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Protein

Homeobox even-skipped homolog protein 2

Gene

EVX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi188 – 24760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox even-skipped homolog protein 2
Alternative name(s):
EVX-2
Gene namesi
Name:EVX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:3507. EVX2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27920.

Polymorphism and mutation databases

BioMutaiEVX2.
DMDMi12231013.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Homeobox even-skipped homolog protein 2PRO_0000048872Add
BLAST

Proteomic databases

PaxDbiQ03828.
PRIDEiQ03828.

Expressioni

Developmental stagei

Expressed during early embryogenesis and neurogenesis in a biphasic manner.

Gene expression databases

BgeeiENSG00000174279.
CleanExiHS_EVX2.

Organism-specific databases

HPAiHPA041576.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312385.

Structurei

3D structure databases

ProteinModelPortaliQ03828.
SMRiQ03828. Positions 190-246.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 3018Poly-Ala
Compositional biasi304 – 3085Poly-Ala
Compositional biasi346 – 3516Poly-Ala
Compositional biasi356 – 37015Poly-AlaAdd
BLAST
Compositional biasi373 – 3786Poly-Ala
Compositional biasi398 – 40811Poly-AlaAdd
BLAST
Compositional biasi413 – 43422Poly-GlyAdd
BLAST

Sequence similaritiesi

Belongs to the even-skipped homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0844. Eukaryota.
ENOG4111RMB. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000231897.
HOVERGENiHBG005620.
InParanoidiQ03828.
KOiK09320.
OMAiHPGLYQT.
OrthoDBiEOG091G0JVN.
PhylomeDBiQ03828.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMERIRKEMI LMERGLHSPT AGKRFSNLSN SAGNAVLEAL ENSQHPARLS
60 70 80 90 100
PRLPSAPLHS ALGELPAKGK FEIDTLFNLQ HTGSESTVSS EISSAAESRK
110 120 130 140 150
KPGHYSEAAA EADMSSDVEV GCSALRSPGG LGAAQLKENN GKGYAESGSA
160 170 180 190 200
AGTTTSASGS GLGSLHGGSG GSGGSAALGG SGSGADQVRR YRTAFTREQI
210 220 230 240 250
ARLEKEFYRE NYVSRPRRCE LAAALNLPET TIKVWFQNRR MKDKRQRLAM
260 270 280 290 300
SWPHPADPSF YTYMMTHAAA TGSLPYPFHS HVPLHYYPHV GVTAAAAAAA
310 320 330 340 350
ASGAAAAASS PFATSIRPLD TFRALSHPYS RPELLCSFRH PGLYQAPAAA
360 370 380 390 400
AGLNSAASAA AAAAAAAAAA SSAAAAGAPP SGGSAPCSCL SCHSSQSAAA
410 420 430 440 450
AAAAAAAALG SRGGGGGGGG GGGGGGGGAG AGGGSDFGCS AAAPRSESGF
460 470
LPYSAAVLSK TAVSPPDQRD EAPLTR
Length:476
Mass (Da):47,800
Last modified:January 11, 2001 - v2
Checksum:i6AA99041BA151C3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009336 Genomic DNA. No translation available.
M59983, M59982 Genomic DNA. Translation: AAA52414.1.
CCDSiCCDS33333.1.
PIRiA39065.
RefSeqiNP_001073927.1. NM_001080458.1.
UniGeneiHs.452341.

Genome annotation databases

EnsembliENST00000308618; ENSP00000312385; ENSG00000174279.
GeneIDi344191.
KEGGihsa:344191.
UCSCiuc010zeu.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009336 Genomic DNA. No translation available.
M59983, M59982 Genomic DNA. Translation: AAA52414.1.
CCDSiCCDS33333.1.
PIRiA39065.
RefSeqiNP_001073927.1. NM_001080458.1.
UniGeneiHs.452341.

3D structure databases

ProteinModelPortaliQ03828.
SMRiQ03828. Positions 190-246.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312385.

Polymorphism and mutation databases

BioMutaiEVX2.
DMDMi12231013.

Proteomic databases

PaxDbiQ03828.
PRIDEiQ03828.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308618; ENSP00000312385; ENSG00000174279.
GeneIDi344191.
KEGGihsa:344191.
UCSCiuc010zeu.3. human.

Organism-specific databases

CTDi344191.
GeneCardsiEVX2.
HGNCiHGNC:3507. EVX2.
HPAiHPA041576.
MIMi142991. gene.
neXtProtiNX_Q03828.
PharmGKBiPA27920.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0844. Eukaryota.
ENOG4111RMB. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000231897.
HOVERGENiHBG005620.
InParanoidiQ03828.
KOiK09320.
OMAiHPGLYQT.
OrthoDBiEOG091G0JVN.
PhylomeDBiQ03828.
TreeFamiTF315938.

Miscellaneous databases

GenomeRNAii344191.
PROiQ03828.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174279.
CleanExiHS_EVX2.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEVX2_HUMAN
AccessioniPrimary (citable) accession number: Q03828
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 11, 2001
Last modified: September 7, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.