Gag polyprotein - Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz)

Contribute

Read comments (0) or add your own

Unreviewed, UniProtKB/TrEMBL Q03859 (Q03859_SIVCZ)

Last modified May 5, 2009. Version 64. History...

Clusters with 100%, 90%, 50% identity |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Data may be missing or inconsistent due to an import problem!

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

Names and origin

Protein names	Recommended name: Gag polyprotein RuleBase RU000345V1
Organism	Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) EMBL AAA91930.1
Taxonomic identifier	11723 [NCBI]
Taxonomic lineage	Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group
Virus host	Pan (chimpanzees) [TaxID: 9596]

Protein attributes

Sequence length	506 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Capsid protein p24 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex By similarity. Spearmint SPM008916 Nucleocapsid protein p7 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers By similarity. Spearmint SPM008916
Subcellular location	Virion By similarity. RuleBase RU004487V0
Post-translational modification	Specific enzymatic cleavages by the viral protease yield mature proteins By similarity. RuleBase RU004487V0
Sequence similarities	Contains 2 CCHC-type zinc fingers. Spearmint SPM008919

Ontologies

Keywords
Cellular component	Capsid protein RuleBase RU000316V2 Spearmint SPM008919 Cytoplasm RuleBase RU004487V0 Spearmint SPM008919 Nucleus RuleBase RU004487V0 Spearmint SPM008919 Virion
Domain	Repeat Spearmint SPM008919 Zinc-finger RuleBase RU004486V0
Ligand	Metal-binding RNA-binding Spearmint SPM008919 Viral nucleoprotein RuleBase RU004487V0 Spearmint SPM008919 Zinc
Gene Ontology (GO)
Biological process	viral reproduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW viral capsid Inferred from electronic annotation. Source: InterPro
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural molecule activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

Q03859-1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 01DC851DB3FB7B24
Show »

506

56,490

        10         20         30         40         50         60 
MGARNSVLSG KKADELEKIR LRPGGKKKYM LKHVVWAANE LDRFGLAESL LENKEGCQKI 

        70         80         90        100        110        120 
LSVLAPLVPT GSENLKSLYN TVCVIWCIHA EEKVKHTEEA KQIVQRHLVV ETGTAETMPK 

       130        140        150        160        170        180 
TSRPTAPSSG RGGNYPVQQV GGNYTHLPLS PRTLNAWVKL IEEKKFGAEV VPGFQALSEG 

       190        200        210        220        230        240 
CTPYDINQML NCVGEHQAAM QIIREIINEE AADWDLQHPQ QAPQQGQLRE PSGSDIAGTT 

       250        260        270        280        290        300 
STVDEQIQWM YRQQNPIPVG NIYRRWIQLG LQKCVRMYNP TSILDVKQGP KEPFQSYVDR 

       310        320        330        340        350        360 
FYKSLRAEQT DPAVKNWMTQ TLLIQNANPD CKLVLKGLGM NPTLEEMLTA CQGVGGPGQK 

       370        380        390        400        410        420 
ARLMAEALKE ALAPGPLPFA AAQQKGPRKP IKCWNCGKEG HSARQCRTPR RQGCWKCGQM 

       430        440        450        460        470        480 
GHVMAKCPDR QAGFLGFGPW GKKPRNFPMA QMHQGLTPTA PPEDPAVDLL KNYMQLGKQQ 

       490        500 
RESKRKPYKE VTEDLLHLNS LFGEDQ

References

[1]	Benveniste R.E., Heidecker G., Greenwood J., Gonda M.A. Submitted (AUG-1990) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Crystal structure of SIV matrix antigen and implications for virus assembly." Rao Z., Belyaev A.S., Fry E., Roy P., Jones I.M., Stuart D.I. Nature 378:743-747(1995) [PubMed: 7501025] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-135.

Cross-references

Sequence databases

M32741 Genomic RNA. Translation: AAA91930.1.

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ED1	X-ray	2.10	A	1-135	[»]

SMR

Q03859. Positions 146-352.

ModBase

Family and domain databases

InterPro

IPR000721. Gag_p24.
IPR000071. Lentvrl_matrix_N.
IPR012344. Matrix_HIV/RSV_N.
IPR008916. Retrov_capsid_C.
IPR008919. Retrov_capsid_N.
IPR013084. Znf_CCH_retrovir.
IPR001878. Znf_CCHC.
[Graphical view]

Gene3D

G3DSA:1.10.150.90. Matrix_HIV/RSV_N. 1 hit.
G3DSA:1.10.1200.30. Retrov_capsid_C. 1 hit.
G3DSA:1.10.375.10. Retrov_capsid_N. 1 hit.
G3DSA:4.10.60.10. Znf_CCH_retrovir. 1 hit.

Pfam

PF00540. Gag_p17. 1 hit.
PF00607. Gag_p24. 1 hit.
PF00098. zf-CCHC. 2 hits.
[Graphical view]

PRINTS

PR00234. HIV1MATRIX.

SMART

SM00343. ZnF_C2HC. 2 hits.
[Graphical view]

PROSITE

PS50158. ZF_CCHC. 2 hits.
[Graphical view]

ProtoNet

Entry information

Entry name

Q03859_SIVCZ

Accession

Primary (citable) accession number: Q03859

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	May 5, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information