.1.
NP_009070.2. NM_007139.3. [Q03936-2]
NP_689839.1. NM_152626.3. [Q03936-1]
UniGeneiHs.9521.

Genome annotation databases

EnsembliENST00000328747; ENSP00000332595; ENSG00000146757. [Q03936-1]
ENST00000357512; ENSP00000350113; ENSG00000146757. [Q03936-3]
ENST00000450302; ENSP00000396126; ENSG00000146757. [Q03936-2]
GeneIDi168374.
KEGGihsa:168374.
UCSCiuc003ttz.3. human. [Q03936-1]
uc010kzu.3. human. [Q03936-3]

Polymorphism databases

DMDMi85681871.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK091618 mRNA. Translation: BAC03708.1 .
AC092685 Genomic DNA. No translation available.
BC036439 mRNA. Translation: AAH36439.1 .
BC040594 mRNA. Translation: AAH40594.1 .
M61872 mRNA. Translation: AAA58673.1 .
CCDSi CCDS34646.1. [Q03936-1 ]
CCDS47596.1. [Q03936-2 ]
CCDS75608.1. [Q03936-3 ]
PIRi G39384.
RefSeqi NP_001274461.1. NM_001287532.1. [Q03936-3 ]
NP_001274462.1. NM_001287533.1.
NP_001274463.1. NM_001287534.1.
NP_009070.2. NM_007139.3. [Q03936-2 ]
NP_689839.1. NM_152626.3. [Q03936-1 ]
UniGenei Hs.9521.

3D structure databases

ProteinModelPortali Q03936.
SMRi Q03936. Positions 4-44, 138-570.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127958. 4 interactions.
STRINGi 9606.ENSP00000332595.

PTM databases

PhosphoSitei Q03936.

Polymorphism databases

DMDMi 85681871.

Proteomic databases

MaxQBi Q03936.
PaxDbi Q03936.
PRIDEi Q03936.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000328747 ; ENSP00000332595 ; ENSG00000146757 . [Q03936-1 ]
ENST00000357512 ; ENSP00000350113 ; ENSG00000146757 . [Q03936-3 ]
ENST00000450302 ; ENSP00000396126 ; ENSG00000146757 . [Q03936-2 ]
GeneIDi 168374.
KEGGi hsa:168374.
UCSCi uc003ttz.3. human. [Q03936-1 ]
uc010kzu.3. human. [Q03936-3 ]

Organism-specific databases

CTDi 168374.
GeneCardsi GC07P064838.
HGNCi HGNC:13168. ZNF92.
HPAi HPA003173.
MIMi 603974. gene.
neXtProti NX_Q03936.
PharmGKBi PA37740.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00550000074383.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q03936.
OMAi HMEDKPY.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q03936.
TreeFami TF342117.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii 168374.
NextBioi 88708.
PROi Q03936.
SOURCEi Search...

Gene expression databases

Bgeei Q03936.
CleanExi HS_ZNF92.
ExpressionAtlasi Q03936. baseline and differential.
Genevestigatori Q03936.

Family and domain databases

Gene3Di 3.30.160.60. 14 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ARG-492.
    Tissue: Brain and Testis.
  4. "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
    Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-195 (ISOFORM 3).

Entry informationi

Entry nameiZNF92_HUMAN
AccessioniPrimary (citable) accession number: Q03936
Secondary accession number(s): A6NNF9, Q8N492, Q8NB35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: January 10, 2006
Last modified: October 29, 2014
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3