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Q03825

- MSS11_YEAST

UniProt

Q03825 - MSS11_YEAST

Protein

Transcription activator MSS11

Gene

MSS11

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability.11 Publications

    GO - Molecular functioni

    1. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: SGD

    GO - Biological processi

    1. biofilm formation Source: SGD
    2. positive regulation of flocculation via cell wall protein-carbohydrate interaction by positive regulation of transcription from RNA polymerase II promoter Source: SGD
    3. positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter Source: SGD
    4. positive regulation of pseudohyphal growth by positive regulation of transcription from RNA polymerase II promoter Source: SGD
    5. positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter Source: SGD

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32854-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription activator MSS11
    Alternative name(s):
    Multicopy suppressor of STA genes protein 11
    Gene namesi
    Name:MSS11
    Ordered Locus Names:YMR164C
    ORF Names:YM8520.13C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR164c.
    SGDiS000004774. MSS11.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: SGD

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi133 – 1342FL → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
    Mutagenesisi137 – 1382WW → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
    Mutagenesisi140 – 1412IF → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication
    Mutagenesisi144 – 1452LF → GA: Reduces ability to activate transcription and to induce invasive growth. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758Transcription activator MSS11PRO_0000203315Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ03825.

    Interactioni

    Subunit structurei

    Interacts with FLO8, STE12 and TEC1.1 Publication

    Protein-protein interaction databases

    BioGridi35342. 46 interactions.
    IntActiQ03825. 1 interaction.
    MINTiMINT-4498215.
    STRINGi4932.YMR164C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03825.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 8333LisHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi290 – 32940Poly-GlnAdd
    BLAST
    Compositional biasi605 – 63733Poly-AsnAdd
    BLAST
    Compositional biasi653 – 6564Poly-Ser

    Sequence similaritiesi

    Belongs to the MSS11 family.Curated
    Contains 1 LisH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG12793.
    KOiK06053.
    OMAiRIAPANN.
    OrthoDBiEOG7KWSX4.

    Family and domain databases

    InterProiIPR006594. LisH_dimerisation.
    IPR013720. LisH_dimerisation_subgr.
    [Graphical view]
    PfamiPF08513. LisH. 1 hit.
    [Graphical view]
    SMARTiSM00667. LisH. 1 hit.
    [Graphical view]
    PROSITEiPS50896. LISH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q03825-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNTTNINTN ERSSNTDFSS APNIKGLNSH TQLQFDADSR VFVSDVMAKN    50
    SKQLLYAHIY NYLIKNNYWN SAAKFLSEAD LPLSRINGSA SGGKTSLNAS 100
    LKQGLMDIAS KGDIVSEDGL LPSKMLMDAN DTFLLEWWEI FQSLFNGDLE 150
    SGYQQDHNPL RERIIPILPA NSKSNMPSHF SNLPPNVIPP TQNSFPVSEE 200
    SFRPNGDGSN FNLNDPTNRN VSERFLSRTS GVYDKQNSAN FAPDTAINSD 250
    IAGQQYATIN LHKHFNDLQS PAQPQQSSQQ QIQQPQHQPQ HQPQQQQQQQ 300
    QQQQQQQQQQ QQQQQQQQQQ QQQHQQQQQT PYPIVNPQMV PHIPSENSHS 350
    TGLMPSVPPT NQQFNAQTQS SMFSDQQRFF QYQLHHQNQG QAPSFQQSQS 400
    GRFDDMNAMK MFFQQQALQQ NSLQQNLGNQ NYQSNTRNNT AEETTPTNDN 450
    NANGNSLLQE HIRARFNKMK TIPQQMKNQS TVANPVVSDI TSQQQYMHMM 500
    MQRMAANQQL QNSAFPPDTN RIAPANNTMP LQPGNMGSPV IENPGMRQTN 550
    PSGQNPMINM QPLYQNVSSA MHAFAPQQQF HLPQHYKTNT SVPQNDSTSV 600
    FPLPNNNNNN NNNNNNNNNN NSNNSNNNNN NNNNNNNSNN TPTVSQPSSK 650
    CTSSSSTTPN ITTTIQPKRK QRVGKTKTKE SRKVAAAQKV MKSKKLEQNG 700
    DSAATNFINV TPKDSGGKGT VKVQNSNSQQ QLNGSFSMDT ETFDIFNIGD 750
    FSPDLMDS 758
    Length:758
    Mass (Da):85,050
    Last modified:November 1, 1997 - v1
    Checksum:iBA05BFC754D9294B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49705 Genomic DNA. Translation: CAA89800.1.
    BK006946 Genomic DNA. Translation: DAA10060.1.
    PIRiS54522.
    RefSeqiNP_013887.1. NM_001182668.1.

    Genome annotation databases

    EnsemblFungiiYMR164C; YMR164C; YMR164C.
    GeneIDi855200.
    KEGGisce:YMR164C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49705 Genomic DNA. Translation: CAA89800.1 .
    BK006946 Genomic DNA. Translation: DAA10060.1 .
    PIRi S54522.
    RefSeqi NP_013887.1. NM_001182668.1.

    3D structure databases

    ProteinModelPortali Q03825.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35342. 46 interactions.
    IntActi Q03825. 1 interaction.
    MINTi MINT-4498215.
    STRINGi 4932.YMR164C.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR164C ; YMR164C ; YMR164C .
    GeneIDi 855200.
    KEGGi sce:YMR164C.

    Organism-specific databases

    CYGDi YMR164c.
    SGDi S000004774. MSS11.

    Phylogenomic databases

    eggNOGi NOG12793.
    KOi K06053.
    OMAi RIAPANN.
    OrthoDBi EOG7KWSX4.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32854-MONOMER.

    Miscellaneous databases

    NextBioi 978684.

    Gene expression databases

    Genevestigatori Q03825.

    Family and domain databases

    InterProi IPR006594. LisH_dimerisation.
    IPR013720. LisH_dimerisation_subgr.
    [Graphical view ]
    Pfami PF08513. LisH. 1 hit.
    [Graphical view ]
    SMARTi SM00667. LisH. 1 hit.
    [Graphical view ]
    PROSITEi PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "MSS11, a novel yeast gene involved in the regulation of starch metabolism."
      Webber A.L., Lambrechts M.G., Pretorius I.S.
      Curr. Genet. 32:260-266(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains."
      Lorenz M.C., Heitman J.
      Genetics 150:1443-1457(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Divergent regulation of the evolutionarily closely related promoters of the Saccharomyces cerevisiae STA2 and MUC1 genes."
      Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
      J. Bacteriol. 181:6497-6508(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae."
      Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
      Mol. Microbiol. 31:103-116(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae."
      Kim T.S., Ahn J.Y., Yoon J.H., Kang H.S.
      Curr. Genet. 44:261-267(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    8. "Mss11p is a transcription factor regulating pseudohyphal differentiation, invasive growth and starch metabolism in Saccharomyces cerevisiae in response to nutrient availability."
      Gagiano M., Bester M.C., van Dyk D., Franken J., Bauer F.F., Pretorius I.S.
      Mol. Microbiol. 47:119-134(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF 133-PHE-LEU-134; 137-TRP-TRP-138; 140-ILE-PHE-141 AND 144-LEU-PHE-145.
    9. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    10. "Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression."
      Kim T.S., Kim H.Y., Yoon J.H., Kang H.S.
      Mol. Cell. Biol. 24:9542-9556(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH FLO8; STE12 AND TEC1.
    11. "Mss11p is a central element of the regulatory network that controls FLO11 expression and invasive growth in Saccharomyces cerevisiae."
      van Dyk D., Pretorius I.S., Bauer F.F.
      Genetics 169:91-106(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by Flo8p and Mss11p."
      Bester M.C., Pretorius I.S., Bauer F.F.
      Curr. Genet. 49:375-383(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. "Differential Flo8p-dependent regulation of FLO1 and FLO11 for cell-cell and cell-substrate adherence of S.cerevisiae S288c."
      Fichtner L., Schulze F., Braus G.H.
      Mol. Microbiol. 66:1276-1289(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae."
      Barrales R.R., Jimenez J., Ibeas J.I.
      Genetics 178:145-156(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMSS11_YEAST
    AccessioniPrimary (citable) accession number: Q03825
    Secondary accession number(s): D6VZY6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3