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Q03933

- HSF2_HUMAN

UniProt

Q03933 - HSF2_HUMAN

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Protein

Heat shock factor protein 2

Gene

HSF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi7 – 112106By similarityAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: MGI
  2. sequence-specific DNA binding transcription factor activity Source: ProtInc
  3. transcription coactivator activity Source: ProtInc

GO - Biological processi

  1. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  2. response to stress Source: UniProtKB-KW
  3. spermatogenesis Source: Ensembl
  4. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Stress response, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ03933.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock factor protein 2
Short name:
HSF 2
Alternative name(s):
Heat shock transcription factor 2
Short name:
HSTF 2
Gene namesi
Name:HSF2
Synonyms:HSTF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:5225. HSF2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication
Note: Cytoplasmic during normal growth and moves to the nucleus upon activation.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi109 – 1091R → G: Fails to translocate to nucleus. 1 Publication
Mutagenesisi196 – 1983RKR → ASS: Fails to translocate to nucleus. 1 Publication

Organism-specific databases

PharmGKBiPA29494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 536536Heat shock factor protein 2PRO_0000124569Add
BLAST

Proteomic databases

MaxQBiQ03933.
PaxDbiQ03933.
PRIDEiQ03933.

PTM databases

PhosphoSiteiQ03933.

Expressioni

Gene expression databases

BgeeiQ03933.
CleanExiHS_HSF2.
ExpressionAtlasiQ03933. baseline and differential.
GenevestigatoriQ03933.

Organism-specific databases

HPAiCAB016067.
HPA031455.

Interactioni

Subunit structurei

DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.

Protein-protein interaction databases

BioGridi109531. 19 interactions.
IntActiQ03933. 39 interactions.
STRINGi9606.ENSP00000357440.

Structurei

3D structure databases

ProteinModelPortaliQ03933.
SMRiQ03933. Positions 1-113.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni119 – 19274Hydrophobic repeat HR-A/BAdd
BLAST
Regioni360 – 38526Hydrophobic repeat HR-CAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi108 – 12215Nuclear localization signalSequence AnalysisAdd
BLAST
Motifi195 – 21016Nuclear localization signalSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi170 – 1734Poly-Gln

Sequence similaritiesi

Belongs to the HSF family.Curated

Phylogenomic databases

eggNOGiCOG5169.
GeneTreeiENSGT00390000001182.
HOGENOMiHOG000253917.
HOVERGENiHBG005999.
InParanoidiQ03933.
KOiK09415.
OMAiPKTDKQL.
OrthoDBiEOG7353WM.
PhylomeDBiQ03933.
TreeFamiTF330401.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR027712. HSF2.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR010542. Vert_HSTF_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10015. PTHR10015. 1 hit.
PTHR10015:SF144. PTHR10015:SF144. 1 hit.
PfamiPF00447. HSF_DNA-bind. 1 hit.
PF06546. Vert_HS_TF. 1 hit.
[Graphical view]
PRINTSiPR00056. HSFDOMAIN.
SMARTiSM00415. HSF. 1 hit.
[Graphical view]
PROSITEiPS00434. HSF_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q03933-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP
60 70 80 90 100
KYFKHNNMAS FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ
110 120 130 140 150
DDLLENIKRK VSSSKPEENK IRQEDLTKII SSAQKVQIKQ ETIESRLSEL
160 170 180 190 200
KSENESLWKE VSELRAKHAQ QQQVIRKIVQ FIVTLVQNNQ LVSLKRKRPL
210 220 230 240 250
LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE RISDDIIIYD
260 270 280 290 300
VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ
310 320 330 340 350
SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND
360 370 380 390 400
NINLLGKVEL LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDLFTSSVQM
410 420 430 440 450
NPTDYINNTK SENKGLETTK NNVVQPVSEE GRKSKSKPDK QLIQYTAFPL
460 470 480 490 500
LAFLDGNPAS SVEQASTTAS SEVLSSVDKP IEVDELLDSS LDPEPTQSKL
510 520 530
VRLEPLTEAE ASEATLFYLC ELAPAPLDSD MPLLDS
Length:536
Mass (Da):60,348
Last modified:February 1, 1994 - v1
Checksum:i00DFD05CFD9DF0D3
GO
Isoform 2 (identifier: Q03933-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     393-410: Missing.

Show »
Length:518
Mass (Da):58,293
Checksum:i6682B51448E116BC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei393 – 41018Missing in isoform 2. 2 PublicationsVSP_041128Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65217 mRNA. Translation: AAA36017.1.
DQ492684 Genomic DNA. Translation: ABF47087.1.
AK294624 mRNA. Translation: BAG57805.1.
AK316377 mRNA. Translation: BAH14748.1.
AL121954, Z99129 Genomic DNA. Translation: CAC14262.2.
Z99129, AL121954 Genomic DNA. Translation: CAI20560.1.
CH471051 Genomic DNA. Translation: EAW48176.1.
BC112323 mRNA. Translation: AAI12324.1.
BC121050 mRNA. Translation: AAI21051.1.
BC121051 mRNA. Translation: AAI21052.1.
BC128420 mRNA. Translation: AAI28421.1.
CCDSiCCDS47470.1. [Q03933-2]
CCDS5124.1. [Q03933-1]
PIRiA41138.
RefSeqiNP_001129036.1. NM_001135564.1. [Q03933-2]
NP_004497.1. NM_004506.3. [Q03933-1]
UniGeneiHs.158195.

Genome annotation databases

EnsembliENST00000368455; ENSP00000357440; ENSG00000025156. [Q03933-1]
ENST00000452194; ENSP00000400380; ENSG00000025156. [Q03933-2]
GeneIDi3298.
KEGGihsa:3298.
UCSCiuc003pyu.2. human. [Q03933-1]
uc003pyv.2. human. [Q03933-2]

Polymorphism databases

DMDMi462334.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M65217 mRNA. Translation: AAA36017.1 .
DQ492684 Genomic DNA. Translation: ABF47087.1 .
AK294624 mRNA. Translation: BAG57805.1 .
AK316377 mRNA. Translation: BAH14748.1 .
AL121954 , Z99129 Genomic DNA. Translation: CAC14262.2 .
Z99129 , AL121954 Genomic DNA. Translation: CAI20560.1 .
CH471051 Genomic DNA. Translation: EAW48176.1 .
BC112323 mRNA. Translation: AAI12324.1 .
BC121050 mRNA. Translation: AAI21051.1 .
BC121051 mRNA. Translation: AAI21052.1 .
BC128420 mRNA. Translation: AAI28421.1 .
CCDSi CCDS47470.1. [Q03933-2 ]
CCDS5124.1. [Q03933-1 ]
PIRi A41138.
RefSeqi NP_001129036.1. NM_001135564.1. [Q03933-2 ]
NP_004497.1. NM_004506.3. [Q03933-1 ]
UniGenei Hs.158195.

3D structure databases

ProteinModelPortali Q03933.
SMRi Q03933. Positions 1-113.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109531. 19 interactions.
IntActi Q03933. 39 interactions.
STRINGi 9606.ENSP00000357440.

PTM databases

PhosphoSitei Q03933.

Polymorphism databases

DMDMi 462334.

Proteomic databases

MaxQBi Q03933.
PaxDbi Q03933.
PRIDEi Q03933.

Protocols and materials databases

DNASUi 3298.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368455 ; ENSP00000357440 ; ENSG00000025156 . [Q03933-1 ]
ENST00000452194 ; ENSP00000400380 ; ENSG00000025156 . [Q03933-2 ]
GeneIDi 3298.
KEGGi hsa:3298.
UCSCi uc003pyu.2. human. [Q03933-1 ]
uc003pyv.2. human. [Q03933-2 ]

Organism-specific databases

CTDi 3298.
GeneCardsi GC06P122762.
HGNCi HGNC:5225. HSF2.
HPAi CAB016067.
HPA031455.
MIMi 140581. gene.
neXtProti NX_Q03933.
PharmGKBi PA29494.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5169.
GeneTreei ENSGT00390000001182.
HOGENOMi HOG000253917.
HOVERGENi HBG005999.
InParanoidi Q03933.
KOi K09415.
OMAi PKTDKQL.
OrthoDBi EOG7353WM.
PhylomeDBi Q03933.
TreeFami TF330401.

Enzyme and pathway databases

SignaLinki Q03933.

Miscellaneous databases

GeneWikii HSF2.
GenomeRNAii 3298.
NextBioi 13083.
PROi Q03933.
SOURCEi Search...

Gene expression databases

Bgeei Q03933.
CleanExi HS_HSF2.
ExpressionAtlasi Q03933. baseline and differential.
Genevestigatori Q03933.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR027712. HSF2.
IPR000232. HSF_DNA-bd.
IPR027725. HSF_fam.
IPR010542. Vert_HSTF_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10015. PTHR10015. 1 hit.
PTHR10015:SF144. PTHR10015:SF144. 1 hit.
Pfami PF00447. HSF_DNA-bind. 1 hit.
PF06546. Vert_HS_TF. 1 hit.
[Graphical view ]
PRINTSi PR00056. HSFDOMAIN.
SMARTi SM00415. HSF. 1 hit.
[Graphical view ]
PROSITEi PS00434. HSF_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans."
    Schuetz T.J., Gallo G.J., Sheldon L., Tempst P., Kingston R.E.
    Proc. Natl. Acad. Sci. U.S.A. 88:6911-6915(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 65-71.
  2. NIEHS SNPs program
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  4. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
  7. "Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2."
    Sheldon L., Kingston R.E.
    Genes Dev. 7:1549-1558(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS.

Entry informationi

Entry nameiHSF2_HUMAN
AccessioniPrimary (citable) accession number: Q03933
Secondary accession number(s): B4DGJ4
, Q0VAH9, Q2M1K4, Q9H445
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: October 29, 2014
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3