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Q03933

- HSF2_HUMAN

UniProt

Q03933 - HSF2_HUMAN

Protein

Heat shock factor protein 2

Gene

HSF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 1 (01 Feb 1994)
      Previous versions | rss
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    Functioni

    DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi7 – 112106By similarityAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: ProtInc
    3. transcription coactivator activity Source: ProtInc

    GO - Biological processi

    1. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    2. response to stress Source: UniProtKB-KW
    3. spermatogenesis Source: Ensembl
    4. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Stress response, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ03933.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock factor protein 2
    Short name:
    HSF 2
    Alternative name(s):
    Heat shock transcription factor 2
    Short name:
    HSTF 2
    Gene namesi
    Name:HSF2
    Synonyms:HSTF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:5225. HSF2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Cytoplasmic during normal growth and moves to the nucleus upon activation.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi109 – 1091R → G: Fails to translocate to nucleus. 1 Publication
    Mutagenesisi196 – 1983RKR → ASS: Fails to translocate to nucleus. 1 Publication

    Organism-specific databases

    PharmGKBiPA29494.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 536536Heat shock factor protein 2PRO_0000124569Add
    BLAST

    Proteomic databases

    MaxQBiQ03933.
    PaxDbiQ03933.
    PRIDEiQ03933.

    PTM databases

    PhosphoSiteiQ03933.

    Expressioni

    Gene expression databases

    BgeeiQ03933.
    CleanExiHS_HSF2.
    GenevestigatoriQ03933.

    Organism-specific databases

    HPAiCAB016067.
    HPA031455.

    Interactioni

    Subunit structurei

    DNA-binding homotrimer in stressed or heat shocked cells, otherwise found as a homodimer.

    Protein-protein interaction databases

    BioGridi109531. 14 interactions.
    IntActiQ03933. 39 interactions.
    STRINGi9606.ENSP00000357440.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03933.
    SMRiQ03933. Positions 1-113.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni119 – 19274Hydrophobic repeat HR-A/BAdd
    BLAST
    Regioni360 – 38526Hydrophobic repeat HR-CAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi108 – 12215Nuclear localization signalSequence AnalysisAdd
    BLAST
    Motifi195 – 21016Nuclear localization signalSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi170 – 1734Poly-Gln

    Sequence similaritiesi

    Belongs to the HSF family.Curated

    Phylogenomic databases

    eggNOGiCOG5169.
    HOGENOMiHOG000253917.
    HOVERGENiHBG005999.
    InParanoidiQ03933.
    KOiK09415.
    OMAiPKTDKQL.
    OrthoDBiEOG7353WM.
    PhylomeDBiQ03933.
    TreeFamiTF330401.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR027712. HSF2.
    IPR000232. HSF_DNA-bd.
    IPR027725. HSF_fam.
    IPR010542. Vert_HSTF_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10015. PTHR10015. 1 hit.
    PTHR10015:SF144. PTHR10015:SF144. 1 hit.
    PfamiPF00447. HSF_DNA-bind. 1 hit.
    PF06546. Vert_HS_TF. 1 hit.
    [Graphical view]
    PRINTSiPR00056. HSFDOMAIN.
    SMARTiSM00415. HSF. 1 hit.
    [Graphical view]
    PROSITEiPS00434. HSF_DOMAIN. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q03933-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKQSSNVPAF LSKLWTLVEE THTNEFITWS QNGQSFLVLD EQRFAKEILP    50
    KYFKHNNMAS FVRQLNMYGF RKVVHIDSGI VKQERDGPVE FQHPYFKQGQ 100
    DDLLENIKRK VSSSKPEENK IRQEDLTKII SSAQKVQIKQ ETIESRLSEL 150
    KSENESLWKE VSELRAKHAQ QQQVIRKIVQ FIVTLVQNNQ LVSLKRKRPL 200
    LLNTNGAQKK NLFQHIVKEP TDNHHHKVPH SRTEGLKPRE RISDDIIIYD 250
    VTDDNADEEN IPVIPETNED VISDPSNCSQ YPDIVIVEDD NEDEYAPVIQ 300
    SGEQNEPARE SLSSGSDGSS PLMSSAVQLN GSSSLTSEDP VTMMDSILND 350
    NINLLGKVEL LDYLDSIDCS LEDFQAMLSG RQFSIDPDLL VDLFTSSVQM 400
    NPTDYINNTK SENKGLETTK NNVVQPVSEE GRKSKSKPDK QLIQYTAFPL 450
    LAFLDGNPAS SVEQASTTAS SEVLSSVDKP IEVDELLDSS LDPEPTQSKL 500
    VRLEPLTEAE ASEATLFYLC ELAPAPLDSD MPLLDS 536
    Length:536
    Mass (Da):60,348
    Last modified:February 1, 1994 - v1
    Checksum:i00DFD05CFD9DF0D3
    GO
    Isoform 2 (identifier: Q03933-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         393-410: Missing.

    Show »
    Length:518
    Mass (Da):58,293
    Checksum:i6682B51448E116BC
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei393 – 41018Missing in isoform 2. 2 PublicationsVSP_041128Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65217 mRNA. Translation: AAA36017.1.
    DQ492684 Genomic DNA. Translation: ABF47087.1.
    AK294624 mRNA. Translation: BAG57805.1.
    AK316377 mRNA. Translation: BAH14748.1.
    AL121954, Z99129 Genomic DNA. Translation: CAC14262.2.
    Z99129, AL121954 Genomic DNA. Translation: CAI20560.1.
    CH471051 Genomic DNA. Translation: EAW48176.1.
    BC112323 mRNA. Translation: AAI12324.1.
    BC121050 mRNA. Translation: AAI21051.1.
    BC121051 mRNA. Translation: AAI21052.1.
    BC128420 mRNA. Translation: AAI28421.1.
    CCDSiCCDS47470.1. [Q03933-2]
    CCDS5124.1. [Q03933-1]
    PIRiA41138.
    RefSeqiNP_001129036.1. NM_001135564.1. [Q03933-2]
    NP_004497.1. NM_004506.3. [Q03933-1]
    UniGeneiHs.158195.

    Genome annotation databases

    EnsembliENST00000368455; ENSP00000357440; ENSG00000025156. [Q03933-1]
    ENST00000452194; ENSP00000400380; ENSG00000025156. [Q03933-2]
    GeneIDi3298.
    KEGGihsa:3298.
    UCSCiuc003pyu.2. human. [Q03933-1]
    uc003pyv.2. human. [Q03933-2]

    Polymorphism databases

    DMDMi462334.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M65217 mRNA. Translation: AAA36017.1 .
    DQ492684 Genomic DNA. Translation: ABF47087.1 .
    AK294624 mRNA. Translation: BAG57805.1 .
    AK316377 mRNA. Translation: BAH14748.1 .
    AL121954 , Z99129 Genomic DNA. Translation: CAC14262.2 .
    Z99129 , AL121954 Genomic DNA. Translation: CAI20560.1 .
    CH471051 Genomic DNA. Translation: EAW48176.1 .
    BC112323 mRNA. Translation: AAI12324.1 .
    BC121050 mRNA. Translation: AAI21051.1 .
    BC121051 mRNA. Translation: AAI21052.1 .
    BC128420 mRNA. Translation: AAI28421.1 .
    CCDSi CCDS47470.1. [Q03933-2 ]
    CCDS5124.1. [Q03933-1 ]
    PIRi A41138.
    RefSeqi NP_001129036.1. NM_001135564.1. [Q03933-2 ]
    NP_004497.1. NM_004506.3. [Q03933-1 ]
    UniGenei Hs.158195.

    3D structure databases

    ProteinModelPortali Q03933.
    SMRi Q03933. Positions 1-113.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109531. 14 interactions.
    IntActi Q03933. 39 interactions.
    STRINGi 9606.ENSP00000357440.

    PTM databases

    PhosphoSitei Q03933.

    Polymorphism databases

    DMDMi 462334.

    Proteomic databases

    MaxQBi Q03933.
    PaxDbi Q03933.
    PRIDEi Q03933.

    Protocols and materials databases

    DNASUi 3298.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368455 ; ENSP00000357440 ; ENSG00000025156 . [Q03933-1 ]
    ENST00000452194 ; ENSP00000400380 ; ENSG00000025156 . [Q03933-2 ]
    GeneIDi 3298.
    KEGGi hsa:3298.
    UCSCi uc003pyu.2. human. [Q03933-1 ]
    uc003pyv.2. human. [Q03933-2 ]

    Organism-specific databases

    CTDi 3298.
    GeneCardsi GC06P122762.
    HGNCi HGNC:5225. HSF2.
    HPAi CAB016067.
    HPA031455.
    MIMi 140581. gene.
    neXtProti NX_Q03933.
    PharmGKBi PA29494.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5169.
    HOGENOMi HOG000253917.
    HOVERGENi HBG005999.
    InParanoidi Q03933.
    KOi K09415.
    OMAi PKTDKQL.
    OrthoDBi EOG7353WM.
    PhylomeDBi Q03933.
    TreeFami TF330401.

    Enzyme and pathway databases

    SignaLinki Q03933.

    Miscellaneous databases

    GeneWikii HSF2.
    GenomeRNAii 3298.
    NextBioi 13083.
    PROi Q03933.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q03933.
    CleanExi HS_HSF2.
    Genevestigatori Q03933.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR027712. HSF2.
    IPR000232. HSF_DNA-bd.
    IPR027725. HSF_fam.
    IPR010542. Vert_HSTF_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10015. PTHR10015. 1 hit.
    PTHR10015:SF144. PTHR10015:SF144. 1 hit.
    Pfami PF00447. HSF_DNA-bind. 1 hit.
    PF06546. Vert_HS_TF. 1 hit.
    [Graphical view ]
    PRINTSi PR00056. HSFDOMAIN.
    SMARTi SM00415. HSF. 1 hit.
    [Graphical view ]
    PROSITEi PS00434. HSF_DOMAIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans."
      Schuetz T.J., Gallo G.J., Sheldon L., Tempst P., Kingston R.E.
      Proc. Natl. Acad. Sci. U.S.A. 88:6911-6915(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 65-71.
    2. NIEHS SNPs program
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Brain.
    4. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    7. "Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2."
      Sheldon L., Kingston R.E.
      Genes Dev. 7:1549-1558(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS.

    Entry informationi

    Entry nameiHSF2_HUMAN
    AccessioniPrimary (citable) accession number: Q03933
    Secondary accession number(s): B4DGJ4
    , Q0VAH9, Q2M1K4, Q9H445
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: February 1, 1994
    Last modified: October 1, 2014
    This is version 133 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3