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Q03825 (MSS11_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcription activator MSS11
Alternative name(s):
Multicopy suppressor of STA genes protein 11
Gene names
Name:MSS11
Ordered Locus Names:YMR164C
ORF Names:YM8520.13C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length758 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability. Ref.1 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14

Subunit structure

Interacts with FLO8, STE12 and TEC1. Ref.10

Subcellular location

Cytoplasm. Nucleus Ref.9.

Sequence similarities

Belongs to the MSS11 family.

Contains 1 LisH domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 758758Transcription activator MSS11
PRO_0000203315

Regions

Domain51 – 8333LisH
Compositional bias290 – 32940Poly-Gln
Compositional bias605 – 63733Poly-Asn
Compositional bias653 – 6564Poly-Ser

Experimental info

Mutagenesis133 – 1342FL → GA: Reduces ability to activate transcription and to induce invasive growth. Ref.8
Mutagenesis137 – 1382WW → GA: Reduces ability to activate transcription and to induce invasive growth. Ref.8
Mutagenesis140 – 1412IF → GA: Reduces ability to activate transcription and to induce invasive growth. Ref.8
Mutagenesis144 – 1452LF → GA: Reduces ability to activate transcription and to induce invasive growth. Ref.8

Sequences

Sequence LengthMass (Da)Tools
Q03825 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: BA05BFC754D9294B

FASTA75885,050
        10         20         30         40         50         60 
MDNTTNINTN ERSSNTDFSS APNIKGLNSH TQLQFDADSR VFVSDVMAKN SKQLLYAHIY 

        70         80         90        100        110        120 
NYLIKNNYWN SAAKFLSEAD LPLSRINGSA SGGKTSLNAS LKQGLMDIAS KGDIVSEDGL 

       130        140        150        160        170        180 
LPSKMLMDAN DTFLLEWWEI FQSLFNGDLE SGYQQDHNPL RERIIPILPA NSKSNMPSHF 

       190        200        210        220        230        240 
SNLPPNVIPP TQNSFPVSEE SFRPNGDGSN FNLNDPTNRN VSERFLSRTS GVYDKQNSAN 

       250        260        270        280        290        300 
FAPDTAINSD IAGQQYATIN LHKHFNDLQS PAQPQQSSQQ QIQQPQHQPQ HQPQQQQQQQ 

       310        320        330        340        350        360 
QQQQQQQQQQ QQQQQQQQQQ QQQHQQQQQT PYPIVNPQMV PHIPSENSHS TGLMPSVPPT 

       370        380        390        400        410        420 
NQQFNAQTQS SMFSDQQRFF QYQLHHQNQG QAPSFQQSQS GRFDDMNAMK MFFQQQALQQ 

       430        440        450        460        470        480 
NSLQQNLGNQ NYQSNTRNNT AEETTPTNDN NANGNSLLQE HIRARFNKMK TIPQQMKNQS 

       490        500        510        520        530        540 
TVANPVVSDI TSQQQYMHMM MQRMAANQQL QNSAFPPDTN RIAPANNTMP LQPGNMGSPV 

       550        560        570        580        590        600 
IENPGMRQTN PSGQNPMINM QPLYQNVSSA MHAFAPQQQF HLPQHYKTNT SVPQNDSTSV 

       610        620        630        640        650        660 
FPLPNNNNNN NNNNNNNNNN NSNNSNNNNN NNNNNNNSNN TPTVSQPSSK CTSSSSTTPN 

       670        680        690        700        710        720 
ITTTIQPKRK QRVGKTKTKE SRKVAAAQKV MKSKKLEQNG DSAATNFINV TPKDSGGKGT 

       730        740        750 
VKVQNSNSQQ QLNGSFSMDT ETFDIFNIGD FSPDLMDS 

« Hide

References

« Hide 'large scale' references
[1]"MSS11, a novel yeast gene involved in the regulation of starch metabolism."
Webber A.L., Lambrechts M.G., Pretorius I.S.
Curr. Genet. 32:260-266(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII."
Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T., Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P. expand/collapse author list , Skelton J., Walsh S.V., Whitehead S., Barrell B.G.
Nature 387:90-93(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]"The reference genome sequence of Saccharomyces cerevisiae: Then and now."
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R., Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S., Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.
G3 (Bethesda) 4:389-398(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains."
Lorenz M.C., Heitman J.
Genetics 150:1443-1457(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Divergent regulation of the evolutionarily closely related promoters of the Saccharomyces cerevisiae STA2 and MUC1 genes."
Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
J. Bacteriol. 181:6497-6508(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[6]"Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae."
Gagiano M., van Dyk D., Bauer F.F., Lambrechts M.G., Pretorius I.S.
Mol. Microbiol. 31:103-116(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae."
Kim T.S., Ahn J.Y., Yoon J.H., Kang H.S.
Curr. Genet. 44:261-267(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[8]"Mss11p is a transcription factor regulating pseudohyphal differentiation, invasive growth and starch metabolism in Saccharomyces cerevisiae in response to nutrient availability."
Gagiano M., Bester M.C., van Dyk D., Franken J., Bauer F.F., Pretorius I.S.
Mol. Microbiol. 47:119-134(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTAGENESIS OF 133-PHE-LEU-134; 137-TRP-TRP-138; 140-ILE-PHE-141 AND 144-LEU-PHE-145.
[9]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[10]"Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression."
Kim T.S., Kim H.Y., Yoon J.H., Kang H.S.
Mol. Cell. Biol. 24:9542-9556(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DNA-BINDING, INTERACTION WITH FLO8; STE12 AND TEC1.
[11]"Mss11p is a central element of the regulatory network that controls FLO11 expression and invasive growth in Saccharomyces cerevisiae."
van Dyk D., Pretorius I.S., Bauer F.F.
Genetics 169:91-106(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[12]"The regulation of Saccharomyces cerevisiae FLO gene expression and Ca2+ -dependent flocculation by Flo8p and Mss11p."
Bester M.C., Pretorius I.S., Bauer F.F.
Curr. Genet. 49:375-383(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[13]"Differential Flo8p-dependent regulation of FLO1 and FLO11 for cell-cell and cell-substrate adherence of S.cerevisiae S288c."
Fichtner L., Schulze F., Braus G.H.
Mol. Microbiol. 66:1276-1289(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[14]"Identification of novel activation mechanisms for FLO11 regulation in Saccharomyces cerevisiae."
Barrales R.R., Jimenez J., Ibeas J.I.
Genetics 178:145-156(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[15]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z49705 Genomic DNA. Translation: CAA89800.1.
BK006946 Genomic DNA. Translation: DAA10060.1.
PIRS54522.
RefSeqNP_013887.1. NM_001182668.1.

3D structure databases

ProteinModelPortalQ03825.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid35342. 46 interactions.
IntActQ03825. 1 interaction.
MINTMINT-4498215.
STRING4932.YMR164C.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYMR164C; YMR164C; YMR164C.
GeneID855200.
KEGGsce:YMR164C.

Organism-specific databases

CYGDYMR164c.
SGDS000004774. MSS11.

Phylogenomic databases

eggNOGNOG12793.
KOK06053.
OMARIAPANN.
OrthoDBEOG7KWSX4.

Enzyme and pathway databases

BioCycYEAST:G3O-32854-MONOMER.

Gene expression databases

GenevestigatorQ03825.

Family and domain databases

InterProIPR006594. LisH_dimerisation.
IPR013720. LisH_dimerisation_subgr.
[Graphical view]
PfamPF08513. LisH. 1 hit.
[Graphical view]
SMARTSM00667. LisH. 1 hit.
[Graphical view]
PROSITEPS50896. LISH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio978684.

Entry information

Entry nameMSS11_YEAST
AccessionPrimary (citable) accession number: Q03825
Secondary accession number(s): D6VZY6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XIII

Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families