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Q03786 (GNTK_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable gluconokinase
EC=2.7.1.12
Alternative name(s):
Gluconate kinase
Gene names
Ordered Locus Names:YDR248C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length193 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + D-gluconate = ADP + 6-phospho-D-gluconate.

Pathway

Carbohydrate acid metabolism; D-gluconate degradation.

Subcellular location

Cytoplasm Ref.3.

Miscellaneous

Present with 504 molecules/cell in log phase SD medium.

Sequence similarities

Belongs to the gluconokinase GntK/GntV family.

Ontologies

Keywords
   Biological processGluconate utilization
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-gluconate catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from direct assay Ref.3. Source: SGD

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

gluconokinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 193193Probable gluconokinase
PRO_0000253810

Regions

Nucleotide binding18 – 258ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q03786 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 556C642E77B15759

FASTA19322,175
        10         20         30         40         50         60 
MTEKHKTMGK FKVIVLAGTA GTGKSTIAGE LIHEFKDIYP DLKFIEGDDL HPPANVEKMT 

        70         80         90        100        110        120 
RGIPLNDDDR WDWLKKVAVE STKAAASTKE HLSIVACSSL KKKYRDLIRH TCPESEFHFI 

       130        140        150        160        170        180 
FLYASKIEVL KRLKTRKGHF MKADMMESQF RDLELPDIND ETDCDIVPLD FKTFYQIEKD 

       190 
VIQVVKSKVL NIE

« Hide

References

« Hide 'large scale' references
[1]"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T. expand/collapse author list , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[3]"Global analysis of protein localization in budding yeast."
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K.
Nature 425:686-691(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
[4]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z49701 Genomic DNA. Translation: CAA89734.1.
BK006938 Genomic DNA. Translation: DAA12089.1.
PIRS54544.
RefSeqNP_010534.1. NM_001180556.1.

3D structure databases

HSSPHSSP built from PDB template 1KO1 based on UniProtKB P46859.
ProteinModelPortalQ03786.
SMRQ03786. Positions 13-186.
ModBaseSearch...

Protein-protein interaction databases

MINTMINT-2493287.
STRING4932.YDR248C.

Proteomic databases

PaxDbQ03786.
PeptideAtlasQ03786.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYDR248C; YDR248C; YDR248C.
GeneID851835.
KEGGsce:YDR248C.

Organism-specific databases

CYGDYDR248c.
SGDS000002656. YDR248C.

Phylogenomic databases

eggNOGCOG3265.
GeneTreeENSGT00390000003364.
HOGENOMHOG000032567.
KOK00851.
OMAFHSEANR.
OrthoDBEOG47WRXX.

Enzyme and pathway databases

UniPathwayUPA00792.

Gene expression databases

GenevestigatorQ03786.
GermOnlineYDR248C. Saccharomyces cerevisiae.

Family and domain databases

InterProIPR006001. Therm_gnt_kin.
[Graphical view]
TIGRFAMsTIGR01313. therm_gnt_kin. 1 hit.
ProtoNetSearch...

Other

NextBio969730.

Entry information

Entry nameGNTK_YEAST
AccessionPrimary (citable) accession number: Q03786
Secondary accession number(s): D6VSM9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome IV

Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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