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Protein

Zinc finger protein 85

Gene

ZNF85

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcriptional repressor.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 168C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: ProtInc
  • metal ion binding Source: UniProtKB-KW
  • transcription corepressor activity Source: ProtInc
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 85
Alternative name(s):
Zinc finger protein HPF4
Zinc finger protein HTF1
Gene namesi
Name:ZNF85
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105750.14.
HGNCiHGNC:13160. ZNF85.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7639.
OpenTargetsiENSG00000105750.
PharmGKBiPA37733.

Polymorphism and mutation databases

BioMutaiZNF85.
DMDMi215274175.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000473981 – 595Zinc finger protein 85Add BLAST595

Proteomic databases

EPDiQ03923.
MaxQBiQ03923.
PaxDbiQ03923.
PeptideAtlasiQ03923.
PRIDEiQ03923.

PTM databases

iPTMnetiQ03923.
PhosphoSitePlusiQ03923.

Expressioni

Tissue specificityi

Widely expressed, including in testis.2 Publications

Gene expression databases

BgeeiENSG00000105750.
CleanExiHS_ZNF85.
ExpressionAtlasiQ03923. baseline and differential.
GenevisibleiQ03923. HS.

Organism-specific databases

HPAiHPA044760.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP76Q8TAP63EBI-10223330,EBI-742887

Protein-protein interaction databases

BioGridi113455. 2 interactors.
IntActiQ03923. 1 interactor.
STRINGi9606.ENSP00000329793.

Structurei

3D structure databases

ProteinModelPortaliQ03923.
SMRiQ03923.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 75KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri146 – 168C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri174 – 196C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri202 – 224C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri230 – 252C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri258 – 280C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri286 – 308C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri314 – 336C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri342 – 364C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri370 – 392C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri398 – 420C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri426 – 448C2H2-type 11; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri454 – 476C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri482 – 504C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri510 – 532C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri538 – 560C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri566 – 588C2H2-type 16PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00890000139354.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ03923.
KOiK09228.
OMAiKSFRMIS.
OrthoDBiEOG091G02KC.
PhylomeDBiQ03923.
TreeFamiTF342117.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 9 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q03923-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLTFRDVA IEFSLKEWQC LDTAQRNLYR NVMLENYRNL VFLGITVSKP
60 70 80 90 100
DLITCLEQGK EAWSMKRHEI MVAKPTVMCS HFAQDLWPEQ NIKDSFQKVT
110 120 130 140 150
LKRYGKCRHE NLPLRKGCES MDECKMHKGG CNGLNQCLTA TQSKIFQCDK
160 170 180 190 200
YVKVAHKFSN SNRHEIRHTK KKPFKCTKCG KSFGMISCLT EHSRIHTRVN
210 220 230 240 250
FYKCEECGKA FNWSSTLTKH KRIHTGEKPY KCEECGKAFN QSSNLIKHKK
260 270 280 290 300
IHTGEKPYKC EECGKTFNRF STLTTHKIIH TGEKPYKCKE CGKAFNRSST
310 320 330 340 350
LTTHRKIHTG EKPYKCEECG KAFKQSSNLT THKIIHTGEK PYKCKKCGKA
360 370 380 390 400
FNQSAHLTTH EVIHTGEKPY KCEKCGKAFN HFSHLTTHKI IHTGEKPYKC
410 420 430 440 450
KECGKAFKHS STLTKHKIIH TGEKPYKCKE CEKAFNQSSK LTEHKKIHTG
460 470 480 490 500
EKPYECEKCG KAFNQSSNLT RHKKSHTEEK PYKCEECGKG FKWPSTLTIH
510 520 530 540 550
KIIHTGEKPY KCEECGKAFN QSSKLTKHKK IHTGEKPYTC EECGKAFNQS
560 570 580 590
SNLTKHKRIH TGEKPYKCEE CDKAFKWSSV LTKHKIIHTG EKLQI
Length:595
Mass (Da):68,736
Last modified:November 25, 2008 - v3
Checksum:iF21FA8927C28DE90
GO
Isoform 2 (identifier: Q03923-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     44-76: Missing.

Note: No experimental confirmation available.
Show »
Length:562
Mass (Da):65,056
Checksum:i8CC193C2680A8A11
GO
Isoform 3 (identifier: Q03923-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-87: VMCSHFAQDLW → ESYSVTQSGMQ
     88-595: Missing.

Show »
Length:87
Mass (Da):10,088
Checksum:i254588D03599BA03
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti428C → S in AAA79179 (PubMed:9839802).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03355260K → T. Corresponds to variant dbSNP:rs7254311Ensembl.1
Natural variantiVAR_06193284Q → R2 PublicationsCorresponds to variant dbSNP:rs56321708Ensembl.1
Natural variantiVAR_061933115R → I1 PublicationCorresponds to variant dbSNP:rs56231962Ensembl.1
Natural variantiVAR_061934177T → R1 PublicationCorresponds to variant dbSNP:rs56393308Ensembl.1
Natural variantiVAR_033553184G → R1 PublicationCorresponds to variant dbSNP:rs11665978Ensembl.1
Natural variantiVAR_047515266T → A1 PublicationCorresponds to variant dbSNP:rs1063156Ensembl.1
Natural variantiVAR_033554270F → S. Corresponds to variant dbSNP:rs11670246Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03577144 – 76Missing in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_04215477 – 87VMCSHFAQDLW → ESYSVTQSGMQ in isoform 3. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_04215588 – 595Missing in isoform 3. 1 PublicationAdd BLAST508

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35376 mRNA. Translation: AAA79179.1.
AC008739 Genomic DNA. No translation available.
BC068066 mRNA. Translation: AAH68066.1.
M61866 mRNA. Translation: AAA52689.1.
M61868 mRNA. Translation: AAA58671.1.
CCDSiCCDS32977.1. [Q03923-1]
CCDS58657.1. [Q03923-3]
PIRiA39384.
C39384.
G02075.
RefSeqiNP_001243101.1. NM_001256172.1. [Q03923-3]
NP_003420.2. NM_003429.4. [Q03923-1]
UniGeneiHs.37138.

Genome annotation databases

EnsembliENST00000300540; ENSP00000300540; ENSG00000105750. [Q03923-3]
ENST00000328178; ENSP00000329793; ENSG00000105750. [Q03923-1]
ENST00000345030; ENSP00000342340; ENSG00000105750. [Q03923-2]
ENST00000613159; ENSP00000479316; ENSG00000278091. [Q03923-2]
ENST00000615320; ENSP00000483118; ENSG00000278091. [Q03923-1]
ENST00000615882; ENSP00000479120; ENSG00000278091. [Q03923-3]
GeneIDi7639.
KEGGihsa:7639.
UCSCiuc002npf.5. human. [Q03923-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZNF85_HUMAN
AccessioniPrimary (citable) accession number: Q03923
Secondary accession number(s): B9ZVP4, Q6NVI0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: November 25, 2008
Last modified: November 22, 2017
This is version 161 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families