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Reviewed, UniProtKB/Swiss-Prot Q03860 (TVP15_YEAST)

Last modified November 24, 2009. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Golgi apparatus membrane protein TVP15
Alternative name(s):
    TLG2 compartment vesicle protein 15
    TLG2-vesicle protein of 15 kDa
Gene names
Name: TVP15
Ordered Locus Names: YDR100W
OrganismSaccharomyces cerevisiae (Baker's yeast) [Complete proteome]
Taxonomic identifier4932 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

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Protein attributes

Sequence length143 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Golgi membrane protein involved in vesicular trafficking. Ref.7

Subunit structure

Interacts with TVP18. Ref.7

Subcellular location

Golgi apparatus membrane; Multi-pass membrane protein.

Miscellaneous

Present with 4540 molecules/cell in log phase SD medium. Ref.4

Sequence similarities

Belongs to the TVP15 family.

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Ontologies

Keywords
   Cellular componentGolgi apparatus
Membrane
   DomainTransmembrane
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processvesicle-mediated transport Ref.7

Inferred from genetic interaction. Source: SGD

   Cellular componentintegral to Golgi membrane Ref.5

Inferred from direct assay. Source: SGD

   Molecular functionidentical protein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 143143Golgi apparatus membrane protein TVP15
PRO_0000240392

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121 Potential
Topological domain32 – 354Lumenal Potential
Transmembrane36 – 5621 Potential
Topological domain57 – 6711Cytoplasmic Potential
Transmembrane68 – 8821 Potential
Topological domain891Lumenal Potential
Transmembrane90 – 11021 Potential
Topological domain111 – 14333Cytoplasmic Potential
Compositional bias133 – 1419Poly-Asp

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Sequences

Sequence LengthMass (Da)Tools
Q03860-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 395F700FBB14C569

FASTA14315,882
        10         20         30         40         50         60 
MSVIPPKFFK IANISIGCID IIAALSQLTY IFTNLNVFLL AVYGLALSVP IVYLEFKVPS 

        70         80         90        100        110        120 
NLYRYASFYF SFLGRGLSYI LLSLIISFGG IYNILAGMFT FILGVAFIVF HFSQFVEEPA 

       130        140 
NFRAPGSSLS IGDDDIDDDD DMI

« Hide

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References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed: 9169867] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae."
Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. expand/collapse author list , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J.
Genome Res. 17:536-543(2007) [PubMed: 17322287] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed: 14562095] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed: 14562106] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[5]"Immunoisolaton of the yeast Golgi subcompartments and characterization of a novel membrane protein, Svp26, discovered in the Sed5-containing compartments."
Inadome H., Noda Y., Adachi H., Yoda K.
Mol. Cell. Biol. 25:7696-7710(2005) [PubMed: 16107716] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"A global topology map of the Saccharomyces cerevisiae membrane proteome."
Kim H., Melen K., Oesterberg M., von Heijne G.
Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006) [PubMed: 16847258] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
[7]"Tvp38, Tvp23, Tvp18 and Tvp15: novel membrane proteins in the Tlg2-containing Golgi/endosome compartments of Saccharomyces cerevisiae."
Inadome H., Noda Y., Kamimura Y., Adachi H., Yoda K.
Exp. Cell Res. 313:688-697(2007) [PubMed: 17178117] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TVP18.
+Additional computationally mapped references.

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Cross-references

Sequence databases

Z47746 Genomic DNA. Translation: CAA87676.1.
AY558572 Genomic DNA. Translation: AAS56898.1.
PIRS51251.
RefSeqNP_010385.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

DIPDIP:2049N.
IntActQ03860. 87 interactions.
STRINGQ03860.

Genome annotation databases

EnsemblYDR100W; YDR100W; YDR100W; Saccharomyces cerevisiae. [Genome view]
GeneID851677.
KEGGsce:YDR100W.
NMPDRfig|4932.3.peg.1133.

Organism-specific databases

CYGDYDR100w.
SGDS000002507. TVP15.

Phylogenomic databases

HOGENOMQ03860.
OMAFIPSIEP
OrthoDBEOG9RR81B

Gene expression databases

ArrayExpressQ03860.
GenevestigatorQ03860.
GermOnlineYDR100W. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR013714. COPI_assoc.
[Graphical view]
PfamPF08507. COPI_assoc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio969309.

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Entry information

Entry nameTVP15_YEAST
AccessionPrimary (citable) accession number: Q03860
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 1, 1996
Last modified: November 24, 2009
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents