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Protein

Zinc finger protein 117

Gene

ZNF117

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 13123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri137 – 15923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: GO_Central
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 117
Alternative name(s):
Provirus-linked krueppel
Short name:
h-PLK
Zinc finger protein HPF9
Gene namesi
Name:ZNF117
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12897. ZNF117.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37486.

Polymorphism and mutation databases

BioMutaiZNF117.
DMDMi327478609.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Zinc finger protein 117PRO_0000047407Add
BLAST

Proteomic databases

PaxDbiQ03924.
PRIDEiQ03924.

PTM databases

iPTMnetiQ03924.
PhosphoSiteiQ03924.

Expressioni

Developmental stagei

Expressed early during embryonic development.

Gene expression databases

BgeeiQ03924.
CleanExiHS_ZNF117.
ExpressionAtlasiQ03924. baseline and differential.
GenevisibleiQ03924. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000282869.

Structurei

3D structure databases

ProteinModelPortaliQ03924.
SMRiQ03924. Positions 79-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri109 – 13123C2H2-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri137 – 15923C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri165 – 18723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri193 – 21523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri221 – 24323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri249 – 27123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri277 – 29923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri305 – 32723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri333 – 35523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri361 – 38323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri389 – 41123C2H2-type 11; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri417 – 43923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri445 – 46723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ03924.
OMAiSTLIGHK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ03924.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03924-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRHEMVAKH LVMFYYFAQH LWPEQNIRDS FQKVTLRRYR KCGYENLQLR
60 70 80 90 100
KGCKSVVECK QHKGDYSGLN QCLKTTLSKI FQCNKYVEVF HKISNSNRHK
110 120 130 140 150
MRHTENKHFK CKECRKTFCM LSHLTQHKRI QTRVNFYKCE AYGRAFNWSS
160 170 180 190 200
TLNKHKRIHT GEKPYKCKEC GKAFNQTSHL IRHKRIHTEE KPYKCEECGK
210 220 230 240 250
AFNQSSTLTT HNIIHTGEIP YKCEKCVRAF NQASKLTEHK LIHTGEKRYE
260 270 280 290 300
CEECGKAFNR SSKLTEHKYI HTGEKLYKCE ECGKAFNQSS TLTTHKRIHS
310 320 330 340 350
GEKPYKCEEC GKAFKQFSNL TDHKKIHTGE KPYKCEECGK AFNQLSNLTR
360 370 380 390 400
HKVIHTGEKP YKCGECGKAF NQSSALNTHK IIHTGENPHK CRESGKVFHL
410 420 430 440 450
SSKLSTCKKI HTGEKLYKCE ECGKAFNRSS TLIGHKRIHT GEKPYKCEEC
460 470 480
GKAFNQSSTL TTHKIIHTEE KQYKCDECGK AST
Length:483
Mass (Da):56,376
Last modified:April 5, 2011 - v5
Checksum:iE2729363C0E68C8E
GO

Sequence cautioni

The sequence AAA36010.1 differs from that shown. Reason: Erroneous termination at position 428. Translated as Arg.Curated
The sequence AAA58666.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAG41761.1 differs from that shown.Aberrant splicing.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401R → G in AAA58666 (PubMed:2023909).Curated
Sequence conflicti43 – 442GY → RH in AAA58666 (PubMed:2023909).Curated
Sequence conflicti131 – 1311Q → H in AAG41761 (PubMed:2505992).Curated
Sequence conflicti131 – 1311Q → H in AAA58666 (PubMed:2023909).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831C → Y.
Corresponds to variant rs3807069 [ dbSNP | Ensembl ].
VAR_057396
Natural varianti112 – 1121K → N.
Corresponds to variant rs3807068 [ dbSNP | Ensembl ].
VAR_057397

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27879 mRNA. Translation: AAG41761.1. Sequence problems.
M55422 mRNA. Translation: AAA36010.1. Sequence problems.
AC073210 Genomic DNA. No translation available.
M61867 mRNA. Translation: AAA58666.1. Different initiation.
CCDSiCCDS43593.1.
PIRiA35659.
B39384.
RefSeqiNP_056936.2. NM_015852.3.
UniGeneiHs.250693.

Genome annotation databases

EnsembliENST00000282869; ENSP00000282869; ENSG00000152926.
ENST00000620222; ENSP00000479944; ENSG00000152926.
GeneIDi51351.
KEGGihsa:51351.
UCSCiuc003ttr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M27879 mRNA. Translation: AAG41761.1. Sequence problems.
M55422 mRNA. Translation: AAA36010.1. Sequence problems.
AC073210 Genomic DNA. No translation available.
M61867 mRNA. Translation: AAA58666.1. Different initiation.
CCDSiCCDS43593.1.
PIRiA35659.
B39384.
RefSeqiNP_056936.2. NM_015852.3.
UniGeneiHs.250693.

3D structure databases

ProteinModelPortaliQ03924.
SMRiQ03924. Positions 79-481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000282869.

PTM databases

iPTMnetiQ03924.
PhosphoSiteiQ03924.

Polymorphism and mutation databases

BioMutaiZNF117.
DMDMi327478609.

Proteomic databases

PaxDbiQ03924.
PRIDEiQ03924.

Protocols and materials databases

DNASUi51351.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000282869; ENSP00000282869; ENSG00000152926.
ENST00000620222; ENSP00000479944; ENSG00000152926.
GeneIDi51351.
KEGGihsa:51351.
UCSCiuc003ttr.3. human.

Organism-specific databases

CTDi51351.
GeneCardsiZNF117.
HGNCiHGNC:12897. ZNF117.
MIMi194624. gene.
neXtProtiNX_Q03924.
PharmGKBiPA37486.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ03924.
OMAiSTLIGHK.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ03924.
TreeFamiTF342117.

Miscellaneous databases

GenomeRNAii51351.
PROiQ03924.
SOURCEiSearch...

Gene expression databases

BgeeiQ03924.
CleanExiHS_ZNF117.
ExpressionAtlasiQ03924. baseline and differential.
GenevisibleiQ03924. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 12 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human genome contains hundreds of genes coding for finger proteins of the Kruppel type."
    Bellefroid E.J., Lecocq P.J., Benhida A., Poncelet D.A., Belayew A., Martial J.A.
    DNA 8:377-387(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. "Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel."
    Kato N., Shimotohno K., VanLeeuwen D., Cohen M.
    Mol. Cell. Biol. 10:4401-4405(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The evolutionarily conserved Kruppel-associated box domain defines a subfamily of eukaryotic multifingered proteins."
    Bellefroid E.J., Poncelet D.A., Lecocq P.J., Revelant O., Martial J.A.
    Proc. Natl. Acad. Sci. U.S.A. 88:3608-3612(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-131.

Entry informationi

Entry nameiZN117_HUMAN
AccessioniPrimary (citable) accession number: Q03924
Secondary accession number(s): Q02313, Q7Z7Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: April 5, 2011
Last modified: June 8, 2016
This is version 141 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.