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Q03825

- MSS11_YEAST

UniProt

Q03825 - MSS11_YEAST

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Protein

Transcription activator MSS11

Gene

MSS11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.11 Publications

GO - Molecular functioni

  1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD

GO - Biological processi

  1. biofilm formation Source: SGD
  2. positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  3. positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  4. positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter Source: SGD
  5. positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-32854-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator MSS11
Alternative name(s):
Multicopy suppressor of STA genes protein 11
Gene namesi
Name:MSS11
Ordered Locus Names:YMR164C
ORF Names:YM8520.13C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR164c.
SGDiS000004774. MSS11.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi133 – 1342FL → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
Mutagenesisi137 – 1382WW → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
Mutagenesisi140 – 1412IF → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
Mutagenesisi144 – 1452LF → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Transcription activator MSS11PRO_0000203315Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ03825.

Interactioni

Subunit structurei

Interacts with FLO8, STE12 and TEC1.1 Publication

Protein-protein interaction databases

BioGridi35342. 46 interactions.
IntActiQ03825. 1 interaction.
MINTiMINT-4498215.
STRINGi4932.YMR164C.

Structurei

3D structure databases

ProteinModelPortaliQ03825.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 8333LisHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 32940Poly-GlnAdd
BLAST
Compositional biasi605 – 63733Poly-AsnAdd
BLAST
Compositional biasi653 – 6564Poly-Ser

Sequence similaritiesi

Belongs to the MSS11 family.Curated
Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG12793.
InParanoidiQ03825.
KOiK06053.
OMAiRIAPANN.
OrthoDBiEOG7KWSX4.

Family and domain databases

InterProiIPR006594. LisH_dimerisation.
IPR013720. LisH_dimerisation_subgr.
[Graphical view]
PfamiPF08513. LisH. 1 hit.
[Graphical view]
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q03825-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNTTNINTN ERSSNTDFSS APNIKGLNSH TQLQFDADSR VFVSDVMAKN
60 70 80 90 100
SKQLLYAHIY NYLIKNNYWN SAAKFLSEAD LPLSRINGSA SGGKTSLNAS
110 120 130 140 150
LKQGLMDIAS KGDIVSEDGL LPSKMLMDAN DTFLLEWWEI FQSLFNGDLE
160 170 180 190 200
SGYQQDHNPL RERIIPILPA NSKSNMPSHF SNLPPNVIPP TQNSFPVSEE
210 220 230 240 250
SFRPNGDGSN FNLNDPTNRN VSERFLSRTS GVYDKQNSAN FAPDTAINSD
260 270 280 290 300
IAGQQYATIN LHKHFNDLQS PAQPQQSSQQ QIQQPQHQPQ HQPQQQQQQQ
310 320 330 340 350
QQQQQQQQQQ QQQQQQQQQQ QQQHQQQQQT PYPIVNPQMV PHIPSENSHS
360 370 380 390 400
TGLMPSVPPT NQQFNAQTQS SMFSDQQRFF QYQLHHQNQG QAPSFQQSQS
410 420 430 440 450
GRFDDMNAMK MFFQQQALQQ NSLQQNLGNQ NYQSNTRNNT AEETTPTNDN
460 470 480 490 500
NANGNSLLQE HIRARFNKMK TIPQQMKNQS TVANPVVSDI TSQQQYMHMM
510 520 530 540 550
MQRMAANQQL QNSAFPPDTN RIAPANNTMP LQPGNMGSPV IENPGMRQTN
560 570 580 590 600
PSGQNPMINM QPLYQNVSSA MHAFAPQQQF HLPQHYKTNT SVPQNDSTSV
610 620 630 640 650
FPLPNNNNNN NNNNNNNNNN NSNNSNNNNN NNNNNNNSNN TPTVSQPSSK
660 670 680 690 700
CTSSSSTTPN ITTTIQPKRK QRVGKTKTKE SRKVAAAQKV MKSKKLEQNG
710 720 730 740 750
DSAATNFINV TPKDSGGKGT VKVQNSNSQQ QLNGSFSMDT ETFDIFNIGD

FSPDLMDS
Length:758
Mass (Da):85,050
Last modified:November 1, 1997 - v1
Checksum:iBA05BFC754D9294B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA. Translation: CAA89800.1.
BK006946 Genomic DNA. Translation: DAA10060.1.
PIRiS54522.
RefSeqiNP_013887.1. NM_001182668.1.

Genome annotation databases

EnsemblFungiiYMR164C; YMR164C; YMR164C.
GeneIDi855200.
KEGGisce:YMR164C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA. Translation: CAA89800.1 .
BK006946 Genomic DNA. Translation: DAA10060.1 .
PIRi S54522.
RefSeqi NP_013887.1. NM_001182668.1.

3D structure databases

ProteinModelPortali Q03825.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35342. 46 interactions.
IntActi Q03825. 1 interaction.
MINTi MINT-4498215.
STRINGi 4932.YMR164C.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR164C ; YMR164C ; YMR164C .
GeneIDi 855200.
KEGGi sce:YMR164C.

Organism-specific databases

CYGDi YMR164c.
SGDi S000004774. MSS11.

Phylogenomic databases

eggNOGi NOG12793.
InParanoidi Q03825.
KOi K06053.
OMAi RIAPANN.
OrthoDBi EOG7KWSX4.

Enzyme and pathway databases

BioCyci YEAST:G3O-32854-MONOMER.

Miscellaneous databases

NextBioi 978684.

Gene expression databases

Genevestigatori Q03825.

Family and domain databases

InterProi IPR006594. LisH_dimerisation.
IPR013720. LisH_dimerisation_subgr.
[Graphical view ]
Pfami PF08513. LisH. 1 hit.
[Graphical view ]
SMARTi SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "MSS11, a novel yeast gene involved in the regulation of starch metabolism."
    Webber A.L., Lambrechts M.G., Pretorius I.S.
    Curr. Genet. 32:260-266(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains."
    Lorenz M.C., Heitman J.
    Genetics 150:1443-1457(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Divergent regulation of the evolutionarily closely related promoters of the Saccharomyces cerevisiae STA2 and MUC1 genes."
    Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
    J. Bacteriol. 181:6497-6508(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  6. "Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae."
    Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
    Mol. Microbiol. 31:103-116(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae."
    Kim T.S., Ahn J.Y., Yoon J.H., Kang H.S.
    Curr. Genet. 44:261-267(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Mss11p is a transcription factor regulating pseudohyphal differentiation, invasive growth and starch metabolism in Saccharomyces cerevisiae in response to nutrient availability."
    Gagiano M., Bester M.C., van Dyk D., Franken J., Bauer F.F., Pretorius I.S.
    Mol. Microbiol. 47:119-134(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 133-PHE-LEU-134; 137-TRP-TRP-138; 140-ILE-PHE-141 AND 144-LEU-PHE-145.
  9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  10. "Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression."
    Kim T.S., Kim H.Y., Yoon J.H., Kang H.S.
    Mol. Cell. Biol. 24:9542-9556(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH FLO8; STE12 AND TEC1.
  11. "Mss11p is a central element of the regulatory network that controls FLO11 expression and invasive growth in Saccharomyces cerevisiae."
    van Dyk D., Pretorius I.S., Bauer F.F.
    Genetics 169:91-106(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by Flo8p and Mss11p."
    Bester M.C., Pretorius I.S., Bauer F.F.
    Curr. Genet. 49:375-383(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Differential Flo8p-dependent regulation of FLO1 and FLO11 for cell-cell and cell-substrate adherence of S.cerevisiae S288c."
    Fichtner L., Schulze F., Braus G.H.
    Mol. Microbiol. 66:1276-1289(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  14. "Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae."
    Barrales R.R., Jimenez J., Ibeas J.I.
    Genetics 178:145-156(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMSS11_YEAST
AccessioniPrimary (citable) accession number: Q03825
Secondary accession number(s): D6VZY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3