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Protein

Maintenance of telomere capping protein 5

Gene

MTC5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in telomere capping.2 Publications

GO - Biological processi

  • positive regulation of TORC1 signaling Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29727-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maintenance of telomere capping protein 5
Alternative name(s):
SEH-associated protein 3
Gene namesi
Name:MTC5
Synonyms:SEA3
Ordered Locus Names:YDR128W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR128W.
SGDiS000002535. MTC5.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of fungal-type vacuolar membrane Source: SGD
  • Seh1-associated complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002538071 – 1148Maintenance of telomere capping protein 5Add BLAST1148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei759PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03897.
PRIDEiQ03897.

PTM databases

iPTMnetiQ03897.

Interactioni

Subunit structurei

Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC13Q044915EBI-32422,EBI-16529

Protein-protein interaction databases

BioGridi32184. 100 interactors.
DIPiDIP-1825N.
IntActiQ03897. 33 interactors.
MINTiMINT-402415.

Structurei

3D structure databases

ProteinModelPortaliQ03897.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati63 – 106WD 1Add BLAST44
Repeati112 – 152WD 2Add BLAST41
Repeati156 – 195WD 3Add BLAST40
Repeati199 – 239WD 4Add BLAST41
Repeati299 – 348WD 5Add BLAST50
Domaini432 – 543RWDPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the WD repeat WDR59 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00850000132398.
InParanoidiQ03897.
KOiK20409.
OMAiDFLWRSR.
OrthoDBiEOG092C06T5.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProiIPR025651. Mtc5.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22850:SF114. PTHR22850:SF114. 4 hits.
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSSINEGPY NSPTFGKSLS LKVDGGFNAV SINPSGRDIV LASRQGLYII
60 70 80 90 100
DLDDPFTPPR WLHHITPWQV ADVQWSPHPA KPYWIVSTSN QKAIIWNLAK
110 120 130 140 150
SSSNAIEFVL HGHSRAITDI NFNPQHPDVL ATCSVDTYVH AWDMRSPHRP
160 170 180 190 200
FYSTSSWRSA ASQVKWNYKD PNVLASSHGN DIFVWDLRKG STPLCSLKGH
210 220 230 240 250
VSSVNSIDFN RFKYSEIMSS SNDGTVKFWD YSKSTTESKR TVTTNFPIWR
260 270 280 290 300
GRYLPFGEGY CIMPMVGGNN AVYLINLCDD DDSEQNKKTK LQPIYAFKGH
310 320 330 340 350
SDRVIDFLWR SRHTCDGDYD DREFQLVTWS KDCDLKLWPI SDSIYGKVNF
360 370 380 390 400
DRGKRLEEKL PDYDYCSYNK EPENRENVQK NEFRRLRENF VTTSGLKKNK
410 420 430 440 450
TNHITWLSGI RMNSATSQED LFNETKIQNL GEEVSAIGHK FPKVVFEKIS
460 470 480 490 500
VSTRELCLTL NGPWSEENPD DYIFLRISIN FPLNYPNKGD PPKFTIEENS
510 520 530 540 550
NLTMSKRQEI LSNLATIGQK YTDSNLYCLE PCIRFVLGEK VSLEDIEEGQ
560 570 580 590 600
EPLLNFDIAD HIDFEELSSL DSSYSDSQNP ENLSSQSDIE SYKEALVFPD
610 620 630 640 650
TSNQGLDFGR NLALDTTPVP NGCGSCWTAT GELFCFFANE KKPEKKQNAI
660 670 680 690 700
IKLSQKEAGV EKHPFKIEPQ VLYDKEVDSS VITAADELKA RPKRYVDTLG
710 720 730 740 750
LGGGTNGDSR TYFDDETSSD DSFDSVADDW DDILRNDIIV RTKIPILRGN
760 770 780 790 800
FKAFSSVHSE SGKTVESTKK NKNLVISKNF SSLLSDRKEL ALEYLFMDAT
810 820 830 840 850
PEGFARNNAL VAEKFDLDEI SHCWQILSDM LIDQSDYDPY TTIWNNHPMG
860 870 880 890 900
IKWFIKEAIV YFERQQNLQM LAMLCCVILS ARRKKIPARY YGQELENMEG
910 920 930 940 950
TIVFNDNESQ NTSFWKGSDA FSTRSRSSTV TPNFYGNHLR GKNIHGGDNS
960 970 980 990 1000
SIRSDDHHAR LRTHNTLNGS SKFTEPAQKQ GSRAISSSPF HSRMPDIKVE
1010 1020 1030 1040 1050
LLHDDIIEAY EQEDLLHLEV SDIPKFQTYI YQYSKLLFRW GLPLERVKIL
1060 1070 1080 1090 1100
KVSTDFRSSY SSQGIPPNNN KKSPYNGVLT HWIENNEFGE EKFLARNCNY
1110 1120 1130 1140
CDLRVTRSSF ICGNCQHVLH SSCARIWWEI GDECPSGCGC NCPEMFDA
Length:1,148
Mass (Da):130,946
Last modified:November 1, 1996 - v1
Checksum:iD6A137FB0FDE2816
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48179 Genomic DNA. Translation: CAA88209.1.
BK006938 Genomic DNA. Translation: DAA11974.1.
PIRiS51855.
RefSeqiNP_010413.3. NM_001180436.3.

Genome annotation databases

EnsemblFungiiYDR128W; YDR128W; YDR128W.
GeneIDi851706.
KEGGisce:YDR128W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48179 Genomic DNA. Translation: CAA88209.1.
BK006938 Genomic DNA. Translation: DAA11974.1.
PIRiS51855.
RefSeqiNP_010413.3. NM_001180436.3.

3D structure databases

ProteinModelPortaliQ03897.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32184. 100 interactors.
DIPiDIP-1825N.
IntActiQ03897. 33 interactors.
MINTiMINT-402415.

PTM databases

iPTMnetiQ03897.

Proteomic databases

MaxQBiQ03897.
PRIDEiQ03897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR128W; YDR128W; YDR128W.
GeneIDi851706.
KEGGisce:YDR128W.

Organism-specific databases

EuPathDBiFungiDB:YDR128W.
SGDiS000002535. MTC5.

Phylogenomic databases

GeneTreeiENSGT00850000132398.
InParanoidiQ03897.
KOiK20409.
OMAiDFLWRSR.
OrthoDBiEOG092C06T5.

Enzyme and pathway databases

BioCyciYEAST:G3O-29727-MONOMER.

Miscellaneous databases

PROiQ03897.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
3.10.110.10. 1 hit.
InterProiIPR025651. Mtc5.
IPR006575. RWD-domain.
IPR016135. UBQ-conjugating_enzyme/RWD.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22850:SF114. PTHR22850:SF114. 4 hits.
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWDR59_YEAST
AccessioniPrimary (citable) accession number: Q03897
Secondary accession number(s): D6VSB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.