ID   INP2_YEAST              Reviewed;         705 AA.
AC   Q03824; D6VZY5;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   27-MAR-2024, entry version 151.
DE   RecName: Full=Inheritance of peroxisomes protein 2;
GN   Name=INP2; OrderedLocusNames=YMR163C; ORFNames=YM8520.12C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S., Jagels K.,
RA   Lye G., Moule S., Odell C., Pearson D., Rajandream M.A., Rice P.,
RA   Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH MYO2.
RX   PubMed=16678774; DOI=10.1016/j.devcel.2006.04.012;
RA   Fagarasanu A., Fagarasanu M., Eitzen G.A., Aitchison J.D.,
RA   Rachubinski R.A.;
RT   "The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor
RT   for the myosin V motor Myo2p of Saccharomyces cerevisiae.";
RL   Dev. Cell 10:587-600(2006).
CC   -!- FUNCTION: Required for peroxisome inheritance. Acts as the peroxisome-
CC       specific receptor for the myosin V motor MYO2.
CC       {ECO:0000269|PubMed:16678774}.
CC   -!- SUBUNIT: Interacts with MYO2. {ECO:0000269|PubMed:16678774}.
CC   -!- INTERACTION:
CC       Q03824; P19524: MYO2; NbExp=3; IntAct=EBI-27354, EBI-11659;
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:14562095,
CC       ECO:0000269|PubMed:16678774}; Single-pass membrane protein
CC       {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:16678774}.
CC   -!- MISCELLANEOUS: Present with 736 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the INP2 family. {ECO:0000305}.
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DR   EMBL; Z49705; CAA89799.1; -; Genomic_DNA.
DR   EMBL; BK006946; DAA10059.1; -; Genomic_DNA.
DR   PIR; S54521; S54521.
DR   RefSeq; NP_013886.1; NM_001182667.1.
DR   PDB; 6IXR; X-ray; 2.85 A; B=531-543.
DR   PDBsum; 6IXR; -.
DR   AlphaFoldDB; Q03824; -.
DR   SMR; Q03824; -.
DR   BioGRID; 35340; 80.
DR   DIP; DIP-1673N; -.
DR   IntAct; Q03824; 5.
DR   MINT; Q03824; -.
DR   STRING; 4932.YMR163C; -.
DR   GlyCosmos; Q03824; 7 sites, No reported glycans.
DR   GlyGen; Q03824; 7 sites.
DR   iPTMnet; Q03824; -.
DR   PaxDb; 4932-YMR163C; -.
DR   PeptideAtlas; Q03824; -.
DR   EnsemblFungi; YMR163C_mRNA; YMR163C; YMR163C.
DR   GeneID; 855198; -.
DR   KEGG; sce:YMR163C; -.
DR   AGR; SGD:S000004773; -.
DR   SGD; S000004773; INP2.
DR   VEuPathDB; FungiDB:YMR163C; -.
DR   eggNOG; ENOG502QR0E; Eukaryota.
DR   HOGENOM; CLU_024345_0_0_1; -.
DR   InParanoid; Q03824; -.
DR   OMA; FQYTIIA; -.
DR   OrthoDB; 2039935at2759; -.
DR   BioCyc; YEAST:G3O-32853-MONOMER; -.
DR   BioGRID-ORCS; 855198; 0 hits in 10 CRISPR screens.
DR   PRO; PR:Q03824; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   RNAct; Q03824; Protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0005778; C:peroxisomal membrane; IDA:SGD.
DR   GO; GO:0043495; F:protein-membrane adaptor activity; IMP:SGD.
DR   GO; GO:0045033; P:peroxisome inheritance; IMP:SGD.
DR   InterPro; IPR026235; INP2.
DR   PRINTS; PR02104; INPROXISOME2.
PE   1: Evidence at protein level;
KW   3D-structure; Glycoprotein; Membrane; Peroxisome; Receptor;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..705
FT                   /note="Inheritance of peroxisomes protein 2"
FT                   /id="PRO_0000203314"
FT   TRANSMEM        215..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        275
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        343
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        344
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        379
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        517
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        569
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        574
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   705 AA;  81467 MW;  E4F2A4D205A98F66 CRC64;
     MTTNSRPSAL QAPGLQIFSM LKSSEEDGFM SSSLTLDSDN IIGVTENNRQ EFYSTWRKPS
     LLSSRSVLHE YSPTIVGSND CTFSPITVGK TTKFFNWDDI ISRIFMQQPF GVTHQFFEEF
     RYSIITSHFL NDMNHYRLSL HLDQSIMNFH KSSTLLKNVP PKSVPFMATK YGKLAVAEDK
     KLYFRQNFNY LSMIITSYRV LTQLKKYCRK KNSPGLKRVV ILILVAVYLS IQQEYFRRHL
     ICYKTLLKVR KVLESLQQVD VMIHKYHLRF KEIKNHSFIS RVSLISIADE HSSVIKELLV
     FSSDALFYKL KSIIPDIVIF SDTSELSKYC ELYGIDVPNL YYNNTTTVKD LDGKLYRLKL
     LKKFMLCCLL SLDMTGNENL SNVNMRNALN KIFPDYMARV QLKKKYNPIG TFQNIVSLLR
     GLHSLLSTVL VSLNDHKQIL YAFPEETSTN TGCERANVCS FSKNDKLFQA LNYLKMIENN
     LLAIDIRNGI TENDRNIIED KLEELITFWK TSKICGNISR IQKVSPTNTI NHGFHLDILK
     GRKSPRSSSV QGLSLERKVD FIDVAESVND SFENDTELEE YEDYDCQEEC SAGSRQNHRV
     DFIGKDSCRK PDFKQLSDNE LRRKLDERIL KLAQENREGR ERLRTAKSFE LLRKAQASMS
     VKFGFQKPLR DDAFLESRPL SKCKVSSEET IPFLYELKGL LGNDS
//