Q03859 (Q03859_SIVCZ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Gag polyprotein EMBL AAA91930.1
Organism	Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) EMBL AAA91930.1
Taxonomic identifier	11723 [NCBI]
Taxonomic lineage	Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group
Virus host	Pan (chimpanzees) [TaxID: 9596]

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity. SAAS SAAS012344 Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity. SAAS SAAS012344
Subcellular location	Virion By similarity SAAS SAAS000721. Virion By similarity RuleBase RU004487. Virion By similarity SAAS SAAS000721.
Post-translational modification	Specific enzymatic cleavages by the viral protease yield mature proteins By similarity. RuleBase RU004487
Sequence similarities	Contains 2 CCHC-type zinc fingers. SAAS SAAS008916

Ontologies

Keywords
Cellular component	Host cytoplasm RuleBase RU004487 SAAS SAAS000721 Host nucleus RuleBase RU004487 SAAS SAAS000721 Virion
Coding sequence diversity	Ribosomal frameshifting SAAS SAAS000721
Domain	Repeat SAAS SAAS008916 Zinc-finger SAAS SAAS010999 RuleBase RU000338
Ligand	Metal-binding RNA-binding SAAS SAAS000721 Viral nucleoprotein RuleBase RU004487 Zinc
Molecular function	Capsid protein RuleBase RU000316 SAAS SAAS000721
Gene Ontology (GO)
Biological process	viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular component	host cell cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW host cell nucleus Inferred from electronic annotation. Source: UniProtKB-KW viral capsid Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q03859 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 01DC851DB3FB7B24	FASTA	506	56,490
	10 20 30 40 50 60 MGARNSVLSG KKADELEKIR LRPGGKKKYM LKHVVWAANE LDRFGLAESL LENKEGCQKI 70 80 90 100 110 120 LSVLAPLVPT GSENLKSLYN TVCVIWCIHA EEKVKHTEEA KQIVQRHLVV ETGTAETMPK 130 140 150 160 170 180 TSRPTAPSSG RGGNYPVQQV GGNYTHLPLS PRTLNAWVKL IEEKKFGAEV VPGFQALSEG 190 200 210 220 230 240 CTPYDINQML NCVGEHQAAM QIIREIINEE AADWDLQHPQ QAPQQGQLRE PSGSDIAGTT 250 260 270 280 290 300 STVDEQIQWM YRQQNPIPVG NIYRRWIQLG LQKCVRMYNP TSILDVKQGP KEPFQSYVDR 310 320 330 340 350 360 FYKSLRAEQT DPAVKNWMTQ TLLIQNANPD CKLVLKGLGM NPTLEEMLTA CQGVGGPGQK 370 380 390 400 410 420 ARLMAEALKE ALAPGPLPFA AAQQKGPRKP IKCWNCGKEG HSARQCRTPR RQGCWKCGQM 430 440 450 460 470 480 GHVMAKCPDR QAGFLGFGPW GKKPRNFPMA QMHQGLTPTA PPEDPAVDLL KNYMQLGKQQ 490 500 RESKRKPYKE VTEDLLHLNS LFGEDQ

References

[1]	Benveniste R.E., Heidecker G., Greenwood J., Gonda M.A. Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M32741 Genomic RNA. Translation: AAA91930.1.
3D structure databases
ProteinModelPortal	Q03859.
SMR	Q03859. Positions 6-119, 146-352, 388-433.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000721. Gag_p24. IPR000071. Lentvrl_matrix_N. IPR012344. Matrix_N_HIV/RSV. IPR008916. Retrov_capsid_C. IPR008919. Retrov_capsid_N. IPR010999. Retrovr_matrix_N. IPR013084. Znf_CCH_retrovir. IPR001878. Znf_CCHC. [Graphical view]
Gene3D	G3DSA:1.10.150.90. Matrix_HIV/RSV_N. 1 hit. G3DSA:1.10.1200.30. Retrov_capsid_C. 1 hit. G3DSA:1.10.375.10. Retrov_capsid_N. 1 hit. G3DSA:4.10.60.10. Znf_CCH_retrovir. 1 hit.
Pfam	PF00540. Gag_p17. 1 hit. PF00607. Gag_p24. 1 hit. PF00098. zf-CCHC. 2 hits. [Graphical view]
PRINTS	PR00234. HIV1MATRIX.
SMART	SM00343. ZnF_C2HC. 2 hits. [Graphical view]
SUPFAM	SSF47353. Retrov_capsid_C. 1 hit. SSF47943. Retrov_capsid_N. 1 hit. SSF47836. Retrovir_matrix. 1 hit.
PROSITE	PS50158. ZF_CCHC. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q03859_SIVCZ

Accession

Primary (citable) accession number: Q03859

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)