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Q03824

- INP2_YEAST

UniProt

Q03824 - INP2_YEAST

Protein

Inheritance of peroxisomes protein 2

Gene

INP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Required for peroxisome inheritance. Acts as the peroxisome-specific receptor for the myosin V motor MYO2.1 Publication

    GO - Molecular functioni

    1. protein anchor Source: SGD
    2. protein binding Source: IntAct

    GO - Biological processi

    1. peroxisome inheritance Source: SGD

    Keywords - Molecular functioni

    Receptor

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32853-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inheritance of peroxisomes protein 2
    Gene namesi
    Name:INP2
    Ordered Locus Names:YMR163C
    ORF Names:YM8520.12C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    CYGDiYMR163c.
    SGDiS000004773. INP2.

    Subcellular locationi

    Peroxisome membrane 2 Publications; Single-pass membrane protein 2 Publications

    GO - Cellular componenti

    1. integral component of peroxisomal membrane Source: SGD

    Keywords - Cellular componenti

    Membrane, Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 705705Inheritance of peroxisomes protein 2PRO_0000203314Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ03824.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03824.

    Interactioni

    Subunit structurei

    Interacts with MYO2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYO2P195243EBI-27354,EBI-11659
    PEX19Q074183EBI-27354,EBI-292

    Protein-protein interaction databases

    BioGridi35340. 13 interactions.
    DIPiDIP-1673N.
    IntActiQ03824. 5 interactions.
    MINTiMINT-385667.
    STRINGi4932.YMR163C.

    Structurei

    3D structure databases

    ProteinModelPortaliQ03824.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei215 – 23117HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the INP2 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40466.
    OMAiITHIASM.
    OrthoDBiEOG7FJHBG.

    Family and domain databases

    InterProiIPR026235. INP2.
    IPR026859. Myosin-bd.
    [Graphical view]
    PfamiPF12632. Vezatin. 1 hit.
    [Graphical view]
    PRINTSiPR02104. INPROXISOME2.

    Sequencei

    Sequence statusi: Complete.

    Q03824-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTNSRPSAL QAPGLQIFSM LKSSEEDGFM SSSLTLDSDN IIGVTENNRQ    50
    EFYSTWRKPS LLSSRSVLHE YSPTIVGSND CTFSPITVGK TTKFFNWDDI 100
    ISRIFMQQPF GVTHQFFEEF RYSIITSHFL NDMNHYRLSL HLDQSIMNFH 150
    KSSTLLKNVP PKSVPFMATK YGKLAVAEDK KLYFRQNFNY LSMIITSYRV 200
    LTQLKKYCRK KNSPGLKRVV ILILVAVYLS IQQEYFRRHL ICYKTLLKVR 250
    KVLESLQQVD VMIHKYHLRF KEIKNHSFIS RVSLISIADE HSSVIKELLV 300
    FSSDALFYKL KSIIPDIVIF SDTSELSKYC ELYGIDVPNL YYNNTTTVKD 350
    LDGKLYRLKL LKKFMLCCLL SLDMTGNENL SNVNMRNALN KIFPDYMARV 400
    QLKKKYNPIG TFQNIVSLLR GLHSLLSTVL VSLNDHKQIL YAFPEETSTN 450
    TGCERANVCS FSKNDKLFQA LNYLKMIENN LLAIDIRNGI TENDRNIIED 500
    KLEELITFWK TSKICGNISR IQKVSPTNTI NHGFHLDILK GRKSPRSSSV 550
    QGLSLERKVD FIDVAESVND SFENDTELEE YEDYDCQEEC SAGSRQNHRV 600
    DFIGKDSCRK PDFKQLSDNE LRRKLDERIL KLAQENREGR ERLRTAKSFE 650
    LLRKAQASMS VKFGFQKPLR DDAFLESRPL SKCKVSSEET IPFLYELKGL 700
    LGNDS 705
    Length:705
    Mass (Da):81,467
    Last modified:November 1, 1997 - v1
    Checksum:iE4F2A4D205A98F66
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49705 Genomic DNA. Translation: CAA89799.1.
    BK006946 Genomic DNA. Translation: DAA10059.1.
    PIRiS54521.
    RefSeqiNP_013886.1. NM_001182667.1.

    Genome annotation databases

    EnsemblFungiiYMR163C; YMR163C; YMR163C.
    GeneIDi855198.
    KEGGisce:YMR163C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49705 Genomic DNA. Translation: CAA89799.1 .
    BK006946 Genomic DNA. Translation: DAA10059.1 .
    PIRi S54521.
    RefSeqi NP_013886.1. NM_001182667.1.

    3D structure databases

    ProteinModelPortali Q03824.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35340. 13 interactions.
    DIPi DIP-1673N.
    IntActi Q03824. 5 interactions.
    MINTi MINT-385667.
    STRINGi 4932.YMR163C.

    Proteomic databases

    PaxDbi Q03824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR163C ; YMR163C ; YMR163C .
    GeneIDi 855198.
    KEGGi sce:YMR163C.

    Organism-specific databases

    CYGDi YMR163c.
    SGDi S000004773. INP2.

    Phylogenomic databases

    eggNOGi NOG40466.
    OMAi ITHIASM.
    OrthoDBi EOG7FJHBG.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32853-MONOMER.

    Miscellaneous databases

    NextBioi 978679.

    Gene expression databases

    Genevestigatori Q03824.

    Family and domain databases

    InterProi IPR026235. INP2.
    IPR026859. Myosin-bd.
    [Graphical view ]
    Pfami PF12632. Vezatin. 1 hit.
    [Graphical view ]
    PRINTSi PR02104. INPROXISOME2.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    5. "The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae."
      Fagarasanu A., Fagarasanu M., Eitzen G.A., Aitchison J.D., Rachubinski R.A.
      Dev. Cell 10:587-600(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MYO2.

    Entry informationi

    Entry nameiINP2_YEAST
    AccessioniPrimary (citable) accession number: Q03824
    Secondary accession number(s): D6VZY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 736 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    3. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3