SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q03825

- MSS11_YEAST

UniProt

Q03825 - MSS11_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Transcription activator MSS11
Gene
MSS11, YMR164C, YM8520.13C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.11 Publications

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD

GO - Biological processi

  1. biofilm formation Source: SGD
  2. positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  3. positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  4. positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  5. positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32854-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator MSS11
Alternative name(s):
Multicopy suppressor of STA genes protein 11
Gene namesi
Name:MSS11
Ordered Locus Names:YMR164C
ORF Names:YM8520.13C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR164c.
SGDiS000004774. MSS11.

Subcellular locationi

Cytoplasm. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi133 – 1342FL → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
Mutagenesisi137 – 1382WW → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
Mutagenesisi140 – 1412IF → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
Mutagenesisi144 – 1452LF → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Transcription activator MSS11
PRO_0000203315Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ03825.

Interactioni

Subunit structurei

Interacts with FLO8, STE12 and TEC1.1 Publication

Protein-protein interaction databases

BioGridi35342. 46 interactions.
IntActiQ03825. 1 interaction.
MINTiMINT-4498215.
STRINGi4932.YMR164C.

Structurei

3D structure databases

ProteinModelPortaliQ03825.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 8333LisH
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 32940Poly-Gln
Add
BLAST
Compositional biasi605 – 63733Poly-Asn
Add
BLAST
Compositional biasi653 – 6564Poly-Ser

Sequence similaritiesi

Belongs to the MSS11 family.
Contains 1 LisH domain.

Phylogenomic databases

eggNOGiNOG12793.
KOiK06053.
OMAiRIAPANN.
OrthoDBiEOG7KWSX4.

Family and domain databases

InterProiIPR006594. LisH_dimerisation.
IPR013720. LisH_dimerisation_subgr.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03825-1 [UniParc]FASTAAdd to Basket

« Hide

MDNTTNINTN ERSSNTDFSS APNIKGLNSH TQLQFDADSR VFVSDVMAKN    50
SKQLLYAHIY NYLIKNNYWN SAAKFLSEAD LPLSRINGSA SGGKTSLNAS 100
LKQGLMDIAS KGDIVSEDGL LPSKMLMDAN DTFLLEWWEI FQSLFNGDLE 150
SGYQQDHNPL RERIIPILPA NSKSNMPSHF SNLPPNVIPP TQNSFPVSEE 200
SFRPNGDGSN FNLNDPTNRN VSERFLSRTS GVYDKQNSAN FAPDTAINSD 250
IAGQQYATIN LHKHFNDLQS PAQPQQSSQQ QIQQPQHQPQ HQPQQQQQQQ 300
QQQQQQQQQQ QQQQQQQQQQ QQQHQQQQQT PYPIVNPQMV PHIPSENSHS 350
TGLMPSVPPT NQQFNAQTQS SMFSDQQRFF QYQLHHQNQG QAPSFQQSQS 400
GRFDDMNAMK MFFQQQALQQ NSLQQNLGNQ NYQSNTRNNT AEETTPTNDN 450
NANGNSLLQE HIRARFNKMK TIPQQMKNQS TVANPVVSDI TSQQQYMHMM 500
MQRMAANQQL QNSAFPPDTN RIAPANNTMP LQPGNMGSPV IENPGMRQTN 550
PSGQNPMINM QPLYQNVSSA MHAFAPQQQF HLPQHYKTNT SVPQNDSTSV 600
FPLPNNNNNN NNNNNNNNNN NSNNSNNNNN NNNNNNNSNN TPTVSQPSSK 650
CTSSSSTTPN ITTTIQPKRK QRVGKTKTKE SRKVAAAQKV MKSKKLEQNG 700
DSAATNFINV TPKDSGGKGT VKVQNSNSQQ QLNGSFSMDT ETFDIFNIGD 750
FSPDLMDS 758
Length:758
Mass (Da):85,050
Last modified:November 1, 1997 - v1
Checksum:iBA05BFC754D9294B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49705 Genomic DNA. Translation: CAA89800.1.
BK006946 Genomic DNA. Translation: DAA10060.1.
PIRiS54522.
RefSeqiNP_013887.1. NM_001182668.1.

Genome annotation databases

EnsemblFungiiYMR164C; YMR164C; YMR164C.
GeneIDi855200.
KEGGisce:YMR164C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49705 Genomic DNA. Translation: CAA89800.1 .
BK006946 Genomic DNA. Translation: DAA10060.1 .
PIRi S54522.
RefSeqi NP_013887.1. NM_001182668.1.

3D structure databases

ProteinModelPortali Q03825.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35342. 46 interactions.
IntActi Q03825. 1 interaction.
MINTi MINT-4498215.
STRINGi 4932.YMR164C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR164C ; YMR164C ; YMR164C .
GeneIDi 855200.
KEGGi sce:YMR164C.

Organism-specific databases

CYGDi YMR164c.
SGDi S000004774. MSS11.

Phylogenomic databases

eggNOGi NOG12793.
KOi K06053.
OMAi RIAPANN.
OrthoDBi EOG7KWSX4.

Enzyme and pathway databases

BioCyci YEAST:G3O-32854-MONOMER.

Miscellaneous databases

NextBioi 978684.

Gene expression databases

Genevestigatori Q03825.

Family and domain databases

InterProi IPR006594. LisH_dimerisation.
IPR013720. LisH_dimerisation_subgr.
[Graphical view ]
Pfami PF08513. LisH. 1 hit.
[Graphical view ]
SMARTi SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MSS11, a novel yeast gene involved in the regulation of starch metabolism."
    Webber A.L., Lambrechts M.G., Pretorius I.S.
    Curr. Genet. 32:260-266(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains."
    Lorenz M.C., Heitman J.
    Genetics 150:1443-1457(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Divergent regulation of the evolutionarily closely related promoters of the Saccharomyces cerevisiae STA2 and MUC1 genes."
    Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
    J. Bacteriol. 181:6497-6508(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae."
    Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
    Mol. Microbiol. 31:103-116(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae."
    Kim T.S., Ahn J.Y., Yoon J.H., Kang H.S.
    Curr. Genet. 44:261-267(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Mss11p is a transcription factor regulating pseudohyphal differentiation, invasive growth and starch metabolism in Saccharomyces cerevisiae in response to nutrient availability."
    Gagiano M., Bester M.C., van Dyk D., Franken J., Bauer F.F., Pretorius I.S.
    Mol. Microbiol. 47:119-134(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 133-PHE-LEU-134; 137-TRP-TRP-138; 140-ILE-PHE-141 AND 144-LEU-PHE-145.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. "Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression."
    Kim T.S., Kim H.Y., Yoon J.H., Kang H.S.
    Mol. Cell. Biol. 24:9542-9556(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH FLO8; STE12 AND TEC1.
  11. "Mss11p is a central element of the regulatory network that controls FLO11 expression and invasive growth in Saccharomyces cerevisiae."
    van Dyk D., Pretorius I.S., Bauer F.F.
    Genetics 169:91-106(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by Flo8p and Mss11p."
    Bester M.C., Pretorius I.S., Bauer F.F.
    Curr. Genet. 49:375-383(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Differential Flo8p-dependent regulation of FLO1 and FLO11 for cell-cell and cell-substrate adherence of S.cerevisiae S288c."
    Fichtner L., Schulze F., Braus G.H.
    Mol. Microbiol. 66:1276-1289(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae."
    Barrales R.R., Jimenez J., Ibeas J.I.
    Genetics 178:145-156(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSS11_YEAST
AccessioniPrimary (citable) accession number: Q03825
Secondary accession number(s): D6VZY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi