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Protein

Maintenance of telomere capping protein 5

Gene

MTC5

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SEA complex which coats the vacuolar membrane and is involved in intracellular trafficking, autophagy, response to nitrogen starvation, and amino acid biogenesis. May be involved in telomere capping.2 Publications

GO - Biological processi

  • positive regulation of TORC1 signaling Source: SGD
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-29727-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maintenance of telomere capping protein 5
Alternative name(s):
SEH-associated protein 3
Gene namesi
Name:MTC5
Synonyms:SEA3
Ordered Locus Names:YDR128W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome IV

Organism-specific databases

EuPathDBiFungiDB:YDR128W.
SGDiS000002535. MTC5.

Subcellular locationi

GO - Cellular componenti

  • extrinsic component of fungal-type vacuolar membrane Source: SGD
  • Seh1-associated complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11481148Maintenance of telomere capping protein 5PRO_0000253807Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei759 – 7591PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ03897.

PTM databases

iPTMnetiQ03897.

Interactioni

Subunit structurei

Component of the SEA complex composed of at least IML1/SEA1, RTC1/SEA2, MTC5/SEA3, NPR2, NPR3, SEA4, SEC13 and SEH1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SEC13Q044915EBI-32422,EBI-16529

Protein-protein interaction databases

BioGridi32184. 100 interactions.
DIPiDIP-1825N.
IntActiQ03897. 33 interactions.
MINTiMINT-402415.

Structurei

3D structure databases

ProteinModelPortaliQ03897.
SMRiQ03897. Positions 69-343, 1096-1142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati63 – 10644WD 1Add
BLAST
Repeati112 – 15241WD 2Add
BLAST
Repeati156 – 19540WD 3Add
BLAST
Repeati199 – 23941WD 4Add
BLAST
Repeati299 – 34850WD 5Add
BLAST
Domaini432 – 543112RWDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat WDR59 family.Curated
Contains 1 RWD domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00800000124134.
InParanoidiQ03897.
OMAiDFLWRSR.
OrthoDBiEOG783N3N.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR025651. Mtc5.
IPR006575. RWD-domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22850:SF114. PTHR22850:SF114. 4 hits.
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03897-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSSINEGPY NSPTFGKSLS LKVDGGFNAV SINPSGRDIV LASRQGLYII
60 70 80 90 100
DLDDPFTPPR WLHHITPWQV ADVQWSPHPA KPYWIVSTSN QKAIIWNLAK
110 120 130 140 150
SSSNAIEFVL HGHSRAITDI NFNPQHPDVL ATCSVDTYVH AWDMRSPHRP
160 170 180 190 200
FYSTSSWRSA ASQVKWNYKD PNVLASSHGN DIFVWDLRKG STPLCSLKGH
210 220 230 240 250
VSSVNSIDFN RFKYSEIMSS SNDGTVKFWD YSKSTTESKR TVTTNFPIWR
260 270 280 290 300
GRYLPFGEGY CIMPMVGGNN AVYLINLCDD DDSEQNKKTK LQPIYAFKGH
310 320 330 340 350
SDRVIDFLWR SRHTCDGDYD DREFQLVTWS KDCDLKLWPI SDSIYGKVNF
360 370 380 390 400
DRGKRLEEKL PDYDYCSYNK EPENRENVQK NEFRRLRENF VTTSGLKKNK
410 420 430 440 450
TNHITWLSGI RMNSATSQED LFNETKIQNL GEEVSAIGHK FPKVVFEKIS
460 470 480 490 500
VSTRELCLTL NGPWSEENPD DYIFLRISIN FPLNYPNKGD PPKFTIEENS
510 520 530 540 550
NLTMSKRQEI LSNLATIGQK YTDSNLYCLE PCIRFVLGEK VSLEDIEEGQ
560 570 580 590 600
EPLLNFDIAD HIDFEELSSL DSSYSDSQNP ENLSSQSDIE SYKEALVFPD
610 620 630 640 650
TSNQGLDFGR NLALDTTPVP NGCGSCWTAT GELFCFFANE KKPEKKQNAI
660 670 680 690 700
IKLSQKEAGV EKHPFKIEPQ VLYDKEVDSS VITAADELKA RPKRYVDTLG
710 720 730 740 750
LGGGTNGDSR TYFDDETSSD DSFDSVADDW DDILRNDIIV RTKIPILRGN
760 770 780 790 800
FKAFSSVHSE SGKTVESTKK NKNLVISKNF SSLLSDRKEL ALEYLFMDAT
810 820 830 840 850
PEGFARNNAL VAEKFDLDEI SHCWQILSDM LIDQSDYDPY TTIWNNHPMG
860 870 880 890 900
IKWFIKEAIV YFERQQNLQM LAMLCCVILS ARRKKIPARY YGQELENMEG
910 920 930 940 950
TIVFNDNESQ NTSFWKGSDA FSTRSRSSTV TPNFYGNHLR GKNIHGGDNS
960 970 980 990 1000
SIRSDDHHAR LRTHNTLNGS SKFTEPAQKQ GSRAISSSPF HSRMPDIKVE
1010 1020 1030 1040 1050
LLHDDIIEAY EQEDLLHLEV SDIPKFQTYI YQYSKLLFRW GLPLERVKIL
1060 1070 1080 1090 1100
KVSTDFRSSY SSQGIPPNNN KKSPYNGVLT HWIENNEFGE EKFLARNCNY
1110 1120 1130 1140
CDLRVTRSSF ICGNCQHVLH SSCARIWWEI GDECPSGCGC NCPEMFDA
Length:1,148
Mass (Da):130,946
Last modified:November 1, 1996 - v1
Checksum:iD6A137FB0FDE2816
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48179 Genomic DNA. Translation: CAA88209.1.
BK006938 Genomic DNA. Translation: DAA11974.1.
PIRiS51855.
RefSeqiNP_010413.3. NM_001180436.3.

Genome annotation databases

EnsemblFungiiYDR128W; YDR128W; YDR128W.
GeneIDi851706.
KEGGisce:YDR128W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48179 Genomic DNA. Translation: CAA88209.1.
BK006938 Genomic DNA. Translation: DAA11974.1.
PIRiS51855.
RefSeqiNP_010413.3. NM_001180436.3.

3D structure databases

ProteinModelPortaliQ03897.
SMRiQ03897. Positions 69-343, 1096-1142.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi32184. 100 interactions.
DIPiDIP-1825N.
IntActiQ03897. 33 interactions.
MINTiMINT-402415.

PTM databases

iPTMnetiQ03897.

Proteomic databases

MaxQBiQ03897.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYDR128W; YDR128W; YDR128W.
GeneIDi851706.
KEGGisce:YDR128W.

Organism-specific databases

EuPathDBiFungiDB:YDR128W.
SGDiS000002535. MTC5.

Phylogenomic databases

GeneTreeiENSGT00800000124134.
InParanoidiQ03897.
OMAiDFLWRSR.
OrthoDBiEOG783N3N.

Enzyme and pathway databases

BioCyciYEAST:G3O-29727-MONOMER.

Miscellaneous databases

PROiQ03897.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR025651. Mtc5.
IPR006575. RWD-domain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR22850:SF114. PTHR22850:SF114. 4 hits.
SMARTiSM00591. RWD. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50908. RWD. 1 hit.
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 2 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
    Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
    , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
    Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae."
    Addinall S.G., Downey M., Yu M., Zubko M.K., Dewar J., Leake A., Hallinan J., Shaw O., James K., Wilkinson D.J., Wipat A., Durocher D., Lydall D.
    Genetics 180:2251-2266(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae."
    Dokudovskaya S., Waharte F., Schlessinger A., Pieper U., Devos D.P., Cristea I.M., Williams R., Salamero J., Chait B.T., Sali A., Field M.C., Rout M.P., Dargemont C.
    Mol. Cell. Proteomics 10:M110.006478.1-M110.006478.17(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN THE SEA COMPLEX, FUNCTION.

Entry informationi

Entry nameiWDR59_YEAST
AccessioniPrimary (citable) accession number: Q03897
Secondary accession number(s): D6VSB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 556 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.