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Q037V3

- PUR9_LACC3

UniProt

Q037V3 - PUR9_LACC3

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Protein
Bifunctional purine biosynthesis protein PurH
Gene
purH, LSEI_1747
Organism
Lactobacillus casei (strain ATCC 334)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLCAS321967:GH4S-1746-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:LSEI_1747
OrganismiLactobacillus casei (strain ATCC 334)
Taxonomic identifieri321967 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000001651: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Bifunctional purine biosynthesis protein PurHUniRule annotation
PRO_1000018897Add
BLAST

Proteomic databases

PRIDEiQ037V3.

Interactioni

Protein-protein interaction databases

STRINGi321967.LSEI_1747.

Structurei

3D structure databases

ProteinModelPortaliQ037V3.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q037V3-1 [UniParc]FASTAAdd to Basket

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MKRALLSVSD KTGLVSFAKG LIDRGFELVS TGGTHRELAA AGIAVTSVEE    50
VTGFPEMLDG RVKTLHPKIH AGILARRDDP AHMEALADHD IQPVDLVCVN 100
LYPFAATIKR PDVTRAEAIE QIDIGGPSAL RAAAKNSDSV WAVVDPADYE 150
AVLTGLDQDD AHLRQKLAAK VFAITAAYDA QIVHYLDPEP FPEHFTPTYT 200
KRQDLRYGEN SHQQAAFYVE PDPNPTSLAA AKQLHGKELS YNNIKDADAA 250
LAMLREFSEP AVVAVKHMNP CGIGLGKTIE GAWDKAYAAD PMSIFGGIIA 300
LNRPVDLATA EKMHKLFLEI IMAPAFDDDA YAVLAKKKNV RLLTINTADT 350
PAELGTETTA IYGGLLIQAR DNQTETPADL TVVTTVKPTD EQLKALAFAQ 400
TVVKHVKSNA IVVAQADQTL GIGAGQMNRI GSVELALTQA QQNDNFAGAV 450
MASDAFFPMD DCVDYAAKHD IKAIIQPGGS IRDKDSIEKA NQYGIAMVTT 500
GVRHFRH 507
Length:507
Mass (Da):54,699
Last modified:November 14, 2006 - v1
Checksum:iC18A32B70EB3FD0F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ70519.1.
RefSeqiWP_011674595.1. NC_008526.1.
YP_806961.1. NC_008526.1.

Genome annotation databases

EnsemblBacteriaiABJ70519; ABJ70519; LSEI_1747.
GeneIDi4420227.
KEGGilca:LSEI_1747.
PATRICi22207223. VBILacCas62221_1726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000423 Genomic DNA. Translation: ABJ70519.1 .
RefSeqi WP_011674595.1. NC_008526.1.
YP_806961.1. NC_008526.1.

3D structure databases

ProteinModelPortali Q037V3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 321967.LSEI_1747.

Proteomic databases

PRIDEi Q037V3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABJ70519 ; ABJ70519 ; LSEI_1747 .
GeneIDi 4420227.
KEGGi lca:LSEI_1747.
PATRICi 22207223. VBILacCas62221_1726.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LCAS321967:GH4S-1746-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 334.

Entry informationi

Entry nameiPUR9_LACC3
AccessioniPrimary (citable) accession number: Q037V3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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