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Protein

Inheritance of peroxisomes protein 2

Gene

INP2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for peroxisome inheritance. Acts as the peroxisome-specific receptor for the myosin V motor MYO2.1 Publication

GO - Molecular functioni

  1. protein anchor Source: SGD

GO - Biological processi

  1. peroxisome inheritance Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciYEAST:G3O-32853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Inheritance of peroxisomes protein 2
Gene namesi
Name:INP2
Ordered Locus Names:YMR163C
ORF Names:YM8520.12C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

CYGDiYMR163c.
SGDiS000004773. INP2.

Subcellular locationi

Peroxisome membrane 2 Publications; Single-pass membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei215 – 23117HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of peroxisomal membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 705705Inheritance of peroxisomes protein 2PRO_0000203314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi344 – 3441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis
Glycosylationi517 – 5171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi574 – 5741N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ03824.

Expressioni

Gene expression databases

GenevestigatoriQ03824.

Interactioni

Subunit structurei

Interacts with MYO2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MYO2P195243EBI-27354,EBI-11659
PEX19Q074183EBI-27354,EBI-292

Protein-protein interaction databases

BioGridi35340. 14 interactions.
DIPiDIP-1673N.
IntActiQ03824. 5 interactions.
MINTiMINT-385667.
STRINGi4932.YMR163C.

Structurei

3D structure databases

ProteinModelPortaliQ03824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the INP2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40466.
InParanoidiQ03824.
OMAiITHIASM.
OrthoDBiEOG7FJHBG.

Family and domain databases

InterProiIPR026235. INP2.
IPR026859. Myosin-bd.
[Graphical view]
PfamiPF12632. Vezatin. 1 hit.
[Graphical view]
PRINTSiPR02104. INPROXISOME2.

Sequencei

Sequence statusi: Complete.

Q03824-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTNSRPSAL QAPGLQIFSM LKSSEEDGFM SSSLTLDSDN IIGVTENNRQ
60 70 80 90 100
EFYSTWRKPS LLSSRSVLHE YSPTIVGSND CTFSPITVGK TTKFFNWDDI
110 120 130 140 150
ISRIFMQQPF GVTHQFFEEF RYSIITSHFL NDMNHYRLSL HLDQSIMNFH
160 170 180 190 200
KSSTLLKNVP PKSVPFMATK YGKLAVAEDK KLYFRQNFNY LSMIITSYRV
210 220 230 240 250
LTQLKKYCRK KNSPGLKRVV ILILVAVYLS IQQEYFRRHL ICYKTLLKVR
260 270 280 290 300
KVLESLQQVD VMIHKYHLRF KEIKNHSFIS RVSLISIADE HSSVIKELLV
310 320 330 340 350
FSSDALFYKL KSIIPDIVIF SDTSELSKYC ELYGIDVPNL YYNNTTTVKD
360 370 380 390 400
LDGKLYRLKL LKKFMLCCLL SLDMTGNENL SNVNMRNALN KIFPDYMARV
410 420 430 440 450
QLKKKYNPIG TFQNIVSLLR GLHSLLSTVL VSLNDHKQIL YAFPEETSTN
460 470 480 490 500
TGCERANVCS FSKNDKLFQA LNYLKMIENN LLAIDIRNGI TENDRNIIED
510 520 530 540 550
KLEELITFWK TSKICGNISR IQKVSPTNTI NHGFHLDILK GRKSPRSSSV
560 570 580 590 600
QGLSLERKVD FIDVAESVND SFENDTELEE YEDYDCQEEC SAGSRQNHRV
610 620 630 640 650
DFIGKDSCRK PDFKQLSDNE LRRKLDERIL KLAQENREGR ERLRTAKSFE
660 670 680 690 700
LLRKAQASMS VKFGFQKPLR DDAFLESRPL SKCKVSSEET IPFLYELKGL

LGNDS
Length:705
Mass (Da):81,467
Last modified:November 1, 1997 - v1
Checksum:iE4F2A4D205A98F66
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA. Translation: CAA89799.1.
BK006946 Genomic DNA. Translation: DAA10059.1.
PIRiS54521.
RefSeqiNP_013886.1. NM_001182667.1.

Genome annotation databases

EnsemblFungiiYMR163C; YMR163C; YMR163C.
GeneIDi855198.
KEGGisce:YMR163C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA. Translation: CAA89799.1.
BK006946 Genomic DNA. Translation: DAA10059.1.
PIRiS54521.
RefSeqiNP_013886.1. NM_001182667.1.

3D structure databases

ProteinModelPortaliQ03824.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35340. 14 interactions.
DIPiDIP-1673N.
IntActiQ03824. 5 interactions.
MINTiMINT-385667.
STRINGi4932.YMR163C.

Proteomic databases

PaxDbiQ03824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYMR163C; YMR163C; YMR163C.
GeneIDi855198.
KEGGisce:YMR163C.

Organism-specific databases

CYGDiYMR163c.
SGDiS000004773. INP2.

Phylogenomic databases

eggNOGiNOG40466.
InParanoidiQ03824.
OMAiITHIASM.
OrthoDBiEOG7FJHBG.

Enzyme and pathway databases

BioCyciYEAST:G3O-32853-MONOMER.

Miscellaneous databases

NextBioi978679.

Gene expression databases

GenevestigatoriQ03824.

Family and domain databases

InterProiIPR026235. INP2.
IPR026859. Myosin-bd.
[Graphical view]
PfamiPF12632. Vezatin. 1 hit.
[Graphical view]
PRINTSiPR02104. INPROXISOME2.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  5. "The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae."
    Fagarasanu A., Fagarasanu M., Eitzen G.A., Aitchison J.D., Rachubinski R.A.
    Dev. Cell 10:587-600(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MYO2.

Entry informationi

Entry nameiINP2_YEAST
AccessioniPrimary (citable) accession number: Q03824
Secondary accession number(s): D6VZY5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: January 7, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 736 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.