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Protein

F-box protein YDR131C

Gene

YDR131C

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • protein ubiquitination Source: UniProtKB-UniPathway
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-29730-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box protein YDR131C
Gene namesi
Ordered Locus Names:YDR131C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR131C.
SGDiS000002538. YDR131C.

Subcellular locationi

GO - Cellular componenti

  • SCF ubiquitin ligase complex Source: SGD
  • vacuole Source: UniProtKB-SubCell

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538041 – 556F-box protein YDR131CAdd BLAST556

Proteomic databases

MaxQBiQ03899.
PRIDEiQ03899.

Interactioni

Subunit structurei

Interacts with SKP1. Component of the probable SCF(YDR131C) complex containing CDC53, SKP1, RBX1 and YDR131C.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi32187. 52 interactors.
DIPiDIP-867N.
MINTiMINT-532082.
STRINGi4932.YDR131C.

Structurei

3D structure databases

ProteinModelPortaliQ03899.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 44F-boxPROSITE-ProRule annotationAdd BLAST44

Phylogenomic databases

GeneTreeiENSGT00530000066426.
HOGENOMiHOG000141730.
InParanoidiQ03899.
OMAiRYLTIND.
OrthoDBiEOG092C3QBR.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR032675. L_dom-like.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03899-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDKLPYEIF KQIAWRIPQE DKISLTYVCK RSYESIIPFI YQNLFLNETY
60 70 80 90 100
HINGDYDNSF GTCYWSVLNF HYIDEDDSNT KNDMSNRRLA KVKFSYFERT
110 120 130 140 150
LAESPKRLCP LINRIRCTWH LNEDVMTNVL KLLSEYGSNL KFVDQFVRSS
160 170 180 190 200
VNKGLEPLSK QLKTLTLTPP TLMPTHNSVS GSYLNKIDRL LLKCDLSRLE
210 220 230 240 250
KLSIHINALK YFKNTGSPMK IKALVLNLRP DTLNLAEYDA SDDFLKELEY
260 270 280 290 300
IDIFDASTLR QLEILSWYSR DDFPSGEEGG FDRLYVKWGL EGFWKFPNIE
310 320 330 340 350
KLSLASLVYS EFFLMNCLAV FHNLKILKLD YMGKFDFDVS LINFLSKQVC
360 370 380 390 400
GKKLQRFDIH CQLNHRLFFP MTDNPLTRLN FDGFCPCSTC KNTIHEVILK
410 420 430 440 450
KIFPETRSKL LKNPNKFQAH NFFYQMFFEN KIMPYTNIID NESPAMGWDS
460 470 480 490 500
VPIETFVRKF NENLQSTIEN TENITVNKIT REDAISLYHL YLHYLKDVFK
510 520 530 540 550
VFEQSLPNLE YLTINGIPTK IIQVDELQRC AVPLFYNNGY KSNSVYELVD

AEALFS
Length:556
Mass (Da):65,243
Last modified:November 1, 1996 - v1
Checksum:i7004D9665DAE2CEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48179 Genomic DNA. Translation: CAA88212.1.
BK006938 Genomic DNA. Translation: DAA11977.1.
PIRiS51858.
RefSeqiNP_010416.1. NM_001180439.1.

Genome annotation databases

EnsemblFungiiYDR131C; YDR131C; YDR131C.
GeneIDi851709.
KEGGisce:YDR131C.

Similar proteinsi

Entry informationi

Entry nameiYD131_YEAST
AccessioniPrimary (citable) accession number: Q03899
Secondary accession number(s): D6VSB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names