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Protein

37S ribosomal protein S8, mitochondrial

Gene

MRPS8

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.2 Publications

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • mitochondrial translation Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32848-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
37S ribosomal protein S8, mitochondrial
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS8m1 Publication
Gene namesi
Name:MRPS8
Ordered Locus Names:YMR158W
ORF Names:YM8520.07
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YMR158W.
SGDiS000004767. MRPS8.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: GO_Central
  • mitochondrial small ribosomal subunit Source: SGD

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001265991 – 15537S ribosomal protein S8, mitochondrialAdd BLAST155

Proteomic databases

MaxQBiQ03799.
PRIDEiQ03799.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature yeast 74S mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S small subunit contains a 15S ribosomal RNA (15S mt-rRNA) and 34 different proteins. The 54S large subunit contains a 21S rRNA (21S mt-rRNA) and 46 different proteins.2 Publications

Protein-protein interaction databases

BioGridi35333. 16 interactors.
DIPiDIP-6673N.
IntActiQ03799. 7 interactors.
MINTiMINT-671659.
STRINGi4932.YMR158W.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5MRCelectron microscopy3.25HH2-155[»]
5MREelectron microscopy3.75HH2-155[»]
5MRFelectron microscopy4.97HH2-155[»]
ProteinModelPortaliQ03799.
SMRiQ03799.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000204096.
InParanoidiQ03799.
OMAiWADLKYR.
OrthoDBiEOG092C55CV.

Family and domain databases

InterProiView protein in InterPro
IPR000630. Ribosomal_S8.
PANTHERiPTHR11758. PTHR11758. 1 hit.
PfamiView protein in Pfam
PF00410. Ribosomal_S8. 1 hit.
SUPFAMiSSF56047. SSF56047. 1 hit.

Sequencei

Sequence statusi: Complete.

Q03799-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVKLANTC AHLQNCSKVR VALTSIPYTK LQLQFAYNLY QQGFLSSLQK
60 70 80 90 100
GSTMGPDKDF VEVTPDNIST RRLWVGLKYR DNKPVLSSCK LISKPNSRIH
110 120 130 140 150
LPMEDMKKLC SGVTIRNIKP LQPGELILVR AHNNIMDINE AISKKLDGEV

LCRVK
Length:155
Mass (Da):17,471
Last modified:November 1, 1997 - v1
Checksum:i2C1C7F021627567A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49705 Genomic DNA. Translation: CAA89794.1.
AY558414 Genomic DNA. Translation: AAS56740.1.
BK006946 Genomic DNA. Translation: DAA10053.1.
PIRiS54516.
RefSeqiNP_013879.1. NM_001182661.1.

Genome annotation databases

EnsemblFungiiYMR158W; YMR158W; YMR158W.
GeneIDi855190.
KEGGisce:YMR158W.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT08_YEAST
AccessioniPrimary (citable) accession number: Q03799
Secondary accession number(s): D6VZX9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 5, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names