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Protein

V-type ATPase assembly factor PKR1

Gene

PKR1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions together with the other V-type ATPase assembly factors in the endoplasmic reticulum to efficiently assemble the V-type ATPase membrane sector V0.1 Publication

Miscellaneous

Present with 5750 molecules/cell in log phase SD medium.1 Publication

GO - Biological processi

  • vacuolar proton-transporting V-type ATPase complex assembly Source: SGD

Enzyme and pathway databases

BioCyciYEAST:G3O-32816-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
V-type ATPase assembly factor PKR1
Gene namesi
Name:PKR1
Ordered Locus Names:YMR123W
ORF Names:YM8564.05
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR123W
SGDiS000004730 PKR1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 46LumenalSequence analysis5
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 122CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002032971 – 122V-type ATPase assembly factor PKR1Add BLAST122

Proteomic databases

PaxDbiQ03880
PRIDEiQ03880
TopDownProteomicsiQ03880

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SSA3P094352EBI-27252,EBI-8611

Protein-protein interaction databases

BioGridi35300, 453 interactors
DIPiDIP-4436N
IntActiQ03880, 20 interactors
MINTiQ03880
STRINGi4932.YMR123W

Structurei

3D structure databases

ProteinModelPortaliQ03880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PKR1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000248859
InParanoidiQ03880
OMAiWEKVSEN
OrthoDBiEOG092C5N5Y

Family and domain databases

InterProiView protein in InterPro
IPR013945 Pkr1
PANTHERiPTHR28251 PTHR28251, 1 hit
PfamiView protein in Pfam
PF08636 Pkr1, 1 hit

Sequencei

Sequence statusi: Complete.

Q03880-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANFFVRLWE SVFEPGTSPQ LIIATHVSFV ALLLTLIWLI YATNGNIHFY
60 70 80 90 100
ALFCISLLLW ITVIWFINEL SHVKLKDNDE LDKDANKKDD SAIKEDSEDK
110 120
QESGKSTSTA RRTQAQSRSR KA
Length:122
Mass (Da):13,962
Last modified:November 1, 1997 - v1
Checksum:i5CAA6929D55F2C40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49273 Genomic DNA Translation: CAA89272.1
AY558408 Genomic DNA Translation: AAS56734.1
BK006946 Genomic DNA Translation: DAA10020.1
PIRiS54492
RefSeqiNP_013842.1, NM_001182624.1

Genome annotation databases

EnsemblFungiiYMR123W; YMR123W; YMR123W
GeneIDi855153
KEGGisce:YMR123W

Similar proteinsi

Entry informationi

Entry nameiPKR1_YEAST
AccessioniPrimary (citable) accession number: Q03880
Secondary accession number(s): D6VZU6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health