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Protein

eRF1 methyltransferase catalytic subunit MTQ2

Gene

MTQ2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Methylates eRF1 on 'Gln-182' using S-adenosyl L-methionine as methyl donor. eRF1 needs to be complexed to eRF3 in its GTP-bound form to be efficiently methylated.3 Publications

Miscellaneous

Present with 3390 molecules/cell in log phase SD medium.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77S-adenosyl-L-methionineBy similarity1
Binding sitei122S-adenosyl-L-methionineBy similarity1

GO - Molecular functioni

  • nucleic acid binding Source: InterPro
  • protein methyltransferase activity Source: SGD
  • S-adenosylmethionine-dependent methyltransferase activity Source: SGD

GO - Biological processi

  • peptidyl-glutamine methylation Source: SGD
  • regulation of translation Source: SGD

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciYEAST:G3O-29737-MONOMER
ReactomeiR-SCE-156581 Methylation
R-SCE-72764 Eukaryotic Translation Termination

Names & Taxonomyi

Protein namesi
Recommended name:
eRF1 methyltransferase catalytic subunit MTQ2 (EC:2.1.1.-)
Short name:
eRF1 MTase catalytic subunit MTQ2
Alternative name(s):
N(5)-glutamine methyltransferase MTQ2
Gene namesi
Name:MTQ2
Synonyms:MTC6
Ordered Locus Names:YDR140W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR140W
SGDiS000002547 MTQ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458401 – 221eRF1 methyltransferase catalytic subunit MTQ2Add BLAST221

Proteomic databases

MaxQBiQ03920
PaxDbiQ03920
PRIDEiQ03920

Interactioni

Subunit structurei

Heterodimer of MTQ2-TRM112. MTQ2 is the catalytic subunit carrying the catalytic and the S-adenosyl L-methionine binding sites.

Binary interactionsi

WithEntry#Exp.IntActNotes
TRM112P537383EBI-31378,EBI-28520

Protein-protein interaction databases

BioGridi32194, 18 interactors
DIPiDIP-1755N
IntActiQ03920, 5 interactors
MINTiQ03920
STRINGi4932.YDR140W

Structurei

3D structure databases

ProteinModelPortaliQ03920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 54S-adenosyl-L-methionine bindingBy similarity5
Regioni122 – 125Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000013073
HOGENOMiHOG000219949
InParanoidiQ03920
KOiK19589
OMAiEWDDWME
OrthoDBiEOG092C52LO

Family and domain databases

InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004557 PrmC-related
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00537 hemK_rel_arch, 1 hit
PROSITEiView protein in PROSITE
PS00092 N6_MTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q03920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPTPYVKCD YDKVYEPAED SFLILDCLEK EHDFLKQKFG NRLAIVCEIG
60 70 80 90 100
SGSGIVTTFL MQNKIIPQEN SIHLAVDINP WALEATLDTA KLNSCKSSFL
110 120 130 140 150
EVIQADLNSS IRNNQVDVLI FNPPYVPAEC VPDVPGSREE ADQWLDLALL
160 170 180 190 200
GGKDGMAITD KLLRQLEQIL SPDGVAYILF CARNKPKEVI KRFVDTYKWN
210 220
VKLIETRKAG WEVLSVYSFT R
Length:221
Mass (Da):24,973
Last modified:November 1, 1996 - v1
Checksum:iC3CF6BF6A05E862D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48179 Genomic DNA Translation: CAA88222.1
AY557676 Genomic DNA Translation: AAS56002.1
BK006938 Genomic DNA Translation: DAA11983.1
PIRiS51868
RefSeqiNP_010424.3, NM_001180447.3

Genome annotation databases

EnsemblFungiiYDR140W; YDR140W; YDR140W
GeneIDi851718
KEGGisce:YDR140W

Similar proteinsi

Entry informationi

Entry nameiMTQ2_YEAST
AccessioniPrimary (citable) accession number: Q03920
Secondary accession number(s): D6VSC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

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