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Q03784

- TRS23_YEAST

UniProt

Q03784 - TRS23_YEAST

Protein

Trafficking protein particle complex subunit 23

Gene

TRS23

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation.3 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. chromosome organization Source: SGD
    3. ER to Golgi vesicle-mediated transport Source: SGD
    4. positive regulation of Rab GTPase activity Source: GOC

    Keywords - Biological processi

    Autophagy, ER-Golgi transport, Transport

    Enzyme and pathway databases

    BioCyciYEAST:G3O-29819-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trafficking protein particle complex subunit 23
    Short name:
    TRAPP subunit 23
    Alternative name(s):
    Transport protein particle 23 kDa subunit
    Gene namesi
    Name:TRS23
    Ordered Locus Names:YDR246W
    ORF Names:YD8419.13
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IV

    Organism-specific databases

    CYGDiYDR246w.
    SGDiS000002654. TRS23.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: InterPro
    2. endoplasmic reticulum Source: UniProtKB-SubCell
    3. pre-autophagosomal structure Source: UniProtKB-SubCell
    4. TRAPPIII protein complex Source: SGD
    5. TRAPPII protein complex Source: SGD
    6. TRAPPI protein complex Source: SGD

    Keywords - Cellular componenti

    Endoplasmic reticulum, Golgi apparatus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 219219Trafficking protein particle complex subunit 23PRO_0000211571Add
    BLAST

    Proteomic databases

    MaxQBiQ03784.
    PaxDbiQ03784.

    Expressioni

    Gene expression databases

    GenevestigatoriQ03784.

    Interactioni

    Subunit structurei

    Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BET3P3614910EBI-19474,EBI-3567

    Protein-protein interaction databases

    BioGridi32297. 17 interactions.
    DIPiDIP-5813N.
    IntActiQ03784. 4 interactions.
    MINTiMINT-640620.
    STRINGi4932.YDR246W.

    Structurei

    Secondary structure

    1
    219
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi3 – 97
    Beta strandi17 – 204
    Helixi30 – 4011
    Helixi44 – 496
    Beta strandi121 – 1266
    Beta strandi128 – 1336
    Beta strandi139 – 1468
    Helixi170 – 19122
    Helixi205 – 21814

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CUEX-ray3.70A/G/M/S1-219[»]
    ProteinModelPortaliQ03784.
    SMRiQ03784. Positions 2-219.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ03784.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG5122.
    GeneTreeiENSGT00510000047061.
    HOGENOMiHOG000165619.
    OMAiYLILAST.
    OrthoDBiEOG7M98VC.

    Family and domain databases

    InterProiIPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view]
    PANTHERiPTHR23249. PTHR23249. 1 hit.
    PfamiPF04099. Sybindin. 3 hits.
    [Graphical view]
    SUPFAMiSSF64356. SSF64356. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q03784-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIETILVIN KSGGLIYQRN FTNDEQKLNS NEYLILASTL HGVFAIASQL    50
    TPKALQLTQQ TNIENTIPYI PYVGMSSNRS DTRNGGGNNN KHTNNEKLGS 100
    FKGDDFFKEP FTNWNKSGLR QLCTDQFTMF IYQTLTGLKF VAISSSVMPQ 150
    RQPTIATTDK PDRPKSTSNL AIQIADNFLR KVYCLYSDYV MKDPSYSMEM 200
    PIRSNLFDEK VKKMVENLQ 219
    Length:219
    Mass (Da):24,863
    Last modified:November 1, 1996 - v1
    Checksum:i8B32B1D5FE3846ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49701 Genomic DNA. Translation: CAA89732.1.
    BK006938 Genomic DNA. Translation: DAA12086.1.
    PIRiS54542.
    RefSeqiNP_010532.3. NM_001180554.3.

    Genome annotation databases

    EnsemblFungiiYDR246W; YDR246W; YDR246W.
    GeneIDi851833.
    KEGGisce:YDR246W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49701 Genomic DNA. Translation: CAA89732.1 .
    BK006938 Genomic DNA. Translation: DAA12086.1 .
    PIRi S54542.
    RefSeqi NP_010532.3. NM_001180554.3.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CUE X-ray 3.70 A/G/M/S 1-219 [» ]
    ProteinModelPortali Q03784.
    SMRi Q03784. Positions 2-219.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 32297. 17 interactions.
    DIPi DIP-5813N.
    IntActi Q03784. 4 interactions.
    MINTi MINT-640620.
    STRINGi 4932.YDR246W.

    Proteomic databases

    MaxQBi Q03784.
    PaxDbi Q03784.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YDR246W ; YDR246W ; YDR246W .
    GeneIDi 851833.
    KEGGi sce:YDR246W.

    Organism-specific databases

    CYGDi YDR246w.
    SGDi S000002654. TRS23.

    Phylogenomic databases

    eggNOGi COG5122.
    GeneTreei ENSGT00510000047061.
    HOGENOMi HOG000165619.
    OMAi YLILAST.
    OrthoDBi EOG7M98VC.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-29819-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q03784.
    NextBioi 969724.
    PROi Q03784.

    Gene expression databases

    Genevestigatori Q03784.

    Family and domain databases

    InterProi IPR011012. Longin-like_dom.
    IPR007233. Sybindin.
    [Graphical view ]
    PANTHERi PTHR23249. PTHR23249. 1 hit.
    Pfami PF04099. Sybindin. 3 hits.
    [Graphical view ]
    SUPFAMi SSF64356. SSF64356. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV."
      Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G., Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C., Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F., Delaveau T.
      , del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M., Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T., Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C., Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S., Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K., Mewes H.-W., Zollner A., Zaccaria P.
      Nature 387:75-78(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. "TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion."
      Sacher M., Jiang Y., Barrowman J., Scarpa A., Burston J., Zhang L., Schieltz D., Yates J.R. III, Abeliovich H., Ferro-Novick S.
      EMBO J. 17:2494-2503(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TRAPP II COMPLEX.
    4. "TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport."
      Sacher M., Barrowman J., Wang W., Horecka J., Zhang Y., Pypaert M., Ferro-Novick S.
      Mol. Cell 7:433-442(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION OF THE TRAPP II COMPLEX, IDENTIFICATION IN THE TRAPP II COMPLEX, SUBCELLULAR LOCATION.
    5. Cited for: IDENTIFICATION IN TRAPP COMPLEX.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    7. "Molecular architecture of the TRAPPII complex and implications for vesicle tethering."
      Yip C.K., Berscheminski J., Walz T.
      Nat. Struct. Mol. Biol. 17:1298-1304(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TRAP II COMPLEX, FUNCTION OF THE TRAP II COMPLEX.
    8. Cited for: IDENTIFICATION IN THE TRAPP III COMPLEX, SUBCELLULAR LOCATION, FUNCTION OF THE TRAPP III COMPLEX.

    Entry informationi

    Entry nameiTRS23_YEAST
    AccessioniPrimary (citable) accession number: Q03784
    Secondary accession number(s): D6VSM6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 16, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 3130 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IV
      Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names

    External Data

    Dasty 3