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Q03824

- INP2_YEAST

UniProt

Q03824 - INP2_YEAST

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Protein

Inheritance of peroxisomes protein 2

Gene
INP2, YMR163C, YM8520.12C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for peroxisome inheritance. Acts as the peroxisome-specific receptor for the myosin V motor MYO2.1 Publication

GO - Molecular functioni

  1. protein anchor Source: SGD
  2. protein binding Source: IntAct

GO - Biological processi

  1. peroxisome inheritance Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciYEAST:G3O-32853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inheritance of peroxisomes protein 2
Gene namesi
Name:INP2
Ordered Locus Names:YMR163C
ORF Names:YM8520.12C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR163c.
SGDiS000004773. INP2.

Subcellular locationi

Peroxisome membrane; Single-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei215 – 23117Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Inheritance of peroxisomes protein 2PRO_0000203314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi275 – 2751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi343 – 3431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi344 – 3441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi379 – 3791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi517 – 5171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi574 – 5741N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ03824.

Expressioni

Gene expression databases

GenevestigatoriQ03824.

Interactioni

Subunit structurei

Interacts with MYO2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYO2P195243EBI-27354,EBI-11659
PEX19Q074183EBI-27354,EBI-292

Protein-protein interaction databases

BioGridi35340. 13 interactions.
DIPiDIP-1673N.
IntActiQ03824. 5 interactions.
MINTiMINT-385667.
STRINGi4932.YMR163C.

Structurei

3D structure databases

ProteinModelPortaliQ03824.

Family & Domainsi

Sequence similaritiesi

Belongs to the INP2 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40466.
OMAiITHIASM.
OrthoDBiEOG7FJHBG.

Family and domain databases

InterProiIPR026235. INP2.
IPR026859. Myosin-bd.
[Graphical view]
PfamiPF12632. Vezatin. 1 hit.
[Graphical view]
PRINTSiPR02104. INPROXISOME2.

Sequencei

Sequence statusi: Complete.

Q03824-1 [UniParc]FASTAAdd to Basket

« Hide

MTTNSRPSAL QAPGLQIFSM LKSSEEDGFM SSSLTLDSDN IIGVTENNRQ    50
EFYSTWRKPS LLSSRSVLHE YSPTIVGSND CTFSPITVGK TTKFFNWDDI 100
ISRIFMQQPF GVTHQFFEEF RYSIITSHFL NDMNHYRLSL HLDQSIMNFH 150
KSSTLLKNVP PKSVPFMATK YGKLAVAEDK KLYFRQNFNY LSMIITSYRV 200
LTQLKKYCRK KNSPGLKRVV ILILVAVYLS IQQEYFRRHL ICYKTLLKVR 250
KVLESLQQVD VMIHKYHLRF KEIKNHSFIS RVSLISIADE HSSVIKELLV 300
FSSDALFYKL KSIIPDIVIF SDTSELSKYC ELYGIDVPNL YYNNTTTVKD 350
LDGKLYRLKL LKKFMLCCLL SLDMTGNENL SNVNMRNALN KIFPDYMARV 400
QLKKKYNPIG TFQNIVSLLR GLHSLLSTVL VSLNDHKQIL YAFPEETSTN 450
TGCERANVCS FSKNDKLFQA LNYLKMIENN LLAIDIRNGI TENDRNIIED 500
KLEELITFWK TSKICGNISR IQKVSPTNTI NHGFHLDILK GRKSPRSSSV 550
QGLSLERKVD FIDVAESVND SFENDTELEE YEDYDCQEEC SAGSRQNHRV 600
DFIGKDSCRK PDFKQLSDNE LRRKLDERIL KLAQENREGR ERLRTAKSFE 650
LLRKAQASMS VKFGFQKPLR DDAFLESRPL SKCKVSSEET IPFLYELKGL 700
LGNDS 705
Length:705
Mass (Da):81,467
Last modified:November 1, 1997 - v1
Checksum:iE4F2A4D205A98F66
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49705 Genomic DNA. Translation: CAA89799.1.
BK006946 Genomic DNA. Translation: DAA10059.1.
PIRiS54521.
RefSeqiNP_013886.1. NM_001182667.1.

Genome annotation databases

EnsemblFungiiYMR163C; YMR163C; YMR163C.
GeneIDi855198.
KEGGisce:YMR163C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49705 Genomic DNA. Translation: CAA89799.1 .
BK006946 Genomic DNA. Translation: DAA10059.1 .
PIRi S54521.
RefSeqi NP_013886.1. NM_001182667.1.

3D structure databases

ProteinModelPortali Q03824.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35340. 13 interactions.
DIPi DIP-1673N.
IntActi Q03824. 5 interactions.
MINTi MINT-385667.
STRINGi 4932.YMR163C.

Proteomic databases

PaxDbi Q03824.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR163C ; YMR163C ; YMR163C .
GeneIDi 855198.
KEGGi sce:YMR163C.

Organism-specific databases

CYGDi YMR163c.
SGDi S000004773. INP2.

Phylogenomic databases

eggNOGi NOG40466.
OMAi ITHIASM.
OrthoDBi EOG7FJHBG.

Enzyme and pathway databases

BioCyci YEAST:G3O-32853-MONOMER.

Miscellaneous databases

NextBioi 978679.

Gene expression databases

Genevestigatori Q03824.

Family and domain databases

InterProi IPR026235. INP2.
IPR026859. Myosin-bd.
[Graphical view ]
Pfami PF12632. Vezatin. 1 hit.
[Graphical view ]
PRINTSi PR02104. INPROXISOME2.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae."
    Fagarasanu A., Fagarasanu M., Eitzen G.A., Aitchison J.D., Rachubinski R.A.
    Dev. Cell 10:587-600(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MYO2.

Entry informationi

Entry nameiINP2_YEAST
AccessioniPrimary (citable) accession number: Q03824
Secondary accession number(s): D6VZY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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