ID   MSS11_YEAST             Reviewed;         758 AA.
AC   Q03825; D6VZY6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   27-MAR-2024, entry version 145.
DE   RecName: Full=Transcription activator MSS11;
DE   AltName: Full=Multicopy suppressor of STA genes protein 11;
GN   Name=MSS11; OrderedLocusNames=YMR164C; ORFNames=YM8520.13C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=9342405; DOI=10.1007/s002940050275;
RA   Webber A.L., Lambrechts M.G., Pretorius I.S.;
RT   "MSS11, a novel yeast gene involved in the regulation of starch
RT   metabolism.";
RL   Curr. Genet. 32:260-266(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   FUNCTION.
RX   PubMed=9832522; DOI=10.1093/genetics/150.4.1443;
RA   Lorenz M.C., Heitman J.;
RT   "Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae
RT   identified through multicopy suppressor analysis in ammonium permease
RT   mutant strains.";
RL   Genetics 150:1443-1457(1998).
RN   [5]
RP   FUNCTION.
RX   PubMed=10515942; DOI=10.1128/jb.181.20.6497-6508.1999;
RA   Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.;
RT   "Divergent regulation of the evolutionarily closely related promoters of
RT   the Saccharomyces cerevisiae STA2 and MUC1 genes.";
RL   J. Bacteriol. 181:6497-6508(1999).
RN   [6]
RP   FUNCTION.
RX   PubMed=9987114; DOI=10.1046/j.1365-2958.1999.01151.x;
RA   Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.;
RT   "Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction
RT   pathway downstream of Mep2p regulating invasive growth and pseudohyphal
RT   differentiation in Saccharomyces cerevisiae.";
RL   Mol. Microbiol. 31:103-116(1999).
RN   [7]
RP   FUNCTION.
RX   PubMed=14523573; DOI=10.1007/s00294-003-0447-7;
RA   Kim T.S., Ahn J.Y., Yoon J.H., Kang H.S.;
RT   "STA10 repression of STA gene expression is caused by a defective
RT   activator, flo8, in Saccharomyces cerevisiae.";
RL   Curr. Genet. 44:261-267(2003).
RN   [8]
RP   FUNCTION, AND MUTAGENESIS OF 133-PHE-LEU-134; 137-TRP-TRP-138;
RP   140-ILE-PHE-141 AND 144-LEU-PHE-145.
RX   PubMed=12492858; DOI=10.1046/j.1365-2958.2003.03247.x;
RA   Gagiano M., Bester M.C., van Dyk D., Franken J., Bauer F.F.,
RA   Pretorius I.S.;
RT   "Mss11p is a transcription factor regulating pseudohyphal differentiation,
RT   invasive growth and starch metabolism in Saccharomyces cerevisiae in
RT   response to nutrient availability.";
RL   Mol. Microbiol. 47:119-134(2003).
RN   [9]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [10]
RP   FUNCTION, DNA-BINDING, AND INTERACTION WITH FLO8; STE12 AND TEC1.
RX   PubMed=15485921; DOI=10.1128/mcb.24.21.9542-9556.2004;
RA   Kim T.S., Kim H.Y., Yoon J.H., Kang H.S.;
RT   "Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-
RT   mediated activation of STA1 expression.";
RL   Mol. Cell. Biol. 24:9542-9556(2004).
RN   [11]
RP   FUNCTION.
RX   PubMed=15466424; DOI=10.1534/genetics.104.033704;
RA   van Dyk D., Pretorius I.S., Bauer F.F.;
RT   "Mss11p is a central element of the regulatory network that controls FLO11
RT   expression and invasive growth in Saccharomyces cerevisiae.";
RL   Genetics 169:91-106(2005).
RN   [12]
RP   FUNCTION.
RX   PubMed=16568252; DOI=10.1007/s00294-006-0068-z;
RA   Bester M.C., Pretorius I.S., Bauer F.F.;
RT   "The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+
RT   -dependent flocculation by Flo8p and Mss11p.";
RL   Curr. Genet. 49:375-383(2006).
RN   [13]
RP   FUNCTION.
RX   PubMed=18001350; DOI=10.1111/j.1365-2958.2007.06014.x;
RA   Fichtner L., Schulze F., Braus G.H.;
RT   "Differential Flo8p-dependent regulation of FLO1 and FLO11 for cell-cell
RT   and cell-substrate adherence of S.cerevisiae S288c.";
RL   Mol. Microbiol. 66:1276-1289(2007).
RN   [14]
RP   FUNCTION.
RX   PubMed=18202364; DOI=10.1534/genetics.107.081315;
RA   Barrales R.R., Jimenez J., Ibeas J.I.;
RT   "Identification of novel activation mechanisms for FLO11 regulation in
RT   Saccharomyces cerevisiae.";
RL   Genetics 178:145-156(2008).
RN   [15]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- FUNCTION: Transcription factor that regulates pseudohyphal
CC       differentiation, invasive growth, floculation, adhesion and starch
CC       metabolism in response to nutrient availability.
CC       {ECO:0000269|PubMed:10515942, ECO:0000269|PubMed:12492858,
CC       ECO:0000269|PubMed:14523573, ECO:0000269|PubMed:15466424,
CC       ECO:0000269|PubMed:15485921, ECO:0000269|PubMed:16568252,
CC       ECO:0000269|PubMed:18001350, ECO:0000269|PubMed:18202364,
CC       ECO:0000269|PubMed:9342405, ECO:0000269|PubMed:9832522,
CC       ECO:0000269|PubMed:9987114}.
CC   -!- SUBUNIT: Interacts with FLO8, STE12 and TEC1.
CC       {ECO:0000269|PubMed:15485921}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC       {ECO:0000269|PubMed:14562095}.
CC   -!- SIMILARITY: Belongs to the MSS11 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z49705; CAA89800.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10060.1; -; Genomic_DNA.
DR   PIR; S54522; S54522.
DR   RefSeq; NP_013887.1; NM_001182668.1.
DR   AlphaFoldDB; Q03825; -.
DR   BioGRID; 35342; 78.
DR   IntAct; Q03825; 1.
DR   STRING; 4932.YMR164C; -.
DR   GlyGen; Q03825; 3 sites, 1 O-linked glycan (3 sites).
DR   iPTMnet; Q03825; -.
DR   PaxDb; 4932-YMR164C; -.
DR   PeptideAtlas; Q03825; -.
DR   EnsemblFungi; YMR164C_mRNA; YMR164C; YMR164C.
DR   GeneID; 855200; -.
DR   KEGG; sce:YMR164C; -.
DR   AGR; SGD:S000004774; -.
DR   SGD; S000004774; MSS11.
DR   VEuPathDB; FungiDB:YMR164C; -.
DR   eggNOG; ENOG502S549; Eukaryota.
DR   HOGENOM; CLU_368109_0_0_1; -.
DR   InParanoid; Q03825; -.
DR   OMA; FLIEWWN; -.
DR   OrthoDB; 1978411at2759; -.
DR   BioCyc; YEAST:G3O-32854-MONOMER; -.
DR   BioGRID-ORCS; 855200; 6 hits in 10 CRISPR screens.
DR   PRO; PR:Q03825; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q03825; Protein.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IC:SGD.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR   InterPro; IPR006594; LisH.
DR   PANTHER; PTHR45093; TRANSCRIPTION ACTIVATOR MSS11; 1.
DR   PANTHER; PTHR45093:SF2; TRANSCRIPTION ACTIVATOR MSS11; 1.
DR   Pfam; PF08513; LisH; 1.
DR   SMART; SM00667; LisH; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   1: Evidence at protein level;
KW   Activator; Cytoplasm; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..758
FT                   /note="Transcription activator MSS11"
FT                   /id="PRO_0000203315"
FT   DOMAIN          51..83
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          191..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          268..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          587..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        587..669
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MUTAGEN         133..134
FT                   /note="FL->GA: Reduces ability to activate transcription
FT                   and to induce invasive growth."
FT                   /evidence="ECO:0000269|PubMed:12492858"
FT   MUTAGEN         137..138
FT                   /note="WW->GA: Reduces ability to activate transcription
FT                   and to induce invasive growth."
FT                   /evidence="ECO:0000269|PubMed:12492858"
FT   MUTAGEN         140..141
FT                   /note="IF->GA: Reduces ability to activate transcription
FT                   and to induce invasive growth."
FT                   /evidence="ECO:0000269|PubMed:12492858"
FT   MUTAGEN         144..145
FT                   /note="LF->GA: Reduces ability to activate transcription
FT                   and to induce invasive growth."
FT                   /evidence="ECO:0000269|PubMed:12492858"
SQ   SEQUENCE   758 AA;  85050 MW;  BA05BFC754D9294B CRC64;
     MDNTTNINTN ERSSNTDFSS APNIKGLNSH TQLQFDADSR VFVSDVMAKN SKQLLYAHIY
     NYLIKNNYWN SAAKFLSEAD LPLSRINGSA SGGKTSLNAS LKQGLMDIAS KGDIVSEDGL
     LPSKMLMDAN DTFLLEWWEI FQSLFNGDLE SGYQQDHNPL RERIIPILPA NSKSNMPSHF
     SNLPPNVIPP TQNSFPVSEE SFRPNGDGSN FNLNDPTNRN VSERFLSRTS GVYDKQNSAN
     FAPDTAINSD IAGQQYATIN LHKHFNDLQS PAQPQQSSQQ QIQQPQHQPQ HQPQQQQQQQ
     QQQQQQQQQQ QQQQQQQQQQ QQQHQQQQQT PYPIVNPQMV PHIPSENSHS TGLMPSVPPT
     NQQFNAQTQS SMFSDQQRFF QYQLHHQNQG QAPSFQQSQS GRFDDMNAMK MFFQQQALQQ
     NSLQQNLGNQ NYQSNTRNNT AEETTPTNDN NANGNSLLQE HIRARFNKMK TIPQQMKNQS
     TVANPVVSDI TSQQQYMHMM MQRMAANQQL QNSAFPPDTN RIAPANNTMP LQPGNMGSPV
     IENPGMRQTN PSGQNPMINM QPLYQNVSSA MHAFAPQQQF HLPQHYKTNT SVPQNDSTSV
     FPLPNNNNNN NNNNNNNNNN NSNNSNNNNN NNNNNNNSNN TPTVSQPSSK CTSSSSTTPN
     ITTTIQPKRK QRVGKTKTKE SRKVAAAQKV MKSKKLEQNG DSAATNFINV TPKDSGGKGT
     VKVQNSNSQQ QLNGSFSMDT ETFDIFNIGD FSPDLMDS
//